2013
DOI: 10.1172/jci68782
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Type 2 alveolar cells are stem cells in adult lung

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Cited by 1,452 publications
(1,812 citation statements)
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References 46 publications
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“…It appears that A549 cells may actually possess natural capabilities of type II cells that are activated by matrix cues. This is in corroboration with other reports showing that type II epithelial cells serve as progenitors and are able to convert to type I respiratory cells and repair damaged alveolar epithelium in the case of injury or during lung development (Barkauskas et al 2013). Similarly, the ability of A549 cells to spontaneously differentiate into type I cells and obtain their differential properties, like expression of TTF-1 and enlarged flat phenotype, over the time has been reported previously (Khubchandani and Snyder 2001;Swain et al 2010;Zu et al 2012) and further supports our results.…”
Section: Discussionsupporting
confidence: 93%
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“…It appears that A549 cells may actually possess natural capabilities of type II cells that are activated by matrix cues. This is in corroboration with other reports showing that type II epithelial cells serve as progenitors and are able to convert to type I respiratory cells and repair damaged alveolar epithelium in the case of injury or during lung development (Barkauskas et al 2013). Similarly, the ability of A549 cells to spontaneously differentiate into type I cells and obtain their differential properties, like expression of TTF-1 and enlarged flat phenotype, over the time has been reported previously (Khubchandani and Snyder 2001;Swain et al 2010;Zu et al 2012) and further supports our results.…”
Section: Discussionsupporting
confidence: 93%
“…The idea of our study is to design native and relevant 3D lung model from post-mortem decellularized (DCL) lung tissue and evaluate growth and survival of human lung epithelial cells (line A549) in various COPD-related experimental designs. A549 in our model represent type II epithelial cells that are known as self renewing in culture and able to differentiate into alveolar-like structures ''alveospheres'' containing type II and type I epithelial cells (Barkauskas et al 2013).…”
Section: Introductionmentioning
confidence: 99%
“…Thus, embryonic Tbx4 enhancer activity and adult Col1 transcription appear to match in spatially separated mesenchymal populations with the features of pericytes and resident fibroblasts. 8,10,21 The pattern of PDGFR-a expression also matches this connection. A large population of PDGFR-a þ , a-SMA þ myofibroblasts position themselves adjacent to PDGF-A þ epithelial cells and play a crucial role in generating the septae between alveoli before embryonic day 18.5.…”
Section: Lung Pericytes and Resident Fibroblastssupporting
confidence: 57%
“…Moreover, in adult lung PDGFR-a, lineage marking included lipid-bearing lipofibroblasts able to support the growth and differentiation of type II airway epithelial cells. 21,40 Thus, both Tbx4 À and PDGFR-a tracing correspond with the identification of PDGFR-a þ Col1 þ interstitial fibroblasts and pericytes in adult lung. 10 …”
Section: Lung Pericytes and Resident Fibroblastsmentioning
confidence: 57%
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