Brucellosis and tuberculosis: Clinical overlap and pitfalls

Dasari, Sowjanya; Naha, Kushal; Prabhu, Mukhyaprana

doi:10.1016/s1995-7645(13)60145-5

Cited by 28 publications

(24 citation statements)

References 13 publications

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“…The disease in humans results from ingestion or inhalation of the pathogen, or direct entrance via skin abrasions [8]. Humans can get the disease through consumption of raw milk and raw milk products from infected animals and via direct handling with contaminated materials from infected animals, specifically in aborted foetuses, foetal membranes and vaginal secretions.…”

Section: Introductionmentioning

confidence: 99%

Knowledge, attitudes and practices (KAP) relating to brucellosis in smallholder dairy farmers in two provinces in Pakistan

et al. 2017

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The present study aimed to assess the extent of knowledge and understanding of brucellosis in smallholder dairy farmers and identify practices at the farm and household level that might pose a risk for humans contracting brucellosis. Between February and June 2015 a cross-sectional study was conducted among smallholder farms (n = 420) in five districts of Punjab and two districts of Sindh province. Farmers were interviewed using a questionnaire to obtain information on farmers’ knowledge about brucellosis and the potential risks for contracting the disease that are present for dairy farmers and their families. Logistic regression and ordinal logistic models were used to investigate potential predictors for risky behaviours. The results show almost all farmers (97%) were not aware of the modes of transmission of brucellosis. Relating to risk, the majority (66%) of the farmers’ families were reported to consume raw milk and its products, live in shared housing with animals (49%) and not cover hand cuts during contact with animals (74%). All farmers performed at least one risky practice on a regular basis for brucellosis transmission from animal to human. A multivariable analysis highlighted that the respondents with no formal education and those who had not heard of the disease displayed greater risky behaviour. Poor understanding of the disease, presence of multiple risky practices on farm and at the household, and incorrect perception supports the need for an educational awareness program in order to ensure uptake of improved practices.

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Section: Introductionmentioning

confidence: 99%

Knowledge, attitudes and practices (KAP) relating to brucellosis in smallholder dairy farmers in two provinces in Pakistan

et al. 2017

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“…TB and BS are infectious diseases endemic in certain areas of the world, generally in developing countries (2,7,18) and are relatively common causes of vertebral osteomyelitis (19). Due to similarities in clinical presentation and basic laboratory parameters, a proportion of patients may be misdiagnosed with either TB or BS (18).…”

Section: Discussionmentioning

confidence: 99%

“…Due to similarities in clinical presentation and basic laboratory parameters, a proportion of patients may be misdiagnosed with either TB or BS (18). Despite extensive efforts to control TB, it remains an urgent global health problem, particularly due to the spread of HIV and emergence of multi-drug resistant TB.…”

Section: Discussionmentioning

confidence: 99%

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Diagnosis and management of spinal tuberculosis combined with brucellosis: A case report and literature review

2018

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Abstract. Tuberculosis combined with brucellosis is a very rare condition. Overlapping clinical presentation and laboratory parameters of tuberculosis and brucellosis may lead to misdiagnosis or delayed diagnosis of the condition. The current study presents the case of a 45-year-old male with symptoms of lower back pain, non-tender swelling in the right flank, intermittent hyperpyrexia, sweating, body aches and numbness and weakness of right lower limb. A lumbar computed tomograph (CT) scan and magnetic resonance imaging indicated vertebral destruction and the formation of sequestra and thecal sac compression. Tuberculosis was suspected, but subsequent culture of blood and pus revealed the co-infection of Mycobacterium tuberculosis and Brucella melitensis. The patient was treated with antibiotics, CT-guided percutaneous drainage of the abscess and posterior approach decompression, debridement, instrumentation and fusion. Co-existence of spinal tuberculosis and brucellosis is rare and clinicians should strengthen the awareness of such conditions in similar patients. CT-guided percutaneous drainage is effective in the diagnosis and management of spinal tuberculosis with abscess.

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“…El uso extensivo de ambos antimicrobianos para el tratamiento contra brucelosis podría generar resistencia en las micobacterias por lo que ya no serían efectivos en casos de tuberculosis. Ésta es una problemática que los epidemiólogos tendrán que tomar en cuenta en el tratamiento de casos humanos en zonas endémicas de brucelosis y tuberculosis 32 . Los antimicrobianos, suministrados a los pacientes de este seguimiento, fueron la combinación de dos antimicrobianos recomendados por OMS desde 1986, y establecidos por NOM-022-SSA2-2012.…”

Section: Wwwsochinfclunclassified

Seguimiento clínico, serológico y mediante la reacción de polimerasa en cadena de una familia con brucelosis

Morales-García¹,

García-Méndez²,

Regalado-Jacobo³

et al. 2014

Rev. chil. infectol.

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Brucellosis and tuberculosis: Clinical overlap and pitfalls

Cited by 28 publications

References 13 publications

Knowledge, attitudes and practices (KAP) relating to brucellosis in smallholder dairy farmers in two provinces in Pakistan

Knowledge, attitudes and practices (KAP) relating to brucellosis in smallholder dairy farmers in two provinces in Pakistan

Diagnosis and management of spinal tuberculosis combined with brucellosis: A case report and literature review

Seguimiento clínico, serológico y mediante la reacción de polimerasa en cadena de una familia con brucelosis

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