Probiotic Supplementation in Mothers of Very Low Birth Weight Infants

Benor, Shira; Marom, Ronella; Ben‐Tov, Amir; Domany, Keren Armoni; Zaidenberg-Israeli, Galit; Dollberg, Shaul

doi:10.1055/s-0033-1353490

Cited by 14 publications

(9 citation statements)

References 30 publications

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“…As shown in Figure 1, 35 studies met the inclusion criteria [21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55]. Fourteen additional papers were identified from the reference lists of included studies or by “snowballing” techniques [52,56,57,58,59,60,61,62,63,64,65,66,67,68].…”

Section: Resultsmentioning

confidence: 99%

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Probiotics and Time to Achieve Full Enteral Feeding in Human Milk-Fed and Formula-Fed Preterm Infants: Systematic Review and Meta-Analysis

et al. 2016

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Probiotics have been linked to a reduction in the incidence of necrotizing enterocolitis and late-onset sepsis in preterm infants. Recently, probiotics have also proved to reduce time to achieve full enteral feeding (FEF). However, the relationship between FEF achievement and type of feeding in infants treated with probiotics has not been explored yet. The aim of this systematic review and meta-analysis was to evaluate the effect of probiotics in reducing time to achieve FEF in preterm infants, according to type of feeding (exclusive human milk (HM) vs. formula). Randomized-controlled trials involving preterm infants receiving probiotics, and reporting on time to reach FEF were included in the systematic review. Trials reporting on outcome according to type of feeding (exclusive HM vs. formula) were included in the meta-analysis. Fixed-effect or random-effects models were used as appropriate. Results were expressed as mean difference (MD) with 95% confidence interval (CI). Twenty-five studies were included in the systematic review. In the five studies recruiting exclusively HM-fed preterm infants, those treated with probiotics reached FEF approximately 3 days before controls (MD −3.15 days (95% CI −5.25/−1.05), p = 0.003). None of the two studies reporting on exclusively formula-fed infants showed any difference between infants receiving probiotics and controls in terms of FEF achievement. The limited number of included studies did not allow testing for other subgroup differences between HM and formula-fed infants. However, if confirmed in further studies, the 3-days reduction in time to achieve FEF in exclusively HM-fed preterm infants might have significant implications for their clinical management.

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Section: Resultsmentioning

confidence: 99%

“…Twenty-four studies were excluded after examining the full-texts [28,29,31,32,33,35,42,43,44,45,46,47,51,53,54,55,57,58,59,62,63,65,69]. Twenty-five studies were then suitable for inclusion in the systematic review (Table 1) [21,22,23,24,25,26,27,30,34,36,37,38,39,40,41,48,49,50,56,60,61,64,66,68,70].…”

Section: Resultsmentioning

confidence: 99%

Probiotics and Time to Achieve Full Enteral Feeding in Human Milk-Fed and Formula-Fed Preterm Infants: Systematic Review and Meta-Analysis

et al. 2016

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“…110 An alternative would be to encourage the motivated parents to take a probiotic product themselves in hopes of transmitting the desired microbes to their infant. 111 …”

Section: Which Probiotic To Prevent Nec?mentioning

confidence: 99%

Impact of probiotics on necrotizing enterocolitis

Underwood

2017

Seminars in Perinatology

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A large number of randomized placebo-controlled clinical trials and cohort studies have demonstrated a decrease in the incidence of necrotizing enterocolitis with administration of probiotic microbes. These studies have prompted many neonatologists to adopt routine prophylactic administration of probiotics while others await more definitive studies and/or probiotic products with demonstrated purity and stable numbers of live organisms. Cross-contamination and inadequate sample size limit the value of further traditional placebo-controlled randomized controlled trials. Key areas for future research include mechanisms of protection, optimum probiotic species or strains (or combinations thereof) and duration of treatment, interactions between diet and the administered probiotic, and the influence of genetic polymorphisms in the mother and infant on probiotic response. Next generation probiotics selected based on bacterial genetics rather than ease of production and large cluster-randomized clinical trials hold great promise for NEC prevention.

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“…A number of studies support the benefits of specific probiotics and prebiotics in adults (Power et al, 2014), although the evidence is still scarce in infants and elders. Several studies indicate that prebiotics may be effective in decreasing the rate of overall infections in infants (Lohner et al, 2014) and that maternal probiotic supplementation may decrease the incidence of NEC in breastfed preterm babies (Benor et al, 2014). However, there is still a need for long-term follow-up of initiated probiotic studies to assess the impact of early life interventions for late efficacy (Videhult et al, 2014).…”

Section: Integrated Perspective and Future Trends Of The Human Intestmentioning

confidence: 99%

The human intestinal microbiome at extreme ages of life. Dietary intervention as a way to counteract alterations

et al. 2014

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The intestinal microbiome is defined as the assembly of genomes from microorganisms inhabiting the gut. This microbial ecosystem regulates important functions of the host and its correct composition and functionality is essential for a “healthy status.” Metagenomic studies have highlighted variations of the intestinal microbiota as a function of age and diet. Colonization of the infant gut starts at birth and is influenced by feeding habits (formula vs. breast-feeding), birth mode and antibiotic exposure. The intestinal microbiota of full-term vaginally delivered breast-fed infants is considered the gold-standard, representing the reference for studies of alterations in other pediatric populations. At 2–3 years of age, the intestinal microbiota reaches a composition similar to adults, remaining without noticeable variations until senescence, when microbial instability and changes reappear. Here we summarize the current knowledge on intestinal microbiota alterations at extreme stages of life and tools for designing differentiated nutritional strategies by the use of probiotics, prebiotics and specific nutrients in order to restore a balanced microbiota and to improve immune and nutritional status.

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Probiotic Supplementation in Mothers of Very Low Birth Weight Infants

Abstract: Postpartum maternal supplementation with probiotic bacteria may decrease the incidence of NEC in breastfed infants.

Cited by 14 publications

References 30 publications

Probiotics and Time to Achieve Full Enteral Feeding in Human Milk-Fed and Formula-Fed Preterm Infants: Systematic Review and Meta-Analysis

Probiotics and Time to Achieve Full Enteral Feeding in Human Milk-Fed and Formula-Fed Preterm Infants: Systematic Review and Meta-Analysis

Impact of probiotics on necrotizing enterocolitis

The human intestinal microbiome at extreme ages of life. Dietary intervention as a way to counteract alterations

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