Influence of gallic acid on oxidative stress-linked streptozotocin-induced pancreatic dysfunction in diabetic rats

Kade, Ige Joseph; Ogunbolude, Yetunde; Kamdem, Jean Paul; Rocha, João Batista Teixeira da

doi:10.1515/jbcpp-2012-0062

Cited by 19 publications

(12 citation statements)

References 51 publications

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“…In the present study, the amount of LPO product, MDA was higher in diabetic rats' pancreas as compared no non-diabetic rats indicating of high levels of oxidative stress due to intensified free-radical formation 53 . Our findings were in agreement with Kade et al 54 who reported that high amount of LPO product was observed in diabetic rats' pancreas. C. borivilianum root extract administration to diabetic rats lowered the LPO product, indicating that this plant extract could prevent elevation of oxidative stress of the pancreas in diabetes.…”

Section: Discussionsupporting

confidence: 94%

Chlorophytum borivilianum Root Extract Maintains near Normal Blood Glucose, Insulin and Lipid Profile Levels and Prevents Oxidative Stress in the Pancreas of Streptozotocin-Induced Adult Male Diabetic Rats

Giribabu¹,

Kilari²,

Rekha³

et al. 2014

Int. J. Med. Sci.

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The effect of C. borivilianum root on blood glucose, glycated hemoglobin (HbAIc), insulin and lipid profile levels in diabetes mellitus are not fully understood. This study therefore investigated the effect of C. borivilianum root on the above parameters and oxidative stress of the pancreas in diabetes. Methods: C. borivilianum root aqueous extract (250 and 500 mg/kg/day) was administered to streptozotocin (STZ)-induced male diabetic rats for 28 days. Body weight, blood glucose, HbA1c, insulin, lipid profile levels and glucose homeostasis indices were determined. Histopathological changes and oxidative stress parameters i.e. lipid peroxidation (LPO) and antioxidant enzymes activity levels of the pancreas were investigated. Results: C. borivilianum root extract treatment to diabetic rats maintained near normal body weight, blood glucose, HbA1c, lipid profile and insulin levels with higher HOMA-β cell functioning index, number of Islets/pancreas, number of β-cells/Islets however with lower HOMA-insulin resistance (IR) index as compared to non-treated diabetic rats. Negative correlations between serum insulin and blood glucose, HbA1c, triglyceride (TG) and total cholesterol (TC) levels were observed. C. borivilianum root extract administration prevented the increase in lipid peroxidation and the decrease in activity levels of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) with mild histopathological changes in the pancreas of diabetic rats. Conclusions: C. borivilianum root maintains near normal levels of these metabolites and prevented oxidative stress-induced damage to the pancreas in diabetes.

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Section: Discussionsupporting

confidence: 94%

Chlorophytum borivilianum Root Extract Maintains near Normal Blood Glucose, Insulin and Lipid Profile Levels and Prevents Oxidative Stress in the Pancreas of Streptozotocin-Induced Adult Male Diabetic Rats

Giribabu¹,

Kilari²,

Rekha³

et al. 2014

Int. J. Med. Sci.

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“…A lot of scientific research studies provide potential evidence about health benefits of polyphenol to humans. Particularly, gallic acid is reported to produce antioxidant effect by elevating the decreased levels of hepatic catalase enzyme and vitamin C in diabetic rats, and it also defend against damage produced by oxidative stress in hyperglycemic state [36,37]. Caffeic acid potentially reduces weight loss, plasma glucose, and triglycerides levels and increases insulin concentration in diabetic rats [38].…”

Section: Estimation Of Intracellular Ros and Measurement Ofmentioning

confidence: 99%

Effect of Caesalpinia bonduc Polyphenol Extract on Alloxan-Induced Diabetic Rats in Attenuating Hyperglycemia by Upregulating Insulin Secretion and Inhibiting JNK Signaling Pathway

Iftikhar

Aslam

Iftikhar

et al. 2020

Oxidative Medicine and Cellular Longevity

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Caesalpinia bonduc has been used in herbal medicines for the treatment of a wide range of diseases from decades. The present study has explored the remedial potential and underlying mechanism of polyphenol extract of Caesalpinia bonduc in alloxanized diabetic rats. HPLC/MS analysis confirmed the presence of phenolics in considerable concentrations in Caesalpinia bonduc extract. Administration of different doses (250 and 500 mg/kg) of CPP extract to hyperglycemic rats for 8 weeks restored blood and serum glucose, insulin, glycosylated hemoglobin, leptin, amylin, and carbohydrate metabolizing enzymes level towards normal compared to alloxanized diabetic group. The effect of CPP extract on various genes such as Pdx-1, Ins-1, ngn-3, GLUT-4, and IRS-1 in insulin signaling pathway and Traf-4, Traf-6, and Mapk-8 in MAPK downstream JNK cascade was examined through qRT-PCR to access the core molecular mechanism involved in CPP-induced recovery of diabetes. Results have revealed that CPP extract reduced oxidative stress in pancreatic β cells by restoring free radical scavenging potential, reducing the mRNA expression of Mapk-8, Traf-4, and Traf-6, and increasing the Pdx-1, Ins-1, ngn-3, GLUT-4, and IRS-1 expression ensuing regeneration of β cells and subsequent insulin release from pancreas. The results obtained in this study recommend that CPP extract may be a promising therapeutic restorative agent in the treatment of diabetes mellitus.

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“…Intra-venous injection of 60mg/kg dose of streptozotocin in adult Wistar rats, makes pancreas swell and at last causes degeneration in Langerhans islet beta cells and induces experimental diabetes mellitus in 2-4 days [37]. Both alloxan and STZ have been extensively documented for the induction of diabetes via free radical generation and depletion of antioxidant defense system [38][39][40]. STZ has been reported to significantly decrease the activity of erythrocytes antioxidative enzymes catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) [38][39].…”

Section: Drug-induced Diabetic Mellitus and Their Mechanisms Of Actionmentioning

confidence: 99%

“…Both alloxan and STZ have been extensively documented for the induction of diabetes via free radical generation and depletion of antioxidant defense system [38][39][40]. STZ has been reported to significantly decrease the activity of erythrocytes antioxidative enzymes catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) [38][39]. Several drugs, with pharmacological properties including theophylline, aspirin, isoniazid and nalidixic acid can cause transient hyperglycaemia in over dosage, but only streptozotocin, alloxan and the rodenticide vacor are likely to cause permanent diabetes.…”

Section: Drug-induced Diabetic Mellitus and Their Mechanisms Of Actionmentioning

confidence: 99%

Some Selected Medicinal Plants with Antidiabetic Potentials

Oyagbemi¹,

Salihu²,

Oguntibeju³

et al. 2014

Antioxidant-Antidiabetic Agents and Human Health

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Influence of gallic acid on oxidative stress-linked streptozotocin-induced pancreatic dysfunction in diabetic rats

Abstract: The direct influence and consequent restoration of altered biochemical conditions in the pancreatic tissue of diabetic animal models by GA makes it a promising antidiabetic candidate especially in pancreatic cell regeneration.

Cited by 19 publications

References 51 publications

Chlorophytum borivilianum Root Extract Maintains near Normal Blood Glucose, Insulin and Lipid Profile Levels and Prevents Oxidative Stress in the Pancreas of Streptozotocin-Induced Adult Male Diabetic Rats

Chlorophytum borivilianum Root Extract Maintains near Normal Blood Glucose, Insulin and Lipid Profile Levels and Prevents Oxidative Stress in the Pancreas of Streptozotocin-Induced Adult Male Diabetic Rats

Effect of Caesalpinia bonduc Polyphenol Extract on Alloxan-Induced Diabetic Rats in Attenuating Hyperglycemia by Upregulating Insulin Secretion and Inhibiting JNK Signaling Pathway

Some Selected Medicinal Plants with Antidiabetic Potentials

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