Association of Total Marine Fatty Acids, Eicosapentaenoic and Docosahexaenoic Acids, With Aortic Stiffness in Koreans, Whites, and Japanese Americans

Shin, Chol; Barinas‐Mitchell, Emma; Hirooka, Nobutaka; Willcox, Bradley J.; Choo, Jina; White, Jessica; Evans, Rhobert W.; Fujiyoshi, Akira; Okamura, Tomonori; Miura, Katsuyuki; Muldoon, Matthew F.; Ueshima, Hirotsugu; Kuller, Lewis H.; Sutton-Tyrrell, Kim

doi:10.1093/ajh/hpt107

Cited by 11 publications

(7 citation statements)

References 35 publications

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“…In a trial evaluating patients with cardiovascular risk factors a fish oil diet was ineffective in reducing brachial-ankle pulse wave velocity, while the subsequent administration of pure EPA in the same population significantly reduced the arterial stiffness [ 61 ]. Considering cross-sectional studies, in general Japanese population, there was no relationship between serum omega-3 levels and arterial stiffness, evaluated as brachial-ankle PWV [ 62 ], while in a sample of 299 Korean men a regression analysis found a significant inverse association with total n-3 PUFA and carotid-femoral PWV [ 63 ].…”

Section: N-3 Pufa and Arterial Stiffness: In Vivo Studiesmentioning

confidence: 99%

Omega-3 Polyunsaturated Fatty Acids: Structural and Functional Effects on the Vascular Wall

Zanetti

Grillo

Losurdo

et al. 2015

BioMed Research International

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Omega-3 polyunsaturated fatty acids (n-3 PUFA) consumption is associated with reduced cardiovascular disease risk. Increasing evidence demonstrating a beneficial effect of n-3 PUFA on arterial wall properties is progressively emerging. We reviewed the recent available evidence for the cardiovascular effects of n-3 PUFA focusing on structural and functional properties of the vascular wall. In experimental studies and clinical trials n-3 PUFA have shown the ability to improve arterial hemodynamics by reducing arterial stiffness, thus explaining some of its cardioprotective properties. Recent studies suggest beneficial effects of n-3 PUFA on endothelial activation, which are likely to improve vascular function. Several molecular, cellular, and physiological pathways influenced by n-3 PUFA can affect arterial wall properties and therefore interfere with the atherosclerotic process. Although the relative weight of different physiological and molecular mechanisms and the dose-response on arterial wall properties have yet to be determined, n-3 PUFA have the potential to beneficially impact arterial wall remodeling and cardiovascular outcomes by targeting arterial wall stiffening and endothelial dysfunction.

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Section: N-3 Pufa and Arterial Stiffness: In Vivo Studiesmentioning

confidence: 99%

Omega-3 Polyunsaturated Fatty Acids: Structural and Functional Effects on the Vascular Wall

Zanetti

Grillo

Losurdo

et al. 2015

BioMed Research International

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“…The HealthTrack study used AUSNUT 2007, the most recent food composition database available at the beginning of the study; however AUSNUT 2007 only reports total LCn3PUFA rather than EPA and DHA separately. This may limit comparisons with LCn3PUFA studies in the literature . Measurement of baPWV and ABI did not follow standard operational procedures published by the American Heart Association for vascular research, and the device used to measure baPWV and ABI was only standardised for the Japanese population .…”

Section: Discussionmentioning

confidence: 99%

Relationship between long‐chain omega‐3 polyunsaturated fatty acid intake and ankle brachial index, pulse wave velocity and resting heart rate in a sample of overweight adults: A secondary analysis of baseline data in the HealthTrack study

Senevirathne

Neale

Peoples

et al. 2018

Nutrition & Dietetics

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Aim: The present study aimed to explore the association between dietary long-chain omega-3 polyunsaturated fatty acid (LCn3PUFA) intake and cardiovascular risk indicators (ankle brachial index, resting heart rate and brachial-ankle pulse wave velocity) in a clinical sample of overweight and obese participants volunteering for a weight loss trial. Methods: This was a secondary analysis of baseline data from the HealthTrack study (n = 351). LCn3PUFA intake was calculated via a diet history and the association with ankle brachial index, resting heart rate and brachio-ankle pulse wave velocity was explored using linear regression after controlling for covariates. Results: LCn3PUFA intake was inversely associated with ankle brachial index (R 2 change = 0.021, F change (1, 339) = 8.864, P < 0.05) and resting heart rate (R 2 change = 0.014, F change (1, 342) = 5.337, P < 0.05) but not with brachio-ankle pulse wave velocity (R 2 change = 0.001, F change (1, 339) = 0.725, P > 0.05). Conclusions: In this clinical sample of overweight adults, LCn3PUFA consumption was significantly associated with a lower resting heart rate, adding to the current evidence on the potential benefits of LCn3PUFA consumption. It also supports the value of targeting a diet rich in this nutrient when planning future dietetic approaches. Relationships with ankle brachial index and pulse wave velocity require further investigation. Future research should assess the effect of changes in dietary LCn3PUFA intake on novel cardiovascular risk indicators.Key words: ankle brachial index, cardiovascular risk factors, diet history, LCn3PUFA, pulse wave velocity, resting heart rate. motes endothelial damage and increases back-pressure to the left ventricle of the heart, causing left ventricular hypertrophy and coronary ischaemia, ultimately resulting in CVD. 17,18 Improving arterial stiffness (i.e. reducing PWV) aids CVD prevention and treatment in clinical practice. 19,20 PAD is the blockage or narrowing of medium to small arteries supplying limbs, mainly the lower extremities, and is primarily diagnosed by ankle brachial index (ABI) in clinical practice. The main cause of PAD is atherosclerosis. [21][22][23][24] Coexisting severe coronary atherosclerosis and similar A. Senevirathne, MBBS, MNutr&Diet,

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“…A cross-sectional study on Japanese women indicated that the PWV of the aorta was significantly slower in fishing villages than in the farming villages where people usually eat less fish [ 42 ]. The serum levels of total marine omega-3 PUFAs, EPA, and DHA were higher in the Korean middle-aged men than in the Caucasians and Japanese American counterparts, and that total marine omega-3 PUFAs had a significant inverse association with carotid-femoral PWV in Korean men only [ 43 ]. Among the Japanese patients with a CVD risk factor, a fish-based diet (> 1.0 g/d omega-3 PUFAs derived from fish) was effective against increased baPWV only in the patients with a low CVD risk [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Association between fish and shellfish, and omega-3 PUFAs intake and CVD risk factors in middle-aged female patients with type 2 diabetes

et al. 2015

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BACKGROUND/OBJECTIVESThis study was performed to investigate the association between the dietary intake of fish and shellfish, and omega-3 polyunsaturated fatty acids (PUFAs) and cardiovascular disease (CVD) risk factors in the middle-aged Korean female patients with Type 2 diabetes (T2D).SUBJECTS/METHODSA cross-sectional analysis was performed with 356 female patients (means age: 55.5 years), who were recruited from the Huh's Diabetes Clinic in Seoul, Korea between 2005 and 2011. The dietary intake was assessed by a validated semi-quantitative food frequency questionnaire and analyzed using the Computer Aided Nutritional Analysis program (CAN-Pro) version 4.0 software.RESULTSIn a multiple regression analysis after the adjustment for confounding factors such as age, BMI, duration of diagnosed T2D, alcohol consumption, fiber intake, sodium intake, and total energy intake, fish and shellfish intake of the subjects was negatively associated with triglyceride and pulse wave velocity (PWV). Omega-3 PUFAs intake was negatively associated with triglyceride, systolic blood pressures, diastolic blood pressures, and PWV. The multiple logistic regression analysis with the covariates showed a significant inverse relationship between the omega-3 PUFAs consumption and prevalence of hypertriglyceridemia [OR (95% CI) for greater than the median compared to less than the median: 0.395 (0.207-0.753)].CONCLUSIONSThese results suggest that the consumption of fish and shellfish, good sources of omega-3 PUFAs, may reduce the risk factors for CVD in the middle-aged female patients with T2D.

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Association of Total Marine Fatty Acids, Eicosapentaenoic and Docosahexaenoic Acids, With Aortic Stiffness in Koreans, Whites, and Japanese Americans

Abstract: High levels of EPA observed in Koreans have an inverse association with aortic stiffness.

Cited by 11 publications

References 35 publications

Omega-3 Polyunsaturated Fatty Acids: Structural and Functional Effects on the Vascular Wall

Omega-3 Polyunsaturated Fatty Acids: Structural and Functional Effects on the Vascular Wall

Relationship between long‐chain omega‐3 polyunsaturated fatty acid intake and ankle brachial index, pulse wave velocity and resting heart rate in a sample of overweight adults: A secondary analysis of baseline data in the HealthTrack study

Association between fish and shellfish, and omega-3 PUFAs intake and CVD risk factors in middle-aged female patients with type 2 diabetes

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