Lifestyle modification decreases arterial stiffness and plasma asymmetric dimethylarginine level in overweight and obese men

Maeda, Seiji; Miyaki, Asako; Kumagai, Hiroshi; Eto, Miki; So, Rina; Tanaka, Kiyoji; Ajisaka, Ryuichi

doi:10.1097/mca.0b013e3283647a99

Cited by 22 publications

(26 citation statements)

References 22 publications

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“…This finding is also supported by our previous publications as well as those from another research group [13][14][15]. In obese people, increased circulating cholesterol, triglycerides and insulin are associated with elevated arterial stiffness.…”

Section: -24]supporting

confidence: 79%

“…A previous study demonstrated that anti-inflammatory medication decreased arterial stiffness in rheumatoid patients who had high circulating levels of pro-inflammatory factors [12]. We and other research groups have shown that weight-loss caused by lifestyle modifications reduced arterial stiffness in obese individuals [13][14][15][16]. However, there have been no reports regarding obese individuals and the effect of weight-loss on the change in several types of inflammatory factors, as a mechanism for decreased arterial stiffness.…”

mentioning

confidence: 85%

“…The participants participated in an aerobic exercise class for up to 90 min/day, 3 times per week for 12 weeks as previously described [13,14,17,18]. In addition, the participants were instructed to perform exercise training by themselves at least once each week.…”

Section: Aerobic Exercise Trainingmentioning

confidence: 99%

“…Participants were placed on a dietary restriction of 1,680 kcal per day, which was maintained through a nutritionally balanced diet restriction program consisting of 12 weekly lectures, as previously described [13,14,16,17]. During the 12-week intervention period, the participants maintained food diaries that were monitored by dieticians who provided recommendations at the weekly lectures.…”

Section: Dietary Modificationsmentioning

confidence: 99%

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Which cytokine is the most related to weight loss-induced decrease in arterial stiffness in overweight and obese men?

et al. 2018

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Abstract. Obesity and increased arterial stiffness are risk factors for cardiovascular disease. A well-known characteristic of obesity is the chronic low-grade inflammatory state, and it causes elevation of arterial stiffness. Weight-loss reduces arterial stiffness and inflammatory level in obese individuals. However, it is unclear which inflammatory factor is most related to weight loss-induce decreases in arterial stiffness in overweight and obese men. Thus, the aim of this study was to determine which circulating cytokine level has the most effect on decreasing arterial stiffness after lifestyle modification. Twenty overweight and obese men completed a 12-week period of lifestyle modifications (combination of aerobic exercise training and dietary modification). We measured brachial-ankle pulse wave velocity (baPWV) as an index of arterial stiffness, and circulating cytokine levels using comprehensive analysis. After the 12-week lifestyle modifications, body mass was markedly decreased. Also, baPWV and the levels of several circulating cytokines significantly decreased after the lifestyle modifications. We observed a positive correlation between changes in baPWV and circulating interleukin-6 (IL-6) levels. Furthermore, multiple liner regression analysis revealed that change in baPWV was significantly associated with that in IL-6 levels after consideration of changes in systolic blood pressure and body mass index. These results suggest that for overweight and obese men, a 12-week period of lifestyle modifications-induced a decrease in circulating cytokine levels (especially IL-6 levels), leads to decreased baPWV.

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Section: -24]supporting

confidence: 79%

mentioning

confidence: 85%

Section: Aerobic Exercise Trainingmentioning

confidence: 99%

Section: Dietary Modificationsmentioning

confidence: 99%

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Which cytokine is the most related to weight loss-induced decrease in arterial stiffness in overweight and obese men?

et al. 2018

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“…However, about 46% of primary care patients at risk for diabetes did not do physical activity per week [40]; while two-third of patients with diabetes remain inactive [64]. It has been recommended that moderate to vigorous physical activity can reduce the risk of chronic diseases such as diabetes and its complications [65][66][67]. Health counsellors should address these barriers to increase the patients' adherence to physical activity as the recommendations [41].…”

Section: Discussionmentioning

confidence: 99%

Principal Component Regression Analysis of Nutrition Factors and Physical Activities with Diabetes

Wang¹,

Liu²,

Xie³

et al. 2017

J Biom Biostat

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The associations of nutrition factors and physical activities with adult diabetes are inconsistent; while most of these factors are inter correlated. The aims of this study are to overcome the disturbance of the multicollinearity of the risk factors and examine the associations of these factors with diabetes using the principal component analysis (PCA) and regression analysis with principal component scores (PCS). Totally, 659 adults with diabetes and 2827 non-diabetic were selected from the 2012 Health Information National Trends Survey (HINTS 4, Cycle 2). PCA was utilized to deal with multicollinearity of the risk factors. Weighted univariate and multiple logistic regression analyses were used to estimate the associations of potential factors and PCS with diabetes. The odds ratios (ORs) with 95% confidence intervals (CIs) were estimated. The first 3 PCs for nutrition factors and physical activities could explain 70% variances. The first principal component (PC 1 ) is a measure of nutrition factors (fruit and vegetables consumption), PC 2 is a measure for physical activities (moderate exercise and strength training), and PC3 is about calorie information use and soda use. Weighted multiple logistic regression showed that African Americans, middle aged adults (45-64 years), elderly (65+), never married, and with lower education were associated with increased odds of diabetes. After adjusting for others factors, the PC 1 showed marginal association with diabetes (OR=0.84, 95% CI=0.70-1.01); while PC 2 and PC 3 revealed significant associations with diabetes (OR=0.73, 95% CI=0.61-0.86 and OR=0.85, 95% CI=0.74-0.99, respectively). In conclusion, PCA can be used to reduce the indicators in complex survey data. The first 3 PCs of nutrition factors and physical activities were associated with diabetes. Promotion of health food and physical activities should be encouraged to help decrease the prevalence of diabetes.

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Serum Concentrations of New Predictive Cardiovascular Disease Biomarkers in Mexican Women Exposed to Lead

Ochoa-Martínez¹,

Cardona-Lozano

Carrizales-Yáñez

et al. 2017

Arch Environ Contam Toxicol

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The purpose of this study was to evaluate lead exposure and its relationship with serum levels of predictive CVD biomarkers [asymmetric dimethylarginine (ADMA), adipocyte fatty acid-binding protein (FABP4), adiponectin, and chemerin] in women living in San Luis Potosi, Mexico. A mean blood lead level (BLL) of 11.5 ± 9.00 μg/dL (mean ± standard deviation) was found after all blood samples were analyzed. Regarding serum predictive CVD biomarkers, mean serum level of 0.68 ± 0.38 μmol/L, 20.5 ± 16.5 ng/mL, 12.5 ± 3.30 μg/mL, and 255 ± 130 ng/mL were found for ADMA, FABP4, adiponectin, and chemerin, respectively. Simple significant associations (Pearson´s correlations) between BLL and ADMA (r = 0.17; p = 0.04) and FABP4 (r = 0.23; p = 0.03) were found. Furthermore, a multivariate linear regression model showed that BLL was a significant predictor of serum ADMA (β = 0.06; p = 0.001) and FABP4 (β = 1.75; p = 0.0004) concentrations after adjusting by confounders. For serum chemerin and adiponectin levels, no associations were found with BLL. In conclusion, high serum ADMA and FABP4 (predictive CVD biomarkers) levels were found in women exposed to lead. Consequently, this research can be used as a point of departure for the prevention of CVD events in populations living in sites environmentally impacted with lead.

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Lifestyle modification decreases arterial stiffness and plasma asymmetric dimethylarginine level in overweight and obese men

Cited by 22 publications

References 22 publications

Which cytokine is the most related to weight loss-induced decrease in arterial stiffness in overweight and obese men?

Which cytokine is the most related to weight loss-induced decrease in arterial stiffness in overweight and obese men?

Principal Component Regression Analysis of Nutrition Factors and Physical Activities with Diabetes

Serum Concentrations of New Predictive Cardiovascular Disease Biomarkers in Mexican Women Exposed to Lead

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