Demographic characteristics and health-related quality of life of patients with moderate-to-severe psoriasis: The VACAP study

Abstract

The principal factor related to HRQoL in patients with psoriasis is the severity of the disease.

Health-related quality of life in patients with psoriasis: a systematic review of the European literature

“…Confirming these results, disease activity determined using a visual analog scale showed a correlation with the DLQI and the PASI [31]. Several studies confirmed the finding that improvements in HRQoL were linked to the enhancements of clinical manifestations of the disease [19,22,32], and identified disease severity (assessed by the PASI) as a predictor of HRQoL [21][22][23][24][25] (Table 4). In line with these results, the determinants of HRQoL measured by the DLQI indicated that a one-unit increase in PASI from the mean would increase the DLQI score by 0.29 (p = 0.002) [33].…”

“…In this sense, the effect of stigmatization on HRQoL was driven by a combination of symptom severity and stigmatization, suggesting that the effects of the latter on HRQoL were strongly associated with the emotional component of HRQoL [18]. Conversely, optimism correlated negatively with the overall score on the Skindex-29, thus indicating that the stronger the optimism is, the better the HRQoL will be [22,24].…”

“…Thus, although some studies indicated that the severity of psoriasis was significantly higher in men than in women [13], they did not perceive the severity of the symptoms of psoriasis differently [18], but they did, however, present differences in discomfort levels [18] and HRQoL [13,18,19]. Linear regression analysis showed that females were more affected than men in all dimensions of the SF-36 [20][21][22]. Gender differences were concentrated on emotional and psychological aspects of experiencing psoriasis, and results revealed that women perceived a greater impact of psoriasis on mental health [18].…”

“…Thus, patients with PASI [ 10 and/or DLQI [ 10 before switching experienced the greatest benefit in HRQoL [13]. [19] HRQoL PsoA versus PsoE: Daudén et al [22] Linear regression analysis: Disease severity was one of the most significant factors in determining HRQoL: b = 0.405 p \ 0.001 Miniszewska et al [23] Regression analysis: The more sever skin condition (PASI) the worse HRQoL: b = 0.25 p = 0.001…”

“…43.36(SD:11.89) versus Women = 38.03(SD:11.50)Daudén et al[22] Multivariate linear regression analysis: gender was one of the most significant factors determining HRQoL: b = 0.075; p = 0.048Norlin et al[13] Median (IQR) EQ-5D score (p \ 0.0001):Men= 0.796 (IQR: 0.725-1) versus Women = 0.76 (IQR: 0.656-0.848) Median (IQR) DLQI score (p \ 0.0033): Men = 4 (IQR: 1-8) versus Women = 5 (IQR: 1-11) Lindberg et al [20] Linear regression analysis: females were more affected than men in all dimension of SF-36: r(PF) = -4.46; p \ 0.0001, r(RP) = -4.27; p \ 0.0001, r(BP) = -5.58; p \ 0.0001, r(GH) = -2.39; p \ 0.0002, r(VT) = -5.69; p \ 0.0001, r(SF) = -4.20; p \ 0.0001, r(RE) = -3.75; p \ 0.0001, r(MH) = -3.66; p \ 0.0001 Miniszewska et al [23] In terms of HRQoL and optimism, gender does not differentiate respondents: t = -0.08; p = 0.75 Miniszewska et al [24] Mean (SD) Skindex-29 score: Men = 89.1(SD:24.1) versus Women = 84.9(SD:23.3); p = nonsignificant Blome et al [21] Regression model: being female was a relevant factor predicting impaired HRQoL: b = 0.62; p = 0.041 HRQoL and age Miniszewska et al [23] Age correlates positively with all domains and overall score of Skindex (HRQoL): t = 3.35; p \ 0.01 Miniszewska et al [24] Mean (SD) DLQI score: (\ 40 years) = 78.1 (SD:21.36) versus ([ 40 years) = 93.1 (SD:23.9); p \ 0.001 Fernandez-Torres et al [25] Mean (SD) DLQI score: Young patients (\ 65 years) = 5.49(SD:6) versus older patients ([ 65 years) = 3.89(SD:5.03); p = 0.012 Hernánz et al [26] Regression model: The increase on age is associated with better HRQoL: OR 0.973, CI 95 % = 0.957-0.989 Blome et al [21] Regression model: The increase on age is associated with better HRQoL: b = -0.04; p = 0.001 Cozzani et al [27] Neither DLQI nor PsoriQoL correlated significantly with age: DLQI: r = 0.337; p = 0.068 PsoriQoL: r = 0.328; p = 0.947…”