Magnetic resonance imaging of temporomandibular joint dysfunction-correlation with clinical symptoms, age, and gender

Lamot, Urška; Strojan, Primož; Popović, Katarina

doi:10.1016/j.oooo.2013.04.019

Cited by 50 publications

(20 citation statements)

References 18 publications

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“…In this age group, TMJ dysfunction is quite common in the general population, and the dysfunction is frequently related to disc displacement and osteoarthritis. 80,81 Similar observations are made in the pediatric age group. 82,83 In adults, adolescents, and children such TMJ dysfunction may be a differential diagnostic challenge to JIA TMJ involvement.…”

Section: Differential Diagnosessupporting

confidence: 75%

TMJ imaging in JIA patients—An overview

Larheim

Doria

Kirkhus

et al. 2015

Seminars in Orthodontics

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Section: Differential Diagnosessupporting

confidence: 75%

TMJ imaging in JIA patients—An overview

Larheim

Doria

Kirkhus

et al. 2015

Seminars in Orthodontics

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“…Like other joints, the TMJ degenerates with age 4, 5 . However, women between the ages of 44–55 years are most likely to seek treatment 6, 7 , suggesting a role for estrogen in the disease process.…”

Section: Introductionmentioning

confidence: 99%

Estrogen via estrogen receptor beta partially inhibits mandibular condylar cartilage growth

Chen

Kamiya

Polur

et al. 2014

Osteoarthritis and Cartilage

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Objective Temporomandibular joint diseases predominantly afflict women, suggesting a role for female hormones in the disease process. However, little is known about the role of estrogen receptor (ER) signaling in regulating mandibular condylar cartilage growth. Therefore, the goal of this study was to examine the effects of altered estrogen levels on the mandibular condylar cartilage in WT and ER beta KO mice. Materials and Methods 21-day-old female WT (n=37) and ER beta KO mice (n=36) were either sham operated or ovariectomized, and treated with either placebo or estradiol. The mandibular condylar cartilage was evaluated by histomorphometry, proliferation was analyzed by double EdU/BrdU labeling, and assays on gene and protein expression of chondrocyte maturation markers were performed. Results In WT mice, ovariectomy caused a significant increase in mandibular condylar cartilage cell numbers, a significant increase in Sox9 expression and a significant increase in proliferation compared with sham operated WT mice. In contrast, ovariectomy did not cause any of these effects in the ER beta KO mice. Estrogen replacement treatment in ovariectomized WT mice caused a significant decrease in ER alpha expression and a significant increase in Sost expression compared with ovariectomized mice treated with placebo. Estrogen replacement treatment in ovariectomized ER beta KO mice caused a significant increase in Col2 expression, no change in ER alpha expression, and a significant increase in Sost expression. Conclusion Estrogen via ER beta inhibits proliferation and ER alpha expression while estrogen independent of ER beta induces Col2 and Sost expression.

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“…Disc displacement, joint effusion, mandibular condyle and marrow abnormalities can be better assessed using MRI [9]. MRI morphological manifestations of TMJ are shown to correlate well with symptoms and confirms the value of MRI in the diagnosis of TMD [10]. However, studies have shown that the diagnostic accuracy of MRI in relation to disc tear is only around 50% compared with surgical findings at arthroscopy or open surgery [11].…”

Section: Diagnostic Methodsmentioning

confidence: 74%

Current Management of Temporomandibular Joint (TMJ) Disease

Farook¹

2014

J Arthritis

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Temporomandibular joint (TMJ) disorder (TMD) is a collection of medical and dental conditions affecting the joint and muscles of mastication, as well as contiguous tissue components. This leads to pain and altered oral function and can lead to a poor quality of life. The majority of the population can be affected to some degree. Management of TMD is often simple in the first instance, but may involve complex decision making. This article summarizes the current investigative and treatment options available.Magnetic Resonance Imaging is the recommended radiological investigation of choice for soft tissue assessment whilst TMJ arthroscopy supersedes most other invasive treatments available in relation management of symptoms and more accurate diagnosis. Should arthroscopy fail to achieve satisfactory resolution of symptoms a standardised treatment pathway based on arthroscopic findings involves appropriate assessment, possible open surgery or even TMJ replacement. This latter procedure is governed by NICE guidelines and delivers an excellent short and medium term outcome up to 20 years.

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Magnetic resonance imaging of temporomandibular joint dysfunction-correlation with clinical symptoms, age, and gender

Cited by 50 publications

References 18 publications

TMJ imaging in JIA patients—An overview

TMJ imaging in JIA patients—An overview

Estrogen via estrogen receptor beta partially inhibits mandibular condylar cartilage growth

Current Management of Temporomandibular Joint (TMJ) Disease

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