Determinants of thoughts of death or suicide in depressed older persons

Bogers, Ista C. H. M.; Zuidersma, Marij; Boshuisen, Marjolein; Comijs, Hannie C.; Voshaar, Richard C. Oude

doi:10.1017/s1041610213001166

Cited by 18 publications

(17 citation statements)

References 32 publications

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“…Between 11% and 19% of community dwelling older persons reports thoughts of death or death wishes (Rurup et al, 2011a(Rurup et al, , 2011bFässberg et al, 2013), which is only slightly lower compared with prevalence rates among depressed older persons (Szanto et al, 2003;Bogers et al, 2013). Thoughts of death are less closely associated with severity of psychopathology and feelings of self-hatred (Szanto et al, 1996;Bogers et al, 2013). Thoughts of death and thoughts of suicide may thus differentially impact on the course of depressive disorders in older persons.…”

Section: Introductionmentioning

confidence: 85%

“…Depressed older patients with suicidal ideation suffer from more severe depressive symptoms compared with depressed patients without suicidal ideation (Bogers et al, 2013). Whether suicidal ideation affects the course of late-life depression remains a matter of debate (Szanto et al, 2001(Szanto et al, , 2007.…”

Section: Introductionmentioning

confidence: 99%

“…Between 11% and 19% of community dwelling older persons reports thoughts of death or death wishes (Rurup et al, 2011a(Rurup et al, , 2011bFässberg et al, 2013), which is only slightly lower compared with prevalence rates among depressed older persons (Szanto et al, 2003;Bogers et al, 2013). Between 11% and 19% of community dwelling older persons reports thoughts of death or death wishes (Rurup et al, 2011a(Rurup et al, , 2011bFässberg et al, 2013), which is only slightly lower compared with prevalence rates among depressed older persons (Szanto et al, 2003;Bogers et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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The influence of thoughts of death and suicidal ideation on the course of depression in older depressed patients

Bogers

Zuidersma

Boshuisen

et al. 2016

Int J Geriatr Psychiatry

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Patients with thoughts of death or with thoughts of suicide were more severely depressed at baseline and follow-up, with the highest risk of being depressed at follow-up for patients with thoughts of suicide. These associations could be explained by baseline depression severity. The results suggest that thoughts of death and thoughts of suicide are important risk markers in predicting the course of depression. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

“…Between 11% and 19% of community dwelling older persons reports thoughts of death or death wishes (Rurup et al, 2011a(Rurup et al, , 2011bFässberg et al, 2013), which is only slightly lower compared with prevalence rates among depressed older persons (Szanto et al, 2003;Bogers et al, 2013). Between 11% and 19% of community dwelling older persons reports thoughts of death or death wishes (Rurup et al, 2011a(Rurup et al, , 2011bFässberg et al, 2013), which is only slightly lower compared with prevalence rates among depressed older persons (Szanto et al, 2003;Bogers et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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The influence of thoughts of death and suicidal ideation on the course of depression in older depressed patients

Bogers

Zuidersma

Boshuisen

et al. 2016

Int J Geriatr Psychiatry

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“…These findings agree with Zisook et al (2009) who found that depression severity, concurrent substance abuse and melancholia were associated with TESI in a report from the STAR*D trial. Likewise, other studies have pointed at depression severity, medical, and psychiatric comorbidity (including anxiety) as predictors of suicidal ideation independent of treatment (Alexopoulos et al ., 2009; Bogers et al ., 2013; Shah et al ., 2000; Lenze et al ., 2000; Seo et al ., 2011)…”

Section: Discussionmentioning

confidence: 99%

Treatment Emergent Suicidal Ideation in depressed older adults

Cristancho

O'Connor

Lenze

et al. 2016

Int J Geriat Psychiatry

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Background Treatment-Emergent Suicidal Ideation (TESI) in older adults is poorly understood. We characterized TESI in older depressed adults during treatment with venlafaxine and explored whether TESI is related to antidepressant exposure versus dimensions of the psychiatric illness. We examined the relationship among medication exposure, onset of TESI, and clinical characteristics. Methods We analyzed data on 233 clinical trial participants with major depression and no baseline suicidal ideation who were treated for up to 12 weeks with venlafaxine XR (target dose: 150–300 mg/day). Suicidal ideation was assessed weekly with the Scale for Suicide Ideation. A Kaplan-Meier curve displayed the time course of TESI. Differences in baseline demographic and clinical variables between the TESI and Non-TESI groups were assessed with analyses of covariance or logistic regression. A final multivariate logistic regression model indicated baseline predictors of TESI. Depression treatment outcomes in subjects developing TESI versus those who did not were examined with a mixed effects model. Results TESI occurred in 10% of participants, typically with onset within 4 weeks of the start of treatment. Anxiety, and depression severity at baseline were predictors of TESI. Most TESI was mild and transient, with 6/233 participants having TESI considered clinically meaningful. TESI was not associated with venlafaxine blood levels or side effects. Conclusions In older depressed adults, TESI is relatively uncommon and it is likely related to the underlying illness rather than to a medication adverse effect. This suggests that TESI requires continuing rather than discontinuing antidepressant treatment.

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“…In depressed older adults, suicidal ideation is associated with higher severity of depression, previous suicide attempts, greater medical and psychiatric comorbidity (i.e. panic disorder and alcohol abuse), loneliness, and lower subjective social support [19–21]. In a study of Korean elders, depression mediated the relationship of social support and low income with suicidal ideation [22].…”

Section: Recent Findings On Major Depression Schizophrenia and Suicmentioning

confidence: 99%

Suicide in Older Adults: The Role of Emotions and Cognition

Kiosses

Szántó

Alexopoulos

2014

Curr Psychiatry Rep

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Suicide in older adults is a significant clinical concern. In this review of recent findings, we concentrate on the role of emotions and cognition in suicide risk and behavior in older adults. We discuss the epidemiology of suicide in older adults, integrate recent findings on non-psychotic major depression, schizophrenia and suicidal ideation, explore the relationship of emotion regulation with suicide, present recent advances on suicide in demented patients, and describe the latest developments on cognition and decision processes in suicide.

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Determinants of thoughts of death or suicide in depressed older persons

Abstract: In depressed older persons thoughts of death and suicide differ in relevant demographic, social, and clinical characteristics, suggesting that the risks and consequences of the two conditions differ.

Cited by 18 publications

References 32 publications

The influence of thoughts of death and suicidal ideation on the course of depression in older depressed patients

The influence of thoughts of death and suicidal ideation on the course of depression in older depressed patients

Treatment Emergent Suicidal Ideation in depressed older adults

Suicide in Older Adults: The Role of Emotions and Cognition

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