Effect of ultrasound irradiation on the production of nHAp/MWCNT nanocomposites

Lobo, Anderson Oliveira; Zanin, Hudson; Siqueira, Idália A. W. B.; Leite, Nelly C. S.; Marciano, Fernanda Roberta; Corat, Evaldo José

doi:10.1016/j.msec.2013.06.032

Cited by 41 publications

(40 citation statements)

References 44 publications

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“…During the biomimetic coating period, the pH of each solution where the scaffolds were immersed was verified (WTW, model pH3210) every 48 h, when the SBF solution was exchanged. This analysis was performed to control the saturation of calcium phosphates …”

Section: Methodsmentioning

confidence: 99%

Surface modification using the biomimetic method in alumina‐zirconia porous ceramics obtained by the replica method

et al. 2018

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The modification of biomaterials approved by the Food and Drug Administration could be an alternative to reduce the period of use in humans. Porous bioceramics are widely used as support structures for bone formation and repair. This composite has essential characteristics for an implant, including good mechanical properties, high chemical stability, biocompatibility and adequate aesthetic appearance. Here, three-dimensional porous scaffolds of Al O containing 5% by volume of ZrO were produced by the replica method. These scaffolds had their surfaces chemically treated with phosphoric acid and were coated with calcium phosphate using the biomimetic method simulated body fluid (SBF, 5×) for 14 days. The scaffolds, before and after biomimetic coating, were characterized mechanically, morphologically and structurally by axial compression tests, scanning electron microscopy, microtomography, apparent porosity, X-ray diffractometry, near-infrared spectroscopy, inductively coupled plasma optical emission spectroscopy, energy dispersive X-ray spectroscopy and reactivity. The in vitro cell viability and formation of mineralization nodules were used to identify the potential for bone regeneration. The produced scaffols after immersion in SBF were able to induce the nodules formation. These characteristics are advantaged by the formation of different phases of calcium phosphates on the material surface in a reduced incubation period. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2615-2624, 2018.

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Section: Methodsmentioning

confidence: 99%

Surface modification using the biomimetic method in alumina‐zirconia porous ceramics obtained by the replica method

et al. 2018

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“…[12][13][14][15][16] Combining MWCNTs and GO with HAp in its many forms (such as nano) represents an alternative to improve the chemical, physical, and biological characteristics of polymeric nanocomposites, as well as to generate materials that can mimic bone tissues. 11,[17][18][19] For example, Lahiri et al 20 demonstrated that MWCNTs were responsible for increasing the adhesion strength, and spreading and attachment of osteoblasts in HAp/MWCNT nanocomposites. Balani et al 21 reported on the improvement of the fracture toughness and crystallinity of the coating of HAp/MWCNT nanocomposites prepared by plasma spraying.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, our group developed a novel routine to produce large-scale nHAp/MWCNT-GO nanocomposites using a wet-chemical method assisted by ultrasound irradiation. 19 Therefore, herein, we present for the first time a systematic evaluation of the production and characterization of nHAp/ MWCNT-GO nanocomposites. We evaluated the physical, chemical, and biological properties of nHAp/MWCNT-GO nanocomposites.…”

Section: Introductionmentioning

confidence: 99%

“…45,46 However, in the present investigation, we could not achieve the total removal of iron from the interior of the MWCNTs. Table 2 shows the crystallite size, evaluated by using the Sherrer equation 19 for all samples after being soaked in SBF (1.5x) for 14 and 21 days. We observed an increase in MWCNT-GO crystallite size with an increase in the time of soaking in SBF.…”

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Graphene oxide/multi-walled carbon nanotubes as nanofeatured scaffolds for the assisted deposition of nanohydroxyapatite: characterization and biological evaluation

Rodrigues¹,

Leite²,

Cavalcanti³

et al. 2016

IJN

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Nanohydroxyapatite (nHAp) is an emergent bioceramic that shows similar chemical and crystallographic properties as the mineral phase present in bone. However, nHAp presents low fracture toughness and tensile strength, limiting its application in bone tissue engineering. Conversely, multi-walled carbon nanotubes (MWCNTs) have been widely used for composite applications due to their excellent mechanical and physicochemical properties, although their hydrophobicity usually impairs some applications. To improve MWCNT wettability, oxygen plasma etching has been applied to promote MWCNT exfoliation and oxidation and to produce graphene oxide (GO) at the end of the tips. Here, we prepared a series of nHAp/MWCNT-GO nanocomposites aimed at producing materials that combine similar bone characteristics (nHAp) with high mechanical strength (MWCNT-GO). After MWCNT production and functionalization to produce MWCNT-GO, ultrasonic irradiation was employed to precipitate nHAp onto the MWCNT-GO scaffolds (at 1–3 wt%). We employed various techniques to characterize the nanocomposites, including transmission electron microscopy (TEM), Raman spectroscopy, thermogravimetry, and gas adsorption (the Brunauer–Emmett–Teller method). We used simulated body fluid to evaluate their bioactivity and human osteoblasts (bone-forming cells) to evaluate cytocompatibility. We also investigated their bactericidal effect against Staphylococcus aureus and Escherichia coli . TEM analysis revealed homogeneous distributions of nHAp crystal grains along the MWCNT-GO surfaces. All nanocomposites were proved to be bioactive, since carbonated nHAp was found after 21 days in simulated body fluid. All nanocomposites showed potential for biomedical applications with no cytotoxicity toward osteoblasts and impressively demonstrated a bactericidal effect without the use of antibiotics. All of the aforementioned properties make these materials very attractive for bone tissue engineering applications, either as a matrix or as a reinforcement material for numerous polymeric nanocomposites.

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“…Many studies have been reported for the use of MWNT as an additive in various types of ceramics. Nanosize HA composites with MWNT were studied with an aqueous precipitation process to examine the possible application as a scaffold for bone regeneration [9]. Agarwal group evaluated the effect of CNT addition to plasma-sprayed HA coating on its tribological behavior and biocompatibility of the coating and the cytotoxicity of CNT-containing HA wear debris [10].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Multiwalled Carbon Nanotube-Reinforced Hydroxyapatite Composites Consolidated by Spark Plasma Sintering

Kim

Han

Lee

et al. 2014

BioMed Research International

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Pure HA and 1, 3, 5, and 10 vol% multiwalled carbon nanotube- (MWNT-) reinforced hydroxyapatite (HA) were consolidated using a spark plasma sintering (SPS) technique. The relative density of pure HA increased with increasing sintering temperature, but that of the MWNT/HA composite reached almost full density at 900°C, and then decreased with further increases in sintering temperature. The relative density of the MWNT/HA composites increased with increasing MWNT content due to the excellent thermal conductivity of MWNTs. The grain size of MWNT/HA composites decreased with increasing MWNT content and increased with increasing sintering temperature. Pull-out toughening of the MWNTs of the MWNT/HA composites was observed in the fractured surface, which can be used to predict the improvement of the mechanical properties. On the other hand, the existence of undispersed or agglomerate MWNTs in the MWNT/HA composites accompanied large pores. The formation of large pores increased with increasing sintering temperature and MWNT content. The addition of MWNT in HA increased the hardness and fracture toughness by approximately 3~4 times, despite the presence of large pores produced by un-dispersed MWNTs. This provides strong evidence as to why the MWNTs are good candidates as reinforcements for strengthening the ceramic matrix. The MWNT/HA composites did not decompose during SPS sintering. The MWNT-reinforced HA composites were non-toxic and showed a good cell affinity and morphology in vitro for 1 day.

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Effect of ultrasound irradiation on the production of nHAp/MWCNT nanocomposites

Cited by 41 publications

References 44 publications

Surface modification using the biomimetic method in alumina‐zirconia porous ceramics obtained by the replica method

Surface modification using the biomimetic method in alumina‐zirconia porous ceramics obtained by the replica method

Graphene oxide/multi-walled carbon nanotubes as nanofeatured scaffolds for the assisted deposition of nanohydroxyapatite: characterization and biological evaluation

Characterization of Multiwalled Carbon Nanotube-Reinforced Hydroxyapatite Composites Consolidated by Spark Plasma Sintering

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