Antitumor and scavenging radicals activities of some polyphenols related to dehydroabietylamine derivatives

Liu, Chaoxiang; Zhao, Lin; Lu, Zuliang; Wang, Yimeng; Bao, Yongli

doi:10.1080/10286020.2013.808195

Cited by 5 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The synthetic routes of the title compounds are outlined in Scheme 1 [15]. Compound 3a was originated in Laboratory of our research group.…”

Section: Synthesismentioning

confidence: 99%

“…Our group has been interested in the synthesis of Schiff bases and acylamide of dehydroabietylamine derivatives. The cytotoxicities of dehydroabietylamine derivatives against PC-3, Hey-1B, L02 and HepG2 in vitro by the MTT assay were investigated [14,15]. As a result, these compounds also showed good selectivity towards these cells and DNA cleavage [16].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis, antitumor and DNA cleavage activities of a novel class of dehydroabietylamine derivatives

Liu

2020

Heliyon

View full text Add to dashboard Cite

Previous studies have reported higher biological activity of dehydrorosinamine derivatives. In order to further synthesize novel compounds with higher biological activity, a series of novel compounds containing benzo-az epine structures were synthesized from dehydroabietylamine in good yields in this study. The structures of synthesized compounds were identified by infra red (IR), 1 H-NMR, 13 C-NMR, and mass spectra (MS) analysis. The antitumor activities of the target compounds against L02 and HepG2 cells were studied. Furthermore, the dehydroabietylamine derivatives were studied on plasmid DNA cleavage activities. The results showed that the synthesized target compound exhibit antitumor and DNA cleavage activities against plasmid DNA (Escherichia coli). Our results further demonstrate the relationship between the chemical structure and biological function of the synthesized compounds.

show abstract

“…The synthetic routes of the title compounds are outlined in Scheme 1 [15]. Compound 3a was originated in Laboratory of our research group.…”

Section: Synthesismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis, antitumor and DNA cleavage activities of a novel class of dehydroabietylamine derivatives

Liu

2020

Heliyon

View full text Add to dashboard Cite

show abstract

“…To date, more than 8000 polyphenols have been separated and identified, the main class of which are flavonoids, stilbenes, lignans, curcuminoids, tannins, phenolic acids, and simple phenols [1]. Polyphenols contribute not only to color, aroma, and taste but also to many health‐promoting properties, such as antioxidant [2], antitumor [3], antiangiogenic [4], antimicrobial [5], and anti‐inflammatory [6] agents. Hence, considerable attentions have been recently focused on exploiting plants, fruits, or vegetables rich in polyphenols for the development of functional foods, nutraceuticals, or medicines.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Polyphenolic Profile of Plantago depressa using High‐Speed Countercurrent Chromatography Off‐line with High‐Performance Liquid Chromatography–Diode Array Detector–Quadrupole Time‐of‐flight Tandem Mass Spectrometry

Xu¹,

Tong²,

Fu³

et al. 2019

eFood

View full text Add to dashboard Cite

The whole plant of Plantago depressa is commonly used as traditional Chinese medicine and functional food ingredient. Total phenolic content and total flavonoid content evaluation indicated that its ethyl acetate and n-butanol fractions were rich in polyphenols. However, to date, the polyphenolic profile is limited because of the complex matrix. Here, polyphenols in ethyl acetate and n-butanol fractions of P. depressa were first separated and enriched by High-Speed Countercurrent Chromatography (HSCCC). Then, their structures were characterized or tentatively identified by High-Performance Liquid Chromatography (HPLC)-Diode Array Detector (DAD)-Quadrupole Time-of-Flight Tandem Mass Spectrometry (QTOF-MS/MS) (HSCCC × HPLC-DAD-QTOF-MS/MS). Because of the orthogonality of HSCCC and HPLC, 37 polyphenols were identified. Notably, 29 polyphenols were discovered from P. depressa for the first time. Finally, contents of two potential new compounds, 2-ethoxy plantamajoside isomers (17 and 29), were determined as 0.27 ± 0.03 and 0.04 ± 0.01 mg/g, respectively. Results indicated that P. depressa could be used as a promising source of polyphenols for health promotion, and the developed method (HSCCC × HPLC) was efficient to explore polyphenolic profile for complex natural products.

show abstract

Novel aromatic carboxamides from dehydroabietylamine as potential fungicides: Design, synthesis and antifungal evaluation

Yang

Liu

Sun

et al. 2022

Arabian Journal of Chemistry

View full text Add to dashboard Cite

Antitumor and scavenging radicals activities of some polyphenols related to dehydroabietylamine derivatives

Cited by 5 publications

References 15 publications

Synthesis, antitumor and DNA cleavage activities of a novel class of dehydroabietylamine derivatives

Synthesis, antitumor and DNA cleavage activities of a novel class of dehydroabietylamine derivatives

Comprehensive Polyphenolic Profile of Plantago depressa using High‐Speed Countercurrent Chromatography Off‐line with High‐Performance Liquid Chromatography–Diode Array Detector–Quadrupole Time‐of‐flight Tandem Mass Spectrometry

Novel aromatic carboxamides from dehydroabietylamine as potential fungicides: Design, synthesis and antifungal evaluation

Contact Info

Product

Resources

About