Comparison of probe-based confocal endomicroscopy with virtual chromoendoscopy and white-light endoscopy for diagnosis of gastric intestinal metaplasia

Lim, Lee Yong; Yeoh, Khay Guan; Srivastava, Supriya; Chan, Yiong Huak; Teh, Ming; Ho, Khek Yu

doi:10.1007/s00464-013-3098-x

Cited by 42 publications

(34 citation statements)

References 12 publications

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“…Because the use of CLE becomes more widespread due to the expanding role of CLE in the diagnosis of gastric 17,18 and pancreatic lesions, 19 it may feature more prominently in the diagnostic and management algorithm for IBD in the future. 20 Our study demonstrated that endomicroscopy has enabled for the first time the identification of local barrier dysfunction in the duodenum of patients with CD and UC.…”

Section: Discussionmentioning

confidence: 99%

Confocal Endomicroscopy Identifies Loss of Local Barrier Function in the Duodenum of Patients with Crohnʼs Disease and Ulcerative Colitis

Lim

Neumann²,

Hansen³

et al. 2014

Inflammatory Bowel Diseases

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Section: Discussionmentioning

confidence: 99%

Confocal Endomicroscopy Identifies Loss of Local Barrier Function in the Duodenum of Patients with Crohnʼs Disease and Ulcerative Colitis

Lim

Neumann²,

Hansen³

et al. 2014

Inflammatory Bowel Diseases

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“…A total of 1143 studies were identified after primary literature search, among them 1133 were excluded due to their manuscript types, irrelevant to the topic, duplicates, or with no data on diagnostic efficacy of CLE. Finally, 10 studies fulfilled the inclusion criteria and were eligible in this study . The study selection process is presented in Fig.…”

Section: Resultsmentioning

confidence: 99%

Diagnostic performance of confocal laser endomicroscopy for atrophy and gastric intestinal metaplasia: A meta‐analysis

Bai

Zhang

Sharma

et al. 2017

J of Digest Diseases

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“…Information of per-lesion but not per-patient analyses was provided by all included studies. The CLE and white-light endoscopy were used to diagnose IM in all of included studies plus virtual chromoendoscopy was also performed in one study [24]. Additionally, virtual chromoendoscopy magnifying flexible spectral imaging color enhancement (ME-FICE) and p-CLE were applied to detect GIM in another study [20].…”

Section: Resultsmentioning

confidence: 99%

Diagnostic performance of confocal laser endomicroscopy for optical diagnosis of gastric intestinal metaplasia: a meta-analysis

Liú

Sun

2016

BMC Gastroenterol

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BackgroundGastric intestinal metaplasia (IM) is generally considered as a precancerous condition, a related risk factor for intestinal-type gastric cancer. However, an accurate endoscopic diagnosis of IM is a clinical challenge. Confocal Laser Endomicroscopy (CLE) is a newly technique that can provide real-time magnified images and visualize tissues at cellular or subcellular levels. The aim of this study is to clarify the diagnostic value of CLE in detection of IM in patients at high risk of gastric cancer.MethodsSystematic literature searches up to April 2015 in PubMed, Embase, Web of Science, Cochrane Library databases were conducted by two reviewers independently. The Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool was applied to assess study quality and to reduce potential bias. A meta-analysis using Meta-Disc (version 1.4) and STATA software (version 13) was performed.ResultsA total of four studies enrolled 218 patients and 579 lesions were included in this meta-analysis. On per-lesion basis, the pooled sensitivity and specificity of CLE were 0.97(95 % confidence interval (CI) = 0.94–0.98) and 0.94 (95 % CI = 0.91–0.97) respectively. The pooled positive likelihood ratio (PLR) and negative likelihood ratio (NLR) were 15.20 (95 % CI = 9.46–24.41) and 0.04 (95 % CI = 0.02–0.07) respectively. The pooled diagnostic odds ratio (DOR) was 479.59 (95 % CI = 205.64–1118.51) and summary receiver operating curve (SROC) area under the curve was 0.9884. There was no statistical significance of publication bias.ConclusionCLE is a promising endoscopic tool in the detection of IM with the relatively high diagnostic value in patients at high risk of gastric cancer.

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Comparison of probe-based confocal endomicroscopy with virtual chromoendoscopy and white-light endoscopy for diagnosis of gastric intestinal metaplasia

Abstract: pCLE was superior to AFI and WLE for diagnosing GIM. Off-site review improved performance of pCLE.

Cited by 42 publications

References 12 publications

Confocal Endomicroscopy Identifies Loss of Local Barrier Function in the Duodenum of Patients with Crohnʼs Disease and Ulcerative Colitis

Confocal Endomicroscopy Identifies Loss of Local Barrier Function in the Duodenum of Patients with Crohnʼs Disease and Ulcerative Colitis

Diagnostic performance of confocal laser endomicroscopy for atrophy and gastric intestinal metaplasia: A meta‐analysis

Diagnostic performance of confocal laser endomicroscopy for optical diagnosis of gastric intestinal metaplasia: a meta-analysis

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