Use of safety scalpels and other safety practices to reduce sharps injury in the operating room: What is the evidence?

DeGirolamo, Kristin; Courtemanche, Douglas J.; Hill, Warren D.; Kennedy, Angie C.; Skarsgard, Erik D.

doi:10.1503/cjs.003812

Cited by 14 publications

(9 citation statements)

References 20 publications

(19 reference statements)

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“…We suggest, gentle withdrawal of instruments from the nasal cavity and passage of cottonoids and biopsy specimens off the field onto a plastic tray similar to the plastic safe sharps passing tray used for the hands-free transfer or sharps in many operating rooms. 12 There is wide concern within the skull base field regarding aerosol generation and droplets spread during endoscopic endonasal and upper aerodigestive tract surgery. The NOVID system combines a fluid-resistant barrier and a negative pressure environment to reduce the spread of aerosols and droplets.…”

Section: Discussionmentioning

confidence: 99%

Endoscopic skull base and transoral surgery during COVID‐19 pandemic: Minimizing droplet spread with negative‐pressure otolaryngology viral isolation drape

et al. 2020

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Background: The coronavirus disease (COVID-19) pandemic has raised concern of transmission of infectious organisms through aerosols formation in endonasal and transoral surgery.Methods: Retrospective review. We introduce the negative-pressure otolaryngology viral isolation drape (NOVID) system to reduce the risk of aerosol. NOVID consists of a plastic drape suspended above the patient's head and surgical field with a smoke evacuator suction placed inside the chamber. Results: Four patients underwent endonasal (4) and endo-oral surgery (1).Fluorescein was applied to the surgical field. Black light examination of fluorescein-treated operative fields revealed minimal contamination distant to the surgical field. In two prolonged cases with high-speed drilling, droplets were identified under the barrier and on the tip of the smoke evacuator. Instruments and cottonoids appeared to be a greater contributor to field contamination.Conclusions: Negative-pressure aspiration of air under a chamber barrier, which appears to successfully keep aerosol and droplet contamination to a minimum.

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Section: Discussionmentioning

confidence: 99%

Endoscopic skull base and transoral surgery during COVID‐19 pandemic: Minimizing droplet spread with negative‐pressure otolaryngology viral isolation drape

et al. 2020

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“…Accordingly, hASCs isolated from obese patients display a gene expression profile associated with a loss of "stem cellness" and a commitment to adipocyte differentiation [28,29]. This predisposition, combined with a hypoxic environment, may affect hASCs with consequences for mature adipocytes.…”

Section: Hypoxia-related Plasticity Dysfunction In Hascs Correlates Wmentioning

confidence: 99%

Obesity Determines the Immunophenotypic Profile and Functional Characteristics of Human Mesenchymal Stem Cells From Adipose Tissue

Pachón-Peña

Serena

Ejarque

et al. 2016

Stem Cells Translational Medicine

104

109

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Adipose tissue is a major source of mesenchymal stem cells (MSCs), which possess a variety of properties that make them ideal candidates for regenerative and immunomodulatory therapies. Here, we compared the immunophenotypic profile of human adipose-derived stem cells (hASCs) from lean and obese individuals, and explored its relationship with the apparent altered plasticity of hASCs. We also hypothesized that persistent hypoxia treatment of cultured hASCs may be necessary but not sufficient to drive significant changes in mature adipocytes. hASCs were obtained from subcutaneous adipose tissue of healthy, adult, female donors undergoing abdominal plastic surgery: lean (n = 8; body mass index [BMI]: 23 6 1 kg/m 2 ) and obese (n = 8; BMI: 35 6 5 kg/m 2 ). Cell surface marker expression, proliferation and migration capacity, and adipogenic differentiation potential of cultured hASCs at two different oxygen conditions were studied. Compared with lean-derived hASCs, obese-derived hASCs demonstrated increased proliferation and migration capacity but decreased lipid droplet accumulation, correlating with a higher expression of human leukocyte antigen (HLA)-II and cluster of differentiation (CD) 106 and lower expression of CD29. Of interest, adipogenic differentiation modified CD106, CD49b, HLA-ABC surface protein expression, which was dependent on the donor's BMI. Additionally, low oxygen tension increased proliferation and migration of lean but not obese hASCs, which correlated with an altered CD36 and CD49b immunophenotypic profile. In summary, the differences observed in proliferation, migration, and differentiation capacity in obese hASCs occurred in parallel with changes in cell surface markers, both under basal conditions and during differentiation. Therefore, obesity is an important determinant of stem cell function independent of oxygen tension. STEM CELLS TRANSLATIONAL MEDICINE 2016;5:464-475 SIGNIFICANCEThe obesity-related hypoxic environment may have latent effects on human adipose tissue-derived mesenchymal stem cells (hASCs) with potential consequences in mature cells. This study explores the immunophenotypic profile of hASCs obtained from lean and obese individuals and its potential relationship with the altered plasticity of hASCs observed in obesity. In this context, an altered pattern of cell surface marker expression in obese-derived hASCs in both undifferentiated and differentiated stages is demonstrated. Differences in proliferation, migration, and differentiation capacity of hASCs from obese adipose tissue correlated with alterations in cell surface expression. Remarkably, altered plasticity observed in obese-derived hASCs was maintained in the absence of hypoxia, suggesting that these cells might be obesity conditioned.

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“…Međutim, prijavljene prepreke za njihovu uporabu pritužbe su da sigurnosnim skalpelima nedostaje težina te da oštrice nisu tako oštre i ne moge rezati duboko, a percepcija je da sigurnosni skalpeli mogu izazvati više ozljeda. Prema rezultatima mnogih studija, nije nađeno dovoljno dokaza za potporu rutinskog korištenja sigurnosnih skalpela Slika [1] Sigurnosni skalpel [9]. Uporaba sigurnosnih skalpela obvezna je u zemljama s visokim društvenim proizvodom, npr.…”

Section: Ubodni Incidenti U Operacijskoj Dvoraniunclassified

“…Uporaba duplih rukavica smanjuju rizik izloženosti krvi pacijenta za 87%, i to kada pukne vanjska rukavica [11]. Prema danas opće prihvaćenim preporukama [The Society for Healthcare Epidemiologists of America, American College of Surgeons] uporaba dvostrukih rukavica je apsolutno preporučljiva i to kako bi se smanjila izloženost tjelesnim tekućinama pri pucanju rukavice i nastanku ubodnih ozljeda kirurga i djelatnika u operacijskoj dvorani [9,12,13]. Nadalje, treba istaknuti da je količina krvi na igli za šivanje smanjena za 95% kod uboda kroz oba sloja rukavica, tako da se uvelike smanjuje mogućnost unosa virusa u tijelo zdravstvenog djelatnika.…”

Section: Dvostruke Rukaviceunclassified

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Professional exposure and means of protection against sharps injuries in the

Kozina

2016

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Profesionalna izloženost tjelesnim tekućinama u obavljanju svakodnevnih radnih aktivnosti značajan je problem za zdravstvene djelatnike. Nadalje, predstavlja povećani rizik za nastanak infekcija koje se pronose tjelesnim tekućinama [npr. HIV ,hepatitis]. Otkrićem virusa humane imunodeficijencije [HIV] 1981. godine, počele su se razvijati metode prevencije nastanka infekcija kod zdravstvenih djelatnika u operacijskoj dvorani [1]. Centar za kontrolu i prevenciju bolesti [engl. CDC-Centers for Disease Control and Prevention], 1983. godine opisuje

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Use of safety scalpels and other safety practices to reduce sharps injury in the operating room: What is the evidence?

Cited by 14 publications

References 20 publications

Endoscopic skull base and transoral surgery during COVID‐19 pandemic: Minimizing droplet spread with negative‐pressure otolaryngology viral isolation drape

Endoscopic skull base and transoral surgery during COVID‐19 pandemic: Minimizing droplet spread with negative‐pressure otolaryngology viral isolation drape

Obesity Determines the Immunophenotypic Profile and Functional Characteristics of Human Mesenchymal Stem Cells From Adipose Tissue

Professional exposure and means of protection against sharps injuries in the

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