Increased asthma risk and impaired quality of life after bronchiolitis or pneumonia in infancy

Backman, Katri; Piippo-Savolainen, Eija; Ollikainen, Hertta; Koskela, Heikki; Korppi, Matti

doi:10.1002/ppul.22842

Cited by 43 publications

(96 citation statements)

References 41 publications

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“…2,3,23,24 However, many prospective cohorts have demonstrated that early-childhood wheezers have an increased risk of suffering from asthma later in childhood, 15,16,[25][26][27][28][29] adolescence, 4,17,30,31 and even in adulthood. 2,3,23,24 However, many prospective cohorts have demonstrated that early-childhood wheezers have an increased risk of suffering from asthma later in childhood, 15,16,[25][26][27][28][29] adolescence, 4,17,30,31 and even in adulthood.…”

Section: Discussionmentioning

confidence: 99%

Asthma and lung function in adulthood after a viral wheezing episode in early childhood

Backman

Ollikainen²,

Piippo-Savolainen

et al. 2017

Clin Experimental Allergy

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Section: Discussionmentioning

confidence: 99%

Asthma and lung function in adulthood after a viral wheezing episode in early childhood

Backman

Ollikainen²,

Piippo-Savolainen

et al. 2017

Clin Experimental Allergy

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“…Poor housing, with overcrowding, provides a potent milieu for repeated exposure and infection with viral respiratory pathogens. There is mounting evidence that this impact may be long lasting, with a higher risk of asthma and lower respiratory health‐related quality of life …”

Section: Discussionmentioning

confidence: 99%

Respiratory health inequality starts early: The impact of social determinants on the aetiology and severity of bronchiolitis in infancy

Foley

Best

Reid

et al. 2018

J Paediatrics Child Health

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Aim To define the impact of demographics on the incidence, aetiology and clinical course of viral bronchiolitis in infants younger than 2 years of age. Methods Retrospective case review of all viral bronchiolitis admissions for patients aged younger than 2 years old from January 1 2014 to 31 December 2015 at Wellington Regional Hospital, New Zealand. Demographic data, second‐hand smoke exposure (SHSE) and presence of predisposing conditions were collected, along with outcome data including use of respiratory support and intensive care unit (ICU) admission. This was compared to background rates calculated from regional census data. Results There were 556 admissions included (11% of paediatric medical admissions); 49% tested positive for respiratory syncytial virus (RSV) (84% tested), and 40% of admissions received positive pressure respiratory support and 10% ICU admission. Admission rates ranged from 9.6 to 77 per 1000/year, with higher rates seen in those from areas of high deprivation. Admission rates by deprivation varied according to aetiology. RSV‐positive admission rates increased from 9.7 per 1000/year to 24.6 per 1000/year in the least to most deprived areas, whereas non‐RSV admissions showed even greater disparity, increasing from 10.1 per 1000/year to 37.5 per 1000/year (both P < 0.0001). Conclusions This study further reinforces that material deprivation contributes significantly to poor health outcomes that are apparent in infancy. SHSE is a potent risk factor for adverse respiratory outcomes in this patient population. Ongoing efforts to eradicate smoking and reduce material inequality need to continue.

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“…Although prospective studies of virologically confirmed RSV infection followed to adult life are limited and the link between RSV and adult asthma remains obscure, longterm studies in Finland demonstrated an increase in asthma prevalence in adulthood after severe bronchiolitis in infancy (13). In a group of children younger than 2 years of age hospitalized for bronchiolitis or pneumonia in which RSV was detected in 40% of cases, 25% of children reported asthma at ages 4-6 years as compared with only 12-15% at ages 8-15, but prevalence of asthma rose to 30% at ages 18-20 and up to 35% at age 30 (14)(15)(16)(17)(18) . Similar results were reported by this research group when specifically considering subjects hospitalized with bronchiolitis caused by RSV; asthma risk was not elevated during the second decade of life, yet increased in the third decade (27,28).…”

Section: Discussionmentioning

confidence: 99%

“…In the longest ongoing longitudinal study of young children hospitalized with LRI in the first 2 years of life, 40% of whom were infected with RSV, prevalence of asthma decreased from 25% at age 4.5-6 years to 12-15% at ages 8-15, only to increase again to 30% at age 18-20 and up to 35% at age 30 (14)(15)(16)(17)(18). There was no clear explanation for this trend but the authors noted that, surprisingly, adults with a history of LRI were more likely to smoke than control subjects (18).…”

mentioning

confidence: 99%

Risk of Current Asthma among Adult Smokers with Respiratory Syncytial Virus Illnesses in Early Life

Voraphani

Stern

Wright

et al. 2014

Am J Respir Crit Care Med

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Rationale: Risk of subsequent asthma-like symptoms after early-life lower respiratory illness (LRI) caused by respiratory syncytial virus (RSV) is increased during the first decade of childhood and diminished thereafter by adolescence.Objectives: To determine the relation of early-life RSV-LRI on adult asthma-like symptoms and its interactive role with adult smoking.Methods: A total of 1,246 nonselected infants were enrolled at birth and prospectively followed. Virologically confirmed RSV-LRIs were assessed during the first 3 years of life. At age 22, 24, 26, and 29 years, current asthma and smoking behavior were evaluated by questionnaire. Peak flow variability was assessed at age 26 and expressed as amplitude % mean. A longitudinal analysis was used to investigate the relation of RSV-LRI and active smoking to adult outcomes.Measurements and Main Results: Neither RSV-LRI nor active smoking were directly associated with increased current adult asthma or peak flow variability. However, there was a significant interaction between RSV-LRI and active smoking in relation to current asthma (P for interaction = 0.004) and peak flow variability (P for interaction = 0.04). Among subjects with early RSV-LRI, those who actively smoked were 1.7 times more likely to have current asthma (95% confidence interval, 1.2-2.3; P = 0.003) and had greater amplitude % mean (10.0% vs. 6.4%; P = 0.02) than nonsmokers. Among subjects without early RSV-LRI, there was no difference in asthma risk or peak flow variability between active smokers and nonsmokers.Conclusions: Smoking is associated with increased risk of having asthma in young adults who had RSV-LRI in early life but not among subjects without these illnesses.

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Increased asthma risk and impaired quality of life after bronchiolitis or pneumonia in infancy

Cited by 43 publications

References 41 publications

Asthma and lung function in adulthood after a viral wheezing episode in early childhood

Asthma and lung function in adulthood after a viral wheezing episode in early childhood

Respiratory health inequality starts early: The impact of social determinants on the aetiology and severity of bronchiolitis in infancy

Risk of Current Asthma among Adult Smokers with Respiratory Syncytial Virus Illnesses in Early Life

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