Clozapine pre-treatment has a protracted hypolocomotor effect on the induction and expression of amphetamine sensitization

Herrera, Andrea Susana; Casanova, José Patricio; Gatica, Rafael Ignacio; Escobar, Fabiola; Fuentealba, José Antonio

doi:10.1016/j.pnpbp.2013.07.023

Cited by 8 publications

(4 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The locomotor sensitisation protocol used in the present study was modified from Herrera et al . Horizontal locomotor activity was measured using an acrylic box (17 × 47 × 26 cm) in a behaviour test room.…”

Section: Methodsmentioning

confidence: 99%

Amphetamine treatment affects the extra‐hypothalamic vasopressinergic system in a sex‐ and nucleus‐dependent manner

Ahumada

Bahamondes

Cerda

et al. 2017

J Neuroendocrinology

View full text Add to dashboard Cite

The lateral septum (LS), a brain structure implicated in addictive behaviours, regulates the activation of dopaminergic neurones in the ventral tegmental area. Vasopressinergic projections from the extended amygdala to the LS, which are sexually dimorphic, could be responsible for the vulnerability to addiction in a sex-dependent manner. The present study aimed to investigate the modulatory effects of amphetamine (AMPH) on the expression of vasopressin (AVP) in the vasopressinergic extra-hypothalamic system in sensitised male and female rats. Adult male and female Sprague-Dawley rats underwent an AMPH-locomotor sensitisation protocol. Acute AMPH increased AVP mRNA expression in the medial amygdala (MeA), whereas AMPH-induced sensitisation increased AVP mRNA expression in the bed nucleus of the stria terminalis (BNST) only in females. Interestingly, the increase in AVP expression in BNST was higher in oestrus females compared to dioestrus females and acute AMPH resulted in a decrease in AVP levels in the LS, only in males. Thus, there are complex and region-specific interactions between AMPH and the extra-hypothalamic vasopressinergic system in the brain, underlying possible alterations in different behaviours caused by acute and chronic AMPH exposure.

show abstract

Section: Methodsmentioning

confidence: 99%

Amphetamine treatment affects the extra‐hypothalamic vasopressinergic system in a sex‐ and nucleus‐dependent manner

Ahumada

Bahamondes

Cerda

et al. 2017

J Neuroendocrinology

View full text Add to dashboard Cite

show abstract

“…Antipsychotic drugs primarily target dopamine receptor signaling at the dopamine D2 receptor. In animal models, antipsychotics that target D2 receptors induce dopamine neuron inactivation or block depolarization; treatment with amphetamine increases hyperactivity and other psychosis-relevant behaviors, and that treatment with the antipsychotic clozapine reverses these effects (Herrera et al, 2013; Valenti et al, 2011). Recently it has been suggested that hyperactivity of the DA signaling system may be related to reduced inhibitory neuron function in the hippocampus and ventral tegmentum, as selective reduction of parvalbumin interneurons in the hippocampus results in an increase in downstream dopamine neuron activity (Boley et al, 2014; Gilani et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Epigenetic mechanisms in schizophrenia

Shorter

Miller

2015

Progress in Biophysics and Molecular Biology

View full text Add to dashboard Cite

Epigenetic modifications, including DNA methylation, histone modifications, and non-coding RNAs, have been implicated in a number of complex diseases. Schizophrenia and other major psychiatric and neurodevelopmental disorders are associated with abnormalities in multiple epigenetic mechanisms, resulting in altered gene expression during development and adulthood. Polymorphisms and copy number variants in schizophrenia risk genes contribute to the high heritability of the disease, but environmental factors that lead to epigenetic modifications may either reduce or exacerbate the expression of molecular and behavioral phenotypes associated with schizophrenia and related disorders. In the present paper, we will review the current understanding of molecular dysregulation in schizophrenia, including disruption of the dopamine, NMDA, and GABA signaling pathways, and discuss the role of epigenetic factors underlying disease pathology.

show abstract

“…These observations are in line with the ability of chronic treatment with OLA to alleviate AMPH-induced hyperlocomotion in sensitized mice [ 33 ]. By contrast, repeated administration of CLZ does not attenuate MAP-induced hyperlocomotion [ 34 , 35 ] or reverse AMPH-induced hyperlocomotion [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Apocynin-Tandospirone Derivatives Suppress Methamphetamine-Induced Hyperlocomotion in Rats with Neonatal Exposure to Dizocilpine

Uehara

Kurachi

Kondo

et al. 2022

JPM

View full text Add to dashboard Cite

Accumulating evidence implicates oxidative stress as a potential pathophysiological mechanism of schizophrenia. Accordingly, we synthesized new chemicals using apocynin and tandospirone as lead compounds (A-2, A-3 and A-4). These novel compounds decreased reactive oxygen species (ROS) concentrations in vitro and reversed decreases in glutathione levels in the medial prefrontal cortex of rats transiently exposed to MK-801, an N-methyl-D-aspartate receptor antagonist, in the neonatal period. To determine whether A-2, A-3 and A-4 show behavioral effects associated with antipsychotic properties, the effects of these compounds on methamphetamine (MAP)-induced locomotor and vertical activity were examined in the model rats. A-2 and A-3, administered for 14 days around the puberty period, ameliorated MAP-induced hyperlocomotion in MK-801-treated rats in the post-puberty period, while A-4 suppressed MAP-induced vertical activity. These findings indicate that apocynin-tandospirone derivatives present anti-dopaminergic effects and may alleviate psychotic symptoms of schizophrenia.

show abstract

Clozapine pre-treatment has a protracted hypolocomotor effect on the induction and expression of amphetamine sensitization

Cited by 8 publications

References 41 publications

Amphetamine treatment affects the extra‐hypothalamic vasopressinergic system in a sex‐ and nucleus‐dependent manner

Amphetamine treatment affects the extra‐hypothalamic vasopressinergic system in a sex‐ and nucleus‐dependent manner

Epigenetic mechanisms in schizophrenia

Apocynin-Tandospirone Derivatives Suppress Methamphetamine-Induced Hyperlocomotion in Rats with Neonatal Exposure to Dizocilpine

Contact Info

Product

Resources

About