Is Routine Appendectomy at the Time of Primary Surgery for Mucinous Ovarian Neoplasms Beneficial?

Feigenberg, Tomer; Covens, Allan; Ghorab, Zeina; Ismiil, Nadia; Dubé, Valérie; Khalifa, Mahmoud A.; Nofech‐Mozes, Sharon

doi:10.1097/igc.0b013e31829b7dca

Cited by 29 publications

(10 citation statements)

References 12 publications

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“…Despite the substantial advances in surgery and chemotherapy for ovarian cancer over the last few decades21222324, therapeutic failure and disease progression are still quite frequent25. Searching for novel and validated biomarkers correlated with the clinical and prognostic characteristics of ovarian cancer is important for diagnosis and treatment.…”

Section: Discussionmentioning

confidence: 99%

ROR1 expression correlated with poor clinical outcome in human ovarian cancer

Zhang

Qiu

et al. 2014

Sci Rep

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The receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a transmembrane protein belongs to receptor tyrosine kinase (RTK) family. This study aimed to examine the expression of ROR1 in human ovarian cancer and investigate the relationship between its expression and the prognosis of ovarian cancer patients. In this present study, one-step quantitative reverse transcription-polymerase chain reaction (15 ovarian cancer samples of high FIGO stage, 15 ovarian cancer samples of low FIGO stage and nine normal ovary tissue samples) and immunohistochemistry by tissue microarrays (100 ovarian cancer samples and 50 normal ovary samples) were performed to characterize expression of the ROR1 gene in ovarian cancer. Kaplan-Meier survival and Cox regression analyses were executed to evaluate the prognosis of ovarian cancer. The results of qPCR and IHC analysis showed that the expression of ROR1 in ovarian cancer was significantly higher than that in normal ovary tissues (all p < 0.05). Survival analysis showed that ROR1 protein expression was one of the independent prognostic factors for disease-free survival and overall survival (both p < 0.05). The data suggest that ROR1 expression is correlated with malignant attributes of ovarian cancer and it may serve as a novel prognostic marker in ovarian cancer.

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Section: Discussionmentioning

confidence: 99%

ROR1 expression correlated with poor clinical outcome in human ovarian cancer

Zhang

Qiu

et al. 2014

Sci Rep

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“…Two other groups found only malignant involvement of the appendix in 155 and 36 cases, respectively, when the appendix was grossly abnormal and recommend that only grossly abnormal appendices be removed. 7,8 In a very recent publication of 35 patients with mucinous ovarian cancer, 29 had appendectomy performed. In 21 of the cases, the appendix was macroscopically normal, and histology was normal in 20 cases (95%), and 1 patient had a serrated adenoma.…”

Section: Figurementioning

confidence: 99%

The Importance of Appendectomy in Surgery for Mucinous Adenocarcinoma of the Ovary

Rosendahl¹,

Oester

Høgdall

2017

International Journal of Gynecological Cancer

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“…Among these patients, 55 were at stage I and 11 patients were at stage III. Fifty-five patients had no pathologic evidence of appendiceal involvement by tumor, as authors could not establish documentation of necessary appendectomy at an early stage of tumor (10). The study of Fontanelli et al on 160 patients with ovarian mucinous tumor undergoing concurrent appendectomy showed that 120 patients were at stage I and stage II without pathologic evidence of appendiceal involvement (19).…”

Section: Discussionmentioning

confidence: 99%