The Impact of Combined Antiretroviral Therapy on Biologic False-Positive Rapid Plasma Reagin Serologies in a Longitudinal Cohort of HIV-Infected Persons

Oboho, Ikwo; Gebo, Kelly A.; Moore, Richard D.; Ghanem, Khalil G.

doi:10.1093/cid/cit445

Cited by 17 publications

(11 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For the state of Santa Catarina, 95% of approximately 25% of the remaining Atlantic Rainforest cover is secondary forest [61,62]. The natural resources of secondary forests are important to local communities, and abandonment of fields for forest regeneration does not make them idle and unproductive spaces [63-66].…”

Section: Discussionmentioning

confidence: 99%

Use of the palm Euterpe edulismartius in landscape units managed by migrants of German origin in Southern Brazil

Milanesi

Peroni

Reis

2013

J Ethnobiology Ethnomedicine

View full text Add to dashboard Cite

BackgroundPeople influence their environments through the manipulation of landscapes and species. Human influence on the landscape may lead to the development of differentiated landscape units that originate from past use and may be related to the presence of certain species. This study investigated the presence of the palm Euterpe edulis and its current and past importance in landscape units established by a community of German descendants located in southern Brazil. The objectives of this study were to characterize the use of the species, to identify the importance of E.edulis for the German immigrant community, to identify past and current uses of E.edulis, to describe the historical use of the landscape, and lastly, to identify landscape units in which E.edulis is found.MethodsThe researched community is composed of people of German descent residing in southern Brazil. A variety of research tools were used to achieve the objectives of the research. Semi-structured interviews and free-listings were conducted in all family units. The interviews focused on groups of people in the community who had current or historical connection with the species. Group workshops and guided tours were conducted to identify different landscape units. The data were analyzed using descriptive statistics, use-value index, citation frequency, salience index, and informant perception analysis.ResultsOver the historical period studied, the community demonstrated changes with respect to economic activities. These changes are reflected in the transformation of the landscape. The species E.edulis was and still is very important for people in the community; its importance is reflected in its high use value, citation frequency and salience. The species is found within various landscape units in the community as well as in homegardens and in secondary forests.ConclusionsThe landscape heterogeneity of this community is influenced by changes in economic activities and by the relationship with the conservation unit. Landscape units resulting from this relationship may be identified. The species E.edulis is found within these landscape units and is integrated into the livelihood of the community.

show abstract

Section: Discussionmentioning

confidence: 99%

Use of the palm Euterpe edulismartius in landscape units managed by migrants of German origin in Southern Brazil

Milanesi

Peroni

Reis

2013

J Ethnobiology Ethnomedicine

View full text Add to dashboard Cite

show abstract

“…All reactive non-treponemal tests were confirmed using treponemal tests, thereby minimizing the risk of false-positive test results. Of note, the use of cART appears to decrease the prevalence of biologic false-positive tests in HIVinfected individuals (31). Also, all patient files were reviewed, enabling us to confirm that seroreactive tests were clinically perceived as a case and to distinguish between relapse and re-infection.…”

Section: Discussionmentioning

confidence: 99%

Serological Response to Treatment of Syphilis with Doxycycline Compared with Penicillin in HIV-Infected Individuals

Salado-Rasmussen¹,

Hoffmann²,

Cowan³

et al. 2014

Acta Derm Venerol

View full text Add to dashboard Cite

Serological response to treatment of syphilis with orally administered doxycycline or intramuscularly administered penicillin was assessed in patients with concurrent HIV. All HIV-infected individuals diagnosed with syphilis attending 3 hospitals in Copenhagen, Denmark were included. Odds ratios (ORs) with 95% confidence intervals (CI) associated with serological outcome were modelled using propensity-score-adjusted logistic regression analysis. In total, 202 cases were treated with doxycycline or intramuscular penicillin. At 12 months, serological failure was observed in 12 cases (15%) treated with doxycycline and in 8 cases (17%) treated with penicillin (OR 0.78 (95% CI 0.16-3.88), p = 0.76). The serological cure rate at 12 months was highest in patients with primary syphilis (100%), followed by patients with secondary (89%), early latent (71%) and late latent (67%) syphilis (p = 0.006). In conclusion, this study provides evidence for the use of doxycycline as a treatment option when treating a HIV-infected population for syphilis.

show abstract

“…(The use of darkfield microscopy for the diagnosis of early syphilis using specimens from genital lesions, and the use of PCR testing on these lesions, which is even more sensitive, are rarely performed outside of specialized settings). The reliance on these indirect tests that may not necessarily reflect underlying disease activity has generated significant challenges in the management of syphilis [ 28 ].…”

Section: Reviewmentioning

confidence: 99%

Emerging trends and persistent challenges in the management of adult syphilis

Tuddenham

Ghanem

2015

BMC Infect Dis

View full text Add to dashboard Cite

There are an estimated 10.6 million incident cases of syphilis worldwide each year. We highlight some persistent challenges and emerging trends in the clinical management of syphilis with a particular focus on therapy, serology, diagnostics, and prevention. Decades after the introduction of penicillin, the optimal management of early syphilis continues to be a controversial topic, particularly in the setting of HIV co-infection. Similarly, the need for routine lumbar puncture in HIV co-infected asymptomatic persons is an unanswered question. Despite advances in both automation and point-of-care diagnostics, we continue to rely on indirect measures of disease activity to manage this infection. As syphilis rates in some populations continue to rise, novel and effective prevention strategies are needed.

show abstract

The Impact of Combined Antiretroviral Therapy on Biologic False-Positive Rapid Plasma Reagin Serologies in a Longitudinal Cohort of HIV-Infected Persons

Abstract: The use of cART appears to decrease the odds of BFP RPR tests. This finding suggests that nontreponemal titer fluctuations in persons with HIV may reflect the influence of factors unrelated to syphilis disease activity.

Cited by 17 publications

References 19 publications

Use of the palm Euterpe edulismartius in landscape units managed by migrants of German origin in Southern Brazil

Use of the palm Euterpe edulismartius in landscape units managed by migrants of German origin in Southern Brazil

Serological Response to Treatment of Syphilis with Doxycycline Compared with Penicillin in HIV-Infected Individuals

Emerging trends and persistent challenges in the management of adult syphilis

Contact Info

Product

Resources

About