Reduction in screening for retinopathy of prematurity through risk factor adjusted inclusion criteria

Sorge, Arlette J. van; Schalij‐Delfos, Nicoline E.; Kerkhoff, F T; Rijn, L.J. van; Hillegersberg, J L A M van; Liempt, I L A van; Peer, Petronella G. M.; Simonsz, Huibert J.; Termote, J.

doi:10.1136/bjophthalmol-2013-303123

Cited by 42 publications

(39 citation statements)

References 21 publications

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“…13;17–24 These models varied as they use different predictors for different severity of ROP (RW-ROP, severe ROP, treatment requiring ROP, etc.). In contrast to previous ROP prediction models/algorithms, our prediction model and resulting risk score is unique in that we used the findings of trained readers’ evaluation of images taken at the first image session (34 PMA weeks or earlier) for predicting the future development of TR-ROP.…”

Section: Discussionmentioning

confidence: 99%

Risk Score for Predicting Treatment-Requiring Retinopathy of Prematurity (ROP) in the Telemedicine Approaches to Evaluating Acute-Phase ROP Study

et al. 2016

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Purpose To develop a risk score for predicting treatment-requiring ROP (TR-ROP) as determined by study-certified ophthalmologists in the e-ROP study. Design Second Analyses of an observational cohort study. Participants Infants with birth weight <1251g who had at least one imaging session by 34 weeks of postmenstrual age (PMA) and at least one subsequent ROP examination for determining TR-ROP by study-certified ophthalmologists. Methods Non-physician trained readers evaluated wide-field retinal image sets for characteristics of ROP, pre-plus/plus disease and retinal hemorrhage. Risk score points for predicting TR-ROP were derived from the regression coefficients of significant predictors in a multivariate logistic regression model. Results Among 771 infants, 85 (11.0%) developed TR-ROP. In a multivariate model, significant predictors [odds ratio (95% confidence interval)] for TR-ROP were: gestational age (GA) [5.7 (1.7 – 18.9) for ≤25 vs. ≥28 weeks], need for respiratory support [7.0 (1.3 – 37.1) for high frequency oscillatory ventilation vs. no respiratory support], slow weight gain [2.4 (1.2 – 4.6) for weight gain ≤12g/day vs. >15g/day], and image findings at the first image session including: number of quadrants with pre-plus [3.8 (1.5 – 9.7) for 4 pre-plus quadrants vs. no pre-plus], stage and zone of ROP [4.7 (2.1 – 11.8) for stage 1–2 zone I, 5.9 (2.1 – 16.6) for stage 3 zone I vs. no ROP], and presence of blot hemorrhage [3.1 (1.4 – 6.7)]. Image findings predicted TR-ROP better than GA (area under ROC curve [AUC] =0.82 vs. 0.75, p=0.03). The 22-point risk score derived from 6 significant predictors had a median of 4 points (range: 0 to 18). The risk of TR-ROP steadily increased with higher risk score (0% for 0 point, 1–8% for 1–5 points, 12–27% for 6–10 points, 43% for 11–13 points and 94% for 14 points or above), and predicted TR-ROP well (AUC=0.88, 95% CI: 0.85–0.92). Risk score ≥3 points for predicting TR-ROP had sensitivity 98.8%, specificity 40.1%, positive and negative predictive values of 17.0% and 99.6% respectively. Conclusions Image characteristics at 34 PMA weeks or earlier independently predict TR-ROP. If externally validated in other infants, risk score, calculated from image findings, GA, weight gain and respiratory support, enables early identification of infants in need of increased surveillance for TR-ROP.

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Section: Discussionmentioning

confidence: 99%

Risk Score for Predicting Treatment-Requiring Retinopathy of Prematurity (ROP) in the Telemedicine Approaches to Evaluating Acute-Phase ROP Study

et al. 2016

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“…As the numbers of infants with ELBW and VLBW who survive increase, more will need screening for ROP. Detection and treatment of ROP are important to prevent poor vision in these infants,5 so that they will have a better quality of life. However, severe ROP may result in blindness or poor sight even with treatment.…”

Section: Discussionmentioning

confidence: 99%

“…In the last decade, the incidence of overall and severe ROP has decreased significantly in developed countries 5. Studies conducted in high-income countries suggest that severe ROP is mainly detected in infants born at <28 weeks’ gestational age (GA); in addition, most infants born at >30 weeks’ GA have no or mild ROP.…”

Section: Introductionmentioning

confidence: 99%

Incidence and severity of retinopathy of prematurity in Turkey

2015

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“…The alternative is a national inventory on a regular basis. The NEDROP study resulted in a new guideline25 for screening and treatment of ROP. Oral communication at regional and national meetings, quality indicators and an online e-learning should second all-encompassing implementation, the results of which will be evaluated in the next national inventory.…”

Section: Discussionmentioning

confidence: 99%

Outcome and quality of screening in a nationwide survey on retinopathy of prematurity in The Netherlands

et al. 2014

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Reduction in screening for retinopathy of prematurity through risk factor adjusted inclusion criteria

Cited by 42 publications

References 21 publications

Risk Score for Predicting Treatment-Requiring Retinopathy of Prematurity (ROP) in the Telemedicine Approaches to Evaluating Acute-Phase ROP Study

Risk Score for Predicting Treatment-Requiring Retinopathy of Prematurity (ROP) in the Telemedicine Approaches to Evaluating Acute-Phase ROP Study

Incidence and severity of retinopathy of prematurity in Turkey

Outcome and quality of screening in a nationwide survey on retinopathy of prematurity in The Netherlands

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