A comparison of the predicted risk for cardiovascular disease between HIV-infected and uninfected persons in Korea

Kim, Sun Bean; Kim, Yong Chan; Kim, Min Hyung; Song, Je Eun; Oh, Dong Hyun; Ahn, Jin Young; Ku, Nam Su; Kim, Hye Won; Jeong, Su Jin; Han, Sang Hoon; Song, Young Goo; Choi, Jun Yong; Kim, June Myung

doi:10.3109/00365548.2013.813064

Cited by 9 publications

(8 citation statements)

References 35 publications

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“…According to a study conducted on 145 infected Koreans using carotid artery ultrasound, plaques were observed in 23.4% of infected individuals [ 20 ]. Although there have been no reports of an increase in myocardial infarction or stroke, the risk of cardiovascular disease may increase in the future, as it did in foreign countries, and so caution should be taken [ 21 ]. Bone diseases such as osteoporosis and kidney diseases are also long-term complications in HIV-infected persons in Korea.…”

Section: Clinical Characteristics Of Hiv Infection In Koreamentioning

confidence: 99%

History of Acquired Immune Deficiency Syndrome in Korea

Kim

Choi

et al. 2020

Infect Chemother

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The first human immunodeficiency virus (HIV) infection was reported in Korea in 1985. The number of HIV-infected persons domestically increased in the 1990s showing epidemic indigenousization. Since then, the number of new infections gradually increased every year, and recently more than 1,000 newly infected cases were reported per year. A total of 12,522 infected individuals have been reported up to 2015, of which 2,020 died. The male to female ratio was 15.4:1, and 34.2% of them were under 30 years old. The infection route was homosexual and bisexual contact in 60.1% of cases and heterosexual contact in 34.6% of cases. Candidiasis, Pneumocystis pneumonia, tuberculosis were common as a AIDS (acquired immune deficiency syndrome)-defining illness. But with the introduction of antiretroviral therapy in the late 1990s, non-AIDS defining illnesses such as metabolic complications, cardiovascular diseases, bone diseases, and neuropsychiatric disorders such as neurocognitive dysfunction, depression, and anxiety are emerging as new health problems. The management policy switched its focus from regulating and monitoring of HIV-infected persons to ensuring access to treatment and promotion of voluntary HIV testing in high-risk groups. Also as the age of the infected persons increases, a need for various supports such as social rehabilitation, life counseling, and welfare has emerged.

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Section: Clinical Characteristics Of Hiv Infection In Koreamentioning

confidence: 99%

History of Acquired Immune Deficiency Syndrome in Korea

Kim

Choi

et al. 2020

Infect Chemother

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“… 3 Controversies on the magnitude of CVD risk among individuals according to serostatus and specific drugs in ART regimens have been reported both in studies using biomarkers (such as carotid intima-media thickness (cIMT), pulse wave velocity (PWV), and flow-mediated dilatation), 4–6 as well as in studies using different CVD risk prediction algorithms/equations. Multiple studies have compared calculated risk between HIV-infected persons (both with and without ART) and controls and found conflicting results; some studies suggesting a similar risk, 7 , 8 others an increased risk due to chronic inflammation of the HIV-infection. 9 , 10 Some studies related this increased CVD risk to the adverse effect of ART due to dyslipidemia.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Predicted Cardiovascular Risk Profiles by Different CVD Risk-Scoring Algorithms between HIV-1-Infected and Uninfected Adults: A Cross-Sectional Study in Tanzania

Msoka¹,

Rogath²,

Guilder³

et al. 2021

HIV

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Purpose Cardiovascular disease (CVD) risk assessment is a suitable way to differentiate between high-risk individuals requiring intervention and risk modification, and those at low risk. However, concerns have been raised when adopting a CVD-risk prediction algorithm for HIV-infected patients in sub-Saharan Africa. Patients and Methods We compared cardiovascular risk profiles between HIV-infected (with and without antiretroviral therapy (ART)) and HIV-uninfected adults as predicted by the American College of Cardiology/American Heart Association (ASCVD) and the Framingham cardiovascular risk score (FRS) algorithms and assessed the concordance of the algorithms in predicting 10-year CVD risk separately in HIV-infected and uninfected groups in a hospital-based cross-sectional study in Tanzania. A cross-sectional hospital-based study including 40 HIV-infected ART-naive, 64 HIV-infected on ART, and 50 HIV-uninfected adults was conducted. Traditional cardiovascular risk factors were determined by standard investigations. The primary outcome was the absolute 10-year CVD risk score based on the two algorithms. Results Compared to HIV-uninfected, HIV-infected adults were classified at a higher 10-year CVD risk. ASCVD algorithms predicted a higher proportion of high-risk individuals compared to FRS in both HIV-infected and uninfected groups. The concordance between ASCVD and FRS-lipid algorithms was reasonable for both HIV-infected and uninfected groups though relatively higher in the HIV-uninfected group. Conclusion HIV-infected individuals have a higher 10-year cardiovascular risk compared to HIV-uninfected persons. The concordance between ASCVD and FRS-lipid algorithms is reasonable in both HIV-uninfected and infected persons in Tanzania. Development of an HIV-specific algorithm is needed to accurately predict CVD risk in this population at high-risk.

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“…However, these studies were limited by small sample sizes, and each study did not analyze metabolic parameters comprehensively (67891011). The purpose of the present study was to identify the prevalence of and evaluate the risk factors for metabolic complications in HIV-infected patients in Korea.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Complications among Korean Patients with HIV Infection: The Korea HIV/AIDS Cohort Study

Ahn

Kim

et al. 2017

J Korean Med Sci

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Currently, metabolic complications are the most common problem among human immunodeficiency virus (HIV)-infected patients, with a high incidence. However, there have been very few studies regarding metabolic abnormalities published in Asia, especially in Korea. This cross-sectional study was performed to investigate the prevalence of and risk factors for metabolic abnormalities in 1,096 HIV-infected patients of the Korea HIV/AIDS cohort study enrolled from 19 hospitals between 2006 and 2013. Data at entry to cohort were analyzed. As a result, the median age of the 1,096 enrolled subjects was 46 years, and most patients were men (92.8%). The metabolic profiles of the patients were as follows: median weight was 63.8 kg, median body mass index (BMI) was 22.2 kg/m2, and 16.4% of the patients had a BMI over 25 kg/m2. A total of 5.5% of the patients had abdominal obesity (waist/hip ratio ≥ 1 in men, ≥ 0.85 in women). Increased levels of fasting glucose, total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides were present in 10.4%, 6.0%, 5.5%, and 32.1% of the patients. Decreased high-density lipoprotein (HDL) cholesterol levels were observed in 44.2% of the patients. High systolic blood pressure was present in 14.3% of the patients. In multivariate analysis, high BMI and the use of protease inhibitors (PIs) were risk factors for dyslipidemia in HIV-infected patients. In conclusion, proper diagnosis and management should be offered for the prevalent metabolic complications of Korean HIV-infected patients. Further studies on risk factors for metabolic complications are needed.

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A comparison of the predicted risk for cardiovascular disease between HIV-infected and uninfected persons in Korea

Cited by 9 publications

References 35 publications

History of Acquired Immune Deficiency Syndrome in Korea

History of Acquired Immune Deficiency Syndrome in Korea

Comparison of Predicted Cardiovascular Risk Profiles by Different CVD Risk-Scoring Algorithms between HIV-1-Infected and Uninfected Adults: A Cross-Sectional Study in Tanzania

Metabolic Complications among Korean Patients with HIV Infection: The Korea HIV/AIDS Cohort Study

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