Quantitative assessment of the association between CYP1A1 A4889G polymorphism and endometrial cancer risk

Abstract

Cytochrome P450 1A1 (CYP1A1) A4889G polymorphism was supposed to be associated with endometrial cancer risk, but previous studies reported conflicting results. We therefore performed a meta-analysis of all relevant studies to get a comprehensive assessment of the association between CYP1A1 A4889G polymorphism and endometrial cancer risk. The pooled odds ratios (OR) with the corresponding 95% confidence interval (95% CI) was calculated to assess the association. Finally, ten studies with a total of 1,682 endometrial cancer cases and 2,510 controls were finally included into the meta-analysis. Meta-analysis of the total ten studies showed that CYP1A1 A4889G polymorphism was not associated with endometrial cancer risk (ORG versus A = 1.14, 95% CI 0.83-1.57, P OR = 0.417; ORGG versus AA = 1.23, 95% CI 0.70-2.18, P OR = 0.470; ORGG versus AA/AG = 1.03, 95% CI 0.59-1.81, P OR = 0.919; ORGG/AG versus AA = 1.22, 95% CI 0.82-1.81, P OR = 0.336). Subgroup analyses by ethnicity further showed that there was also no obvious association between CYP1A1 A4889G polymorphism and endometrial cancer risk in both Caucasians and Asians. Sensitivity analysis by excluding single study in turns showed that the pooled estimations were not stable. Therefore, evidence for currently available data suggests that CYP1A1 A4889G polymorphism is not associated with endometrial cancer risk. However, more studies with large number of participants are needed to further assess the association precisely.

CYP1A1 Gene Polymorphism and Breast Cancer

“…2017; 15(2):e63399. (10). In 2012, Sergentanis analyzed the relationship of this polymorphism of CYP1A1 with ovarian cancer and he informed no association (11), and in 2001 in a research by Basham, after analysis of 1873 patients with breast cancer and 712 control cases, similar to the current study, he reported that there was no association between Thr461Asn polymorphism of CYP1A1 and breast cancer (5).…”

Letter regarding Li et al. entitled “Quantitative assessment of the association between CYP1A1 A4889G polymorphism and endometrial cancer risk”

“…Moreover, more carefully and scientifically designed studies with large samples are still needed. I believe that these remarks will contribute to further, more accurate elaboration and substantiation of the original results presented by Li et al [1].…”

“…Received: 22 August 2013 / Accepted: 23 September 2013 / Published online: 6 October 2013 # International Society of Oncology and BioMarkers (ISOBM) 2013 To the Editor, In a recent issue of Tumor Biology, Li and his workmates published an article [1] entitled "Quantitative assessment of the association between CYP1A1 A4889G polymorphism and endometrial cancer risk." In this study, the authors performed a meta-analysis to a quantitative assessment of the association between CYP1A1 A4889G polymorphism and endometrial cancer risk.…”

Association of genetic predisposition studies in CYP1A1 polymorphism studies in acute myeloid leukemia

“…The A4889G is one of the polymorphisms in CYP1A1 gene is considered to be drug metabolizing enzymes which is contributing to the susceptibility of human diseases precisely in leukemias and cancers. Previous studies have contributed towards cancers ( Oliveira et al, 2012 , Cardoso-Filho et al, 2013 , Li et al, 2013 , Oliveira et al, 2013 , Oliveira et al, 2015 ) as well as leukemias ( Krajinovic et al, 2002 , Barragan et al, 2007 , Yamaguti et al, 2010 , Swinney et al, 2011 , Cardoso-Filho et al, 2013 , Lakkireddy et al, 2015 , Zou et al, 2015 , Zou et al, 2016 ). However, a meta -analysis study was documented studied between A4889G polymorphism and AML ( Vijayakrishnan and Houlston, 2010 ).…”