Intercoat (Oxiplex/AP Gel) for Preventing Intrauterine Adhesions After Operative Hysteroscopy for Suspected Retained Products of Conception: Double-Blind, Prospective, Randomized Pilot Study

Fertility outcome after treatment of retained products of conception: a systematic review

“…We found one randomised trial comparing anti-adhesion therapy with no treatment following surgical treatment [22]. There was no evidence of a statistically significant difference between both comparison groups for the outcome of IUAs at second-look hysteroscopy at 5 to 8 weeks (RR 0.32, 95% CI 0.04 to 2.80, P value = 0.30, one study, 41 women; Fig.…”

“…We found only one randomised study containing 41 participants on the use of an anti-adhesion barrier gel versus no treatment after hysteroscopic treatment of RPOC and one randomised study containing 86 participants on hysteroscopic morcellation versus loop resection for removal of RPOC [10,22]. Both studies had a high risk of bias on four out of seven items.…”

“…We included two parallel-design RCTs [10,22]. The first trial was performed in a tertiary medical care centre in Israel [22].…”

“…The first trial was performed in a tertiary medical care centre in Israel [22]. Fifty-two women underwent hysteroscopic surgery because of suspected RPOC.…”

“…However, for the trial performed by our group, we are considering follow-up of reproductive outcome for the patients as randomised [10]. Moreover, in the trial that did report on pregnancy, relevant information was lacking regarding the histologic criteria for RPOC, absolute numbers of pathologic confirmation of RPOC per group, the relation between histologic confirmation of RPOC and/or IUAs and/or fertility, as well as the number of women actually trying to reconceive after treatment of RPOC [22]. Our query related to these topics remained unanswered by the authors.…”