Association of volumetric bone mineral density with abdominal aortic calcification in African ancestry men

Kuipers, Allison L.; Zmuda, Joseph M.; Carr, J. Jeffrey; Terry, James G.; Patrick, Alan L.; Ge, Yaorong; Hightower, R. Caresse; Bunker, Clareann H.; Miljkovic, Iva

doi:10.1007/s00198-013-2486-3

Cited by 13 publications

(21 citation statements)

References 35 publications

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“…Additional segmentations of the psoas and paraspinous skeletal muscles were performed and corresponding volumes of fat and lean tissue calculated within a 30‐mm block of slices centered at L3‐4. Calcified atherosclerotic plaque was measured in the infrarenal abdominal aorta and common iliac arteries and reported as an Agatston score (Aquarius Workstation, TeraRecon, Foster City, CA, USA), as previously described …”

Section: Methodsmentioning

confidence: 99%

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Abdominal lean muscle is associated with lower mortality among kidney waitlist candidates

Locke

Carr

Nair

et al. 2017

Clinical Transplantation

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Morphometric assessments, such as muscle density and body fat distribution, have emerged as strong predictors of cardiovascular risk and post-operative morbidity and mortality. To date, no study has examined morphometric mortality risk prediction among kidney transplant (KT) candidates. KT candidates, waitlisted 2008–2009 were identified (n=96) and followed to the earliest of transplant, death, or administrative end of study. Morphometric measures, including abdominal adipose tissue, paraspinous and psoas muscle composition, and aortic calcification were measured from CTs. Risk of waitlist mortality was examined using Cox proportional hazards regression. On adjusted analyses, radiologic measures remained independently and significantly associated with lower waitlist mortality; the addition of radiologic measures significantly improved model predictive ability over models containing traditional risk factors alone (net reclassification index: 0.56, 95% CI: 0.31–0.75). Higher psoas muscle attenuation (indicative of leaner muscle) was associated with decreased risk of death (aHR: 0.93, 95% CI: 0.91–0.96, p< 0.001); and for each unit increase in lean paraspinous volume there was an associated 2% decreased risk for death (aHR: 0.98, 95%CI: 0.96–0.99, p=0.03). Radiologic measures of lean muscle mass, such as psoas muscle attenuation and paraspinous lean volume, may improve waitlist mortality risk prediction and candidate selection.

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Section: Methodsmentioning

confidence: 99%

“…The same methods employed for morphometric assessment of Calcified atherosclerotic plaque was measured in the infrarenal abdominal aorta and common iliac arteries and reported as an Agatston score (Aquarius Workstation, TeraRecon, Foster City, CA, USA), as previously described. 24,26,27…”

Section: Morphometric Measuresmentioning

confidence: 99%

Abdominal lean muscle is associated with lower mortality among kidney waitlist candidates

Locke

Carr

Nair

et al. 2017

Clinical Transplantation

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“…However, calcification begins in the larger arteries and then progresses to the smaller arteries [49,50], so our findings may largely reflect the earlier stage of vascular disease present in our population sample. Indeed, the prevalence of vascular calcification in these African ancestry men is lower than those seen in similarly aged US Caucasian and African American samples [51]. This is also the probable explanation for why BMI and waist circumference were the only measures associated with CAC in fully adjusted models.…”

Section: Discussionmentioning

confidence: 99%

Association of ectopic fat with abdominal aorto-illiac and coronary artery calcification in african ancestry men

et al. 2017

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Background and aims There is strong evidence that fat accumulating in non-adipose sites, “ectopic fat”, is associated with cardiovascular disease (CVD), including vascular calcification. Most previous studies of this association have assessed only a single ectopic fat depot. Therefore, our aim was to assess the association of total, regional, and ectopic fat with abdominal aortoilliac calcification (AAC) and coronary artery calcification (CAC) in 798 African ancestry men. Methods Participants (mean age 62) were from the Tobago Bone Health Study cohort. Adiposity was assessed via clinical examination, dual x-ray absorptiometry, and computed tomography (CT). Ectopic fat depots included: abdominal visceral adipose tissue (VAT), liver attenuation, and calf intermuscular adipose tissue (IMAT). Vascular calcification was assessed by CT and quantified as present versus absent. Associations were tested using multiple logistic regression adjusted for traditional cardiovascular risk factors. Models of ectopic fat were additionally adjusted for total body fat and standing height. Results All adiposity measures, except VAT, were associated with AAC. Lower liver attenuation or greater calf IMAT was associated with 1.2–1.3-fold increased odds of AAC (p < 0.03 for both), though calf IMAT was a stronger predictor than liver attenuation (p < 0.001) when entered in a single model. No ectopic fat measure was associated with CAC. Conclusions Greater adiposity in the skeletal muscle and liver, but not in the visceral compartment, was associated with increased odds of AAC in African ancestry men. These results highlight the potential importance of both quantity and location of adiposity accumulation throughout the body.

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“…The diagnosis of osteoporosis depends on area bone mineral density (BMD) measurements using dual energy X-ray absorptiometry (DXA) [ 2 ]. BMD has been inversely associated with subclinical and clinical cardiovascular disease (CVD), even after adjusting for potential confounding factors [ 3 ]. Previous studies have examined the relationship between trabecular volumetric BMD (vBMD) and aortic arterial calcification (AAC) or coronary artery calcification (CAC), with inconclusive results [ 3 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…BMD has been inversely associated with subclinical and clinical cardiovascular disease (CVD), even after adjusting for potential confounding factors [ 3 ]. Previous studies have examined the relationship between trabecular volumetric BMD (vBMD) and aortic arterial calcification (AAC) or coronary artery calcification (CAC), with inconclusive results [ 3 – 6 ]. Cortical, but not trabecular, vBMD was associated with significantly decreased odds of AAC prevalence independent of other traditional risk factors [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

TBS Predict Coronary Artery Calcification in Adults

Chuang¹,

Hsiao

Li³

et al. 2016

BioMed Research International

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Purpose. This study analyzes the association between the bony microarchitecture score (trabecular bone score, TBS) and coronary artery calcification (CAC) in adults undergoing health exams. Materials and Methods. We retrospectively collected subjects (N = 81) who underwent coronary computed tomography and bone mineral density studies simultaneously. CAC was categorized to three levels (Group 0, G0, no CAC, score = 0, N = 45; Group 1, G1, moderate CAC, score = 1–100, N = 17; Group 2, G2, high CAC, score ≧ 101, N = 19). Multinomial logistic regression was used to study the association between TBS and CAC levels. Results. CAC is present in 44.4% of the population. Mean TBS ± SD was 1.399 ± 0.090. Per 1 SD increase in TBS, the unadjusted odds ratio (2.393) of moderate CAC compared with no CAC was significantly increased (95% CI, 1.219–4.696, p = 0.011). However, there has been no association of TBS with high CAC (OR: 1.026, 95% CI: 0.586–1.797, p = 0.928). These relationships also existed when individually adjusted for age, sex, and multiple other covariates. Conclusions. Higher TBS was related to moderate CAC, but not high CAC; a possible explanation may be that bone microarchitecture remodeling becomes more active when early coronary artery calcification occurs. However, further researches are needed to clarify this pathophysiology.

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Association of volumetric bone mineral density with abdominal aortic calcification in African ancestry men

Cited by 13 publications

References 35 publications

Abdominal lean muscle is associated with lower mortality among kidney waitlist candidates

Abdominal lean muscle is associated with lower mortality among kidney waitlist candidates

Association of ectopic fat with abdominal aorto-illiac and coronary artery calcification in african ancestry men

TBS Predict Coronary Artery Calcification in Adults

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