Association Study of MICA-TM Polymorphism with Inflammatory Bowel Disease in the South Tunisian Population

Kamoun, A; Bouzid, Dorra; Mahfoudh, N.; Amouri, A.; Gaddour, Lilia; Hakim, Faiza; Tahri, N.; Masmoudi, Hatem; Makni, H.

doi:10.1089/gtmb.2012.0423

Cited by 6 publications

(5 citation statements)

References 39 publications

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“…The association of MICA*A5.1 with UC has been described [33,46] in the Chinese population, whereas no association was found by other authors [35,36]. The association of MICA*A5.1 with EIMs [7,33,39] and its relation with the location of disease [38] was also described. In our study, no differences were found with regard to location of disease and, although no differences were found after correction for multiple comparisons, the frequency of MICA*A5.1 homozygous genotype is higher in patients with EIMs: half of UC patients with the MICA*A5.1/A5.1 genotype suffered some EIMs, while the frequency of EIMs in patients with other genotypes was 33%.…”

Section: Discussionmentioning

confidence: 94%

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MICAA4 protects against ulcerative colitis, whereas MICAA5.1 is associated with abscess formation and age of onset

Martínez-Chamorro

Moreno

Gómez‐García

et al. 2016

Clinical and Experimental Immunology

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SummaryUlcerative colitis (UC) is one of the two major forms of inflammatory bowel disease, the aetiology of which remains unknown. Several studies have demonstrated the genetic basis of disease, identifying more than 130 susceptibility loci. The major histocompatibility complex class I chainrelated gene A (MICA) is a useful candidate to be involved in UC pathogenesis, because it could be important in recognizing the integrity of the epithelial cell and its response to stress. The aim of this study was to analyse the relationship between polymorphisms in the transmembrane domain of MICA and susceptibility to develop UC. A total of 340 patients with UC and 636 healthy controls were genotyped for MICA transmembrane polymorphism using a polymerase chain reaction (PCR) combined with fluorescent technology. Different MICA alleles were determined depending on the PCR product size. The allele MICA*A4 was less frequent in patients than in controls (P 5 0Á003; OR 5 0Á643), and this protective role is higher when it forms haplotype with B*27 (P 5 0Á002; OR 5 0Á294). The haplotype HLA-B*52/MICA*A6 was also associated with UC [P 5 0Á001; odds ratio (OR) 5 2Á914]. No other alleles, genotypes or haplotypes were related with UC risk. Moreover, MICA*A5.1 is associated independently with abscesses (P 5 0Á002; OR 5 3Á096) and its frequency is lower in patients diagnosed between ages 17 and 40 years (P 5 0Á007; OR 5 0Á633), meaning an extreme age on onset. No association with location, extra-intestinal manifestations or need for surgery was found.

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Section: Discussionmentioning

confidence: 94%

“…Moreover, MICA-STR alleles have been associated with UC phenotype, as location of disease [32,38], age at onset [32,39] or extraintestinal manifestations (EIMs) [7,33,39]. Kamoun et al [39] suggested the association of MICA with CD, but in many studies there was no evidence of this association [7,[35][36][37].…”

Section: Introductionmentioning

confidence: 99%

MICAA4 protects against ulcerative colitis, whereas MICAA5.1 is associated with abscess formation and age of onset

Martínez-Chamorro

Moreno

Gómez‐García

et al. 2016

Clinical and Experimental Immunology

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“…MICA-A5.1 was identified as a protective allele to CD and extensive form of UC in two independent case-control studies including Tunisian (36 cases/123 controls) and Spanish (121/116) cohorts, respectively [ 81 , 82 ]. On the other hand, MICA-A5 was correlated with worse progression of UC [ 82 ], and was associated with late age of onset of CD [ 81 ]. MICA-A6 also was associated with UC in Tunish and Japanese (case/control: 36/12 and 83/132, respectively) studies [ 81 , 83 ].…”

Section: Mica In Rheumatic Disease Associated Inflammatory Bowel Disementioning

confidence: 99%

“…On the other hand, MICA-A5 was correlated with worse progression of UC [ 82 ], and was associated with late age of onset of CD [ 81 ]. MICA-A6 also was associated with UC in Tunish and Japanese (case/control: 36/12 and 83/132, respectively) studies [ 81 , 83 ]. A higher frequency of MICA-129met/met was reported in IBD patients of Murcians (case/control: 88/154) [ 84 ].…”

Section: Mica In Rheumatic Disease Associated Inflammatory Bowel Disementioning

confidence: 99%

Associations of MICA Polymorphisms with Inflammatory Rheumatic Diseases

Wang¹,

Zhou

2015

TORJ

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Inflammatory rheumatic diseases are characterized by inflammation resulting from the immune dysregulation that usually attacks joints, skin and internal organs. Many of them are considered as complex disease that may be predisposed by multiple genes and/or genetic loci, and triggered by environmental factors such as microbiome and cellular stress. The major histocompatibility complex class I chain-related gene A (MICA) is a highly polymorphic gene that encodes protein variants expressed under cellular stress conditions, and these MICA variants play important roles in immune activation and surveillance. Recently, accumulating evidences from both genetic and functional studies have suggested that MICA polymorphisms may be associated with various rheumatic diseases, and the expression of MICA variants may attribute to the altered immune responses in the diseases. The objective of this review is to discuss potential genetic associations and pathological relevance of MICA in inflammatory rheumatic diseases that may help us to understand pathogenesis contributing to the development of these diseases.

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“…The etiology and pathogenesis of IBDs have not been fully elucidated. According to reports in the literature, they may be associated with genetics [ 3 ], environment [ 4 ], microbiota [ 5 ], and intestinal immune dysfunction [ 6 ]. At the beginning of the 20 th century, there were millions of people suffering from IBDs.…”

Section: Introductionmentioning

confidence: 99%

Kangfuxin Liquid Ameliorates Dextran Sulfate Sodium (DSS)-Induced Acute Ulcerative Colitis in Mice by Modulating Immune Response and Suppressing Inflammation

Tang

et al. 2021

Med Sci Monit Basic Res

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Background The aim of this study was to determine the effect of kangfuxin liquid (KFXL) on inflammatory response, and its underlying mechanism in treating acute ulcerative colitis (UC) in mice induced by dextran sulfate sodium (DSS). Material/Methods Mice were provided drinking water containing DSS (3%) for 7 days to induce acute enteritis. The mice were divided into 6 groups: a control group, a DSS-induced (vehicle) group, a sulfasalazine (SASP) group, and low-, medium-, and high-dose kangfuxin liquid groups. Disease activity index (DAI), colon mucosa damage index (CMDI), histopathological score (HS), and organ index were monitored daily. The levels of interleukin-1β (IL-1β), interleukin-10 (IL-10) in serum and interleukin-17 (IL-17) and epidermal growth factor (EGF) in colon tissue were assessed by enzyme-linked immunosorbent assay (ELISA). Flow cytometry was used to assess the changes of T lymphocyte subsets in spleens of mice to evaluate the therapeutic effect of drugs on acute UC in mice. Results Different doses of kangfuxin liquid reduced the DAI, CMDI, and HS scores ( P <0.01 or P <0.05) of acute UC mice, reduced the level of IL-1β and IL-17 in serum, increased the expression of IL-10 in serum and EGF in colon tissue, increased the number of CD3 + T cells, and decreased the level of CD4 + T cells and the ratio of CD4 + /CD8 + . Conclusions Kangfuxin liquid has a therapeutic effect on DSS-induced acute UC in mice, and its mechanism of action may be associated with regulating immune function and reducing intestinal inflammatory response.

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Association Study of MICA-TM Polymorphism with Inflammatory Bowel Disease in the South Tunisian Population

Abstract: Some clinical features of CD and UC may be influenced by specific MICA-TM alleles. In our South Tunisian population, MICA plays a disease modifying role, rather than being an important gene in the susceptibility for developing IBD.

Cited by 6 publications

References 39 publications

MICAA4 protects against ulcerative colitis, whereas MICAA5.1 is associated with abscess formation and age of onset

MICAA4 protects against ulcerative colitis, whereas MICAA5.1 is associated with abscess formation and age of onset

Associations of MICA Polymorphisms with Inflammatory Rheumatic Diseases

Kangfuxin Liquid Ameliorates Dextran Sulfate Sodium (DSS)-Induced Acute Ulcerative Colitis in Mice by Modulating Immune Response and Suppressing Inflammation

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Association Study of MICA-TM Polymorphism with Inflammatory Bowel Disease in the South Tunisian Population

Abstract: Some clinical features of CD and UC may be influenced by specific MICA-TM alleles. In our South Tunisian population, MICA plays a disease modifying role, rather than being an important gene in the susceptibility for developing IBD.

Cited by 6 publications

References 39 publications

MICA*A4 protects against ulcerative colitis, whereas MICA*A5.1 is associated with abscess formation and age of onset

MICA*A4 protects against ulcerative colitis, whereas MICA*A5.1 is associated with abscess formation and age of onset

Associations of MICA Polymorphisms with Inflammatory Rheumatic Diseases

Kangfuxin Liquid Ameliorates Dextran Sulfate Sodium (DSS)-Induced Acute Ulcerative Colitis in Mice by Modulating Immune Response and Suppressing Inflammation

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MICAA4 protects against ulcerative colitis, whereas MICAA5.1 is associated with abscess formation and age of onset

MICAA4 protects against ulcerative colitis, whereas MICAA5.1 is associated with abscess formation and age of onset