Differential roles of hypothalamic serotonin receptor subtypes in the regulation of prolactin secretion in the turkey hen

Bakken, Thomas; Kang, Seong Wook; Kosonsiriluk, Sunantha; Kuwayama, Takehito; Chaiseha, Yupaporn; Halawani, Mohamed E. El

doi:10.1016/j.acthis.2013.06.002

Cited by 3 publications

(4 citation statements)

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“…Moreover, serotonin may act indirectly through DA and VIP as mediators, and it may inhibit or facilitate PRL secretion depending on the 5-HT receptor subtype stimulation ( Chaiseha et al., 2010 ). In female turkeys, PRL appears to be regulated by stimulatory 5-HT 2A/2C and inhibitory 5-HT 1A receptor subtypes residing on DA neurons ( Chaiseha et al, 1998 , Bakken et al, 2014 ). However, as per the study by Bakken et al., (2014) , changes in circulating PRL levels during the reproductive cycle are more dependent on the abundance of inhibitory 5-HT 1A receptors, whose expression changes across the reproductive stages.…”

Section: Discussionmentioning

confidence: 99%

“…In female turkeys, PRL appears to be regulated by stimulatory 5-HT 2A/2C and inhibitory 5-HT 1A receptor subtypes residing on DA neurons ( Chaiseha et al, 1998 , Bakken et al, 2014 ). However, as per the study by Bakken et al., (2014) , changes in circulating PRL levels during the reproductive cycle are more dependent on the abundance of inhibitory 5-HT 1A receptors, whose expression changes across the reproductive stages. In birds, it is well established that the VIP acts directly on the pituitary as a key releasing factor of PRL during the reproductive period.…”

Section: Discussionmentioning

confidence: 99%

“…Both systems are additionally modulated by the monoaminergic pathway involving dopamine ( DA ) and serotonin (5-hydroxytryptamine [ 5-HT ]) ( Chaiseha and El Halawani, 2005 ). In the turkey, two subtypes of 5-HT receptors have been found with a dual role in the regulation of PRL secretion ( Chaiseha et al, 1998 , Bakken et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

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The effect of parachlorophenylalanine treatment on the activity of gonadal and lactotrophic axes in native Polish crested chickens stimulated to broodiness

Gumułka¹,

Hrabia²,

Avital-Cohen³

et al. 2020

Poultry Science

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Brooding behavior, a common characteristic of native breeds of the domestic chicken, is marked by elevated prolactin ( PRL ) levels, which is necessary for incubation and connected with changes in hypothalamic–pituitary–gonadal axis activity. Evidence indicates the serotoninergic system is a potent modulator of PRL secretion. The objective of this study is to investigate whether blocking serotonin synthesis with parachlorophenylalanine ( PCPA ) prevents incubation behavior in native Polish crested chickens. In addition, we examined the effect of PCPA on the gene expression of the gonadal and lactotrophic axes. Birds were stimulated to broodiness by artificial eggs in nests. At 34 wk of age (April: spring period), the hens were divided into 2 groups (14 hens in each group): control and PCPA-treated (50 mg/kg BW) group. After 5 wk of treatment, the artificial eggs were removed from the nests. Egg production, incubation activity, and levels of plasma ovarian steroids progesterone ( P4 ), testosterone ( T ), estradiol ( E2 ), and PRL were examined. At the end of the experiment (45 wk of age, June: summer period), ovarian characteristics and mRNA gene expression of gonadal (gonadotropin-releasing hormone [ GnRH ] I, luteinizing hormone [ LH ] ß, follicle-stimulating hormone [ FSH ] ß) and lactotrophic (vasoactive intestinal peptide [ VIP ], PRL) axes were measured by quantitative real-time PCR. Incubation activity was observed in the hens of both groups but with lower frequency in PCPA-treated birds. Moreover, the PCPA group had a higher cumulative egg production than the controls. During the first six and 8 wk of the experiment, levels of P4 and E2, respectively, were similar in both groups, but all concentrations increased in the PCPA-treated hens after this period. In addition, increased GnRH-I, LHß, and FSHß and decreased VIP mRNA expression was observed in the PCPA group compared with the controls. There were no differences in PRL mRNA expression, the PRL level, and ovarian morphometry between the 2 groups. These results indicate that blockage of serotonin synthesis by PCPA does not effectively prevent incubation in native Polish crested chickens. However, treatment with PCPA increased gonadal axis activity and improved reproductive performance.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The effect of parachlorophenylalanine treatment on the activity of gonadal and lactotrophic axes in native Polish crested chickens stimulated to broodiness

Gumułka¹,

Hrabia²,

Avital-Cohen³

et al. 2020

Poultry Science

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“…Serotonin (5-HT) is a mono-amine inhibitory neurotransmitter, that plays an important role in avian reproduction. Serotonin's effect on reproductive tissues plays a prominent role in gonadotropin secretion (Prasad et al, 2015), prolactin release (El Halawani et al, 1995;Bakken et al, 2014), and steroidogenesis (Niaraki et al, 1982;Frungieri et al, 1999). Serotonin is associated with light exposure (Nakayama et al, 2020) and the effect of photoperiod and temperature can alter the production of serotonin.…”

Section: Introductionmentioning

confidence: 99%

Photoperiodic Changes in Both Hypothalamus Neurotransmitters and Circulating Gonadal Steroids Metabolomic Profiles in Relation to Seasonal Reproduction in Male Quail

Jiang

Liu

et al. 2022

Front. Physiol.

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Both hypothalamic neurotransmitters and serum steroid hormones are impacted by photoperiod and have effects on physiology and seasonal reproductive. However, the relationship between circulating gonadal steroids and hypothalamic neurotransmitters underlying different photoperiod is still unclear. To further understand the crosstalk of neurotransmitters and steroids in seasonal reproduction, metabolic changes of 27 neurotransmitters concentrated in hypothalamus tissues and 42 steroids hormones in serum were assessed during two artificial photoperiodic programs. The results showed that photoperiod induce testicular atrophy and recrudescence. In L-to-S groups, significantly decreased levels of testosterone concentration were found in serum (P < 0.001) and increased 11-Dehydrocorticosterone (P < 0.05); Testosterone were almost undetectable at SD_14d. In addition, the hypothalamus exhibited significantly increased arginine and 4-aminobutyric acid (GABA) concentration and decreased serotonin and epinephrine content (P < 0.01 or P < 0.05). Accordingly, serum testosterone and androstenedione became detectable at LD_3d in the S-to-L group and were markedly increase at LD_7d. Furthermore, Serum androstenedione showed a significant increase with long light expose (P < 0.01). Additionally, the hypothalamus exhibited both significantly increased L.Tryptophan and phenylalanine concentration, as well as decreased L-glutamine and L-glutamine.acid content (P < 0.01 or P < 0.05). Serotonin metabolism showed significant differences between L-to-S group and S-to-L group. Furthermore, in the correlation analysis, serum testosterone had a positive correlation with 5-Hydroxyindole-3-acetic acid (5-HIAA), while Androstenedione was significantly negative with L.Tryptophan in L-to-S (P < 0.05). However, in S-to-L group, serum testosterone showed strong negative correlation with both serotonin and 5-HIAA (P < 0.05), but positive correlation with L.Tryptophan (P < 0.01), while Androstenedione was significantly negative correlation with both serotonin (P < 0.05) and L-Glutamine (P < 0.01). Photoperiod also had significant effects on the mRNA expression. We found significant differences in gene expression patterns of both serotonin signaling and steroid biosynthesis, while MAOB, NR5A1, and 3β-HSD showed an opposite tendency between two groups. Taken together, our results revealed that circulating gonadal steroids and hypothalamic neurotransmitters were significantly impact quail’s seasonal reproduction. Circulating gonadal steroids have different effects on neurotransmitter at different photoperiodism, which may coordinately influence the seasonal reproduction of quails.

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18β-Glycyrrhetinic Acid, a Novel Naturally Derived Agent, Suppresses Prolactin Hyperactivity and Reduces Antipsychotic-Induced Hyperprolactinemia in In Vitro and In Vivo Models

et al. 2016

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The purpose of this study was to examine the effects of 18β-glycyrrhetinic acid (GA), a novel naturally derived agent, in suppressing prolactin (PRL) hyperactivity and reducing antipsychotic-induced hyperprolactinemia (hyperPRL) and the underlying mechanisms in in vitro and in vivo models. GA treatment for 24 h inhibited PRL synthesis and secretion in MMQ cells and cultured pituitary cells in a dose-dependent fashion; but this effect was not reproduced in GH3 cells that lack the expression of functional dopamine D2 receptors. GA suppressed elevated PRL level and growth hormone, and normalized several sex hormones in a rat model of hyperPRL, produced by repeated injection of the dopamine blocker metoclopramide. GA also modulated the expression 5-HT1A and 5-HT2A receptors in both in vivo and in vitro models. These results indicate that GA is effective in suppressing PRL hyperactivity caused by the blockade of dopamine D2 receptors. This suppressive effect of GA may be related to its modulation of the serotonergic system. This study provides additional evidence in support of GA as an adjunct for the treatment of hyperPRL.

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Differential roles of hypothalamic serotonin receptor subtypes in the regulation of prolactin secretion in the turkey hen

Cited by 3 publications

References 38 publications

The effect of parachlorophenylalanine treatment on the activity of gonadal and lactotrophic axes in native Polish crested chickens stimulated to broodiness

The effect of parachlorophenylalanine treatment on the activity of gonadal and lactotrophic axes in native Polish crested chickens stimulated to broodiness

Photoperiodic Changes in Both Hypothalamus Neurotransmitters and Circulating Gonadal Steroids Metabolomic Profiles in Relation to Seasonal Reproduction in Male Quail

18β-Glycyrrhetinic Acid, a Novel Naturally Derived Agent, Suppresses Prolactin Hyperactivity and Reduces Antipsychotic-Induced Hyperprolactinemia in In Vitro and In Vivo Models

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