Impact of a 2-year multimodal intervention for disruptive 6-year-olds on substance use in adolescence: randomised controlled trial

Castellanos‐Ryan, Natalie; Séguin, Jean R.; Vitaro, Frank; Parent, Sophie; Tremblay, Richard E.

doi:10.1192/bjp.bp.112.123182

Cited by 49 publications

(38 citation statements)

References 36 publications

(56 reference statements)

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“…Most importantly, perhaps, is that this elevated risk was manifested well in advance of the normative trends in alcohol use that are characteristic of late adolescence. Clearly these youth are the strongest candidates for targeted early interventions (van Lier et al, 2009, Castellanos-Ryan et al, 2013), and programs that aim to reduce delinquency may result in delayed drinking onset or reduced rates of risky drinking.…”

Section: Discussionmentioning

confidence: 99%

Adolescent Alcohol Use Before and After the High School Transition

Andreas¹,

Jackson

2015

Alcoholism Clin & Exp Res

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Background An important question is whether the high-school entry is a critical developmental event associated with escalation of alcohol use. The present study examined trajectories of adolescent alcohol use as a function of a normative developmental event, the high-school entry. In addition, given that at-risk youth may be particularly vulnerable to the stress associated with this transition, we examined how these alcohol use trajectories may be shaped by a measure of early behavioral risk, early adolescent delinquency. Methods Participants included 891 12-year olds from the prospective National Longitudinal Survey of Youth-1997 (NLSY97) for whom relevant longitudinal school data were available (51.2% boys; 61.4% White). Results Alcohol use after high-school entry increased at a significantly greater rate than did use during the middle-school years, even after accounting for students’ age at transition. In addition, early delinquency emerged as a risk factor such that differences in alcohol use existed prior to the transition. That is, children with early delinquency characteristics displayed more rapid progression in alcohol use, but this effect was evident only during middle school. Conclusions High-school entry appears to be a critical developmental event associated with increased social risk for greater alcohol use that goes beyond the simple maturational (i.e., ageing) factors. Youth with behavioral problems appear to be at greater risk in middle school, in contrast to lower risk youth for whom high school entry may be a more critical event, in part because high school is a less restrictive environment and/or because alcohol use becomes more normative at that time. Adolescent substance use may be described as a series of distinct developmental stages that closely correspond to school transitions, and suggest a critical period for targeted intervention that may differ as a function of pre-existing risk.

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Section: Discussionmentioning

confidence: 99%

Adolescent Alcohol Use Before and After the High School Transition

Andreas¹,

Jackson

2015

Alcoholism Clin & Exp Res

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“…Possible interventions and reducing externalizing behavior at 7-8 years of age may assist in reducing substance use behaviors during the peak of adolescence [10] or interventions targeted at reducing exposure in other adolescent drug users. We note that Figure 1 Longitudinal analysis of the Northern Finland Birth Cohort (NFBC) data for total drugs (Poisson path model).…”

Section: Discussionmentioning

confidence: 99%

“…In humans, PEMCS is associated with higher rates of externalizing behavior in pre-schoolers [4] and adolescents [5][6][7], as well as brain variations in young adults similar to those observed in attention deficit hyperactivity disorder [8]. Furthermore, developmentalcascade theories suggest etiological connections between externalizing behavior and substance use [9,10]. While this mediation pathway is clearly implicated, no studies have evaluated it formally.…”

Section: Introductionmentioning

confidence: 99%

Maternal cigarette smoking during pregnancy predicts drug use via externalizing behavior in two community‐based samples of adolescents

Lotfipour¹,

Ferguson

Leonard

et al. 2014

Addiction

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Maternal cigarette smoking during pregnancy predicts drug use via externalizing behavior in two community-based samples of adolescents ABSTRACTBackground and Aims Prenatal exposure to maternal cigarette smoking (PEMCS) is associated with a higher probability of substance use in adolescence. We explore if externalizing behavior mediates this relationship, while controlling for a number of potential covariates of this mediation process. Methods We used data obtained in two geographically distinct community samples of adolescents. The first (cross-sectional) sample consisted of 996 adolescents (12-18 years of age) recruited from the Saguenay Youth Study (SYS) in Canada (47% with PEMCS). The second (longitudinal) sample consisted of 1141 adolescents (49% with PEMCS) from the Northern Finland Birth Cohort (NFBC1986). In both samples, externalizing behavior and substance use were assessed during adolescence. In the NFBC1986 cohort, externalizing behavior was also assessed in childhood. Results In both populations, PEMCS is associated with a higher likelihood of adolescent drug experimentation. In the NFBC1986 cohort, exposed (versus non-exposed) adolescents experiment with an extra 1.27 [B = 0.24, 95% confidence intervals (CI) = 0.15, 0.33 P < 0.001] drugs. In the SYS cohort, a clear protective effect of not being exposed is shown: non-exposed (versus exposed) adolescents are 1.5 times [B = −0.42, 95% CI = −0.75, −0.09, P = 0.013] less likely to take drugs. These associations between PEMCS and drug experimentation remain in the multivariate and mediational analyses. Conclusions Prenatal exposure to maternal cigarette smoking appears to be associated with a higher probability of experimenting with drugs during adolescence, both directly and indirectly via externalizing behavior and the number of peers reported as using drugs.

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“…The follow-up of the boys during adolescence indicated that the preventive intervention between 7 and 9 years of age had reduced the number of aggressive kindergarten boys who were placed out of an age-appropriate regular classroom (Tremblay, Pagani-Kurtz, Mâsse, Vitaro, & Pihl, 1995), the frequency of physical aggressions and thefts between 11 and 17 years of age (Lacourse et al, 2002), and the frequency of substance use between 14 and 17 years (Castellanos-Ryan, Séguin, Vitaro, Parent, & Tremblay, 2013;Tremblay, Mâsse, Pagani, & Vitaro, 1996). When the boys turned 24 years of age, we collected data on high-school completion and crime data from courts.…”

Section: Helping Boys With Chronic Physical Aggression During the Elementioning

confidence: 99%

Sex differences in the development of physical aggression: An intergenerational perspective and implications for preventive interventions

Tremblay

Côté

2019

Infant Mental Health Journal

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This article reviews the state of knowledge on the development of chronic physical aggression (CPA), with the aim of identifying the most effective prevention strategies. We specifically focus on the early development of physical aggression, on sex differences in the use of physical aggression, and on the transmission of behavior problems from one generation to the other. The body of research on the development of CPA from the past three decades that we review shows increasing evidence that its prevention requires a long‐term biopsychosocial developmental approach which also must include an intergenerational perspective. Recent genetic and epigenetic research has indicated that there are both important genetic and environmental effects on gene expression which start at conception. We conclude that one of the most effective strategies to break the intergenerational transmission of CPA involves giving long‐term support to pregnant women with a history of behavior problems, their spouse, and their offspring.

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Impact of a 2-year multimodal intervention for disruptive 6-year-olds on substance use in adolescence: randomised controlled trial

Abstract: Adolescent substance use may be indirectly prevented by selectively targeting childhood risk factors that disrupt the developmental cascade of adolescent risk factors for substance use.

Cited by 49 publications

References 36 publications

Adolescent Alcohol Use Before and After the High School Transition

Adolescent Alcohol Use Before and After the High School Transition

Maternal cigarette smoking during pregnancy predicts drug use via externalizing behavior in two community‐based samples of adolescents

Sex differences in the development of physical aggression: An intergenerational perspective and implications for preventive interventions

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