Screening for Type 2 Diabetes in a High-Risk Population: Effects of a Negative Screening Test After 4 Years Follow-up

Willems, Julie I.; Otto, Suzie J.; Klijs, Bart; Koning, Harry J. de

doi:10.1007/s12160-013-9525-3

Cited by 7 publications

(12 citation statements)

References 51 publications

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“…Our findings suggest that perceived risk is not associated with actual risk including BMI, physical activity, diet, and history of gestational diabetes. This echoes the findings of studies of women with a history of gestational diabetes mellitus including American women and Dutch people [11,31,34] [35]. Perhaps our participants’ lack of knowledge on the risks associated with T2DM and time to focus on their own health explains this finding.…”

Section: Discussionsupporting

confidence: 81%

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The risk, perceived and actual, of developing type 2 diabetes mellitus for mothers of preschool children in urban China

Guo

Tang

Zhang³

et al. 2019

PLoS ONE

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BackgroundThe perceived risk of developing type 2 diabetes mellitus (T2DM) can motivate individuals to adopt preventive health behaviors. Compared with fathers, mothers of young children often experience unique risk factors for developing T2DM: pregnancy-related weight gain, lifestyle changes related to child care, and the increased incidence of gestational diabetes mellitus. Understanding how actual risk factors affect the perceived risk of developing T2DM can foster effective diabetes prevention interventions for this population. The aims of this study were to describe the risk, perceived and actual, of developing T2DM and to explore the influencing factors of perceived risk for Chinese mothers of preschool children in China.MethodsA multisite, cross-sectional survey was conducted and included 176 mothers (mean age of 31.19 years old) of preschool children (aged 3–7 years old) from four preschools in Changsha, the capital city of Hunan Province, China. The overall perceived risk of developing T2DM was measured by one item “Your own personal health risk is at almost no risk, slight risk, moderate risk or high risk from diabetes” from the Risk Perception Survey for Developing Diabetes (RPS-DD). PRS-DD and the Chinese version of the Canadian Diabetes Risk Assessment Questionnaire (CHINARISK) were used to assess perceived risk related worry, personal control, optimistic bias, and diabetes risk knowledge and actual risk of T2DM. Mothers also reported their height, weight, and waist circumference followed by the NIH protocol. Pearson correlation and stepwise multivariate linear regression were used to explore how the actual risk factors affected the perceived risk of developing diabetes (RPS-DD)).ResultsNearly 90% of mothers perceived almost no/slight risk for developing diabetes. Nearly half of the mothers had parents or siblings with diabetes. Roughly 70% of the mothers did not eat five servings of fruits and vegetables per day, and more than 50% did not exercise at least 30 minutes a day. In the five stepwise multivariate linear regression models, young mothers (95% CI .400–1.311) and those with a family history of diabetes (95% CI -0.74- .000) were founded a higher overall perceived risk. Mothers who reported more sedentary time (95% CI -0.029- -0.008) and less physical activity had less personal control (95% CI -0.354- -0.046). Mothers with more sedentary time had more worries about developing T2DM(95% CI 0.008–0.035) . Mothers who were older (95% CI -0.440–0.055) or had more physical activities (95% CI 0.003–0.048) had more optimistic bias of not developing T2DM. Mothers who had a higher education level (95% CI .354–1.422) and a family history of diabetes (95% CI .029–2.231) had more diabetes risk knowledge of developing T2DM.ConclusionThis study found that Chinese mothers of preschool children in urban areas reported low perceived risk of developing T2DM, although they have actual risk factors. These women did not associate anthropometric, health history, or health behavior factors with the risk of developing T...

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Section: Discussionsupporting

confidence: 81%

“…Future studies are needed to prospectively explore the relationship between perceived risk of developing T2DM and lifestyle behaviors. [34].…”

Section: Discussionmentioning

confidence: 99%

The risk, perceived and actual, of developing type 2 diabetes mellitus for mothers of preschool children in urban China

Guo

Tang

Zhang³

et al. 2019

PLoS ONE

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“…In another study, negative screening tests did not falsely reassure individuals at high risk for developing diabetes, whose intentions for behavioral change were essentially the same for negative results recipients and the control group [ 20 ]. A complementary study showed that four years after follow-up, screening negative for diabetes did not lead to long-term changes in lifestyle [ 21 ]. Though there are limitations as to the extent of parallels that can be drawn between these studies and genomic screening, these studies are examples of settings that may provide insights into the communication of a negative genomic screening results that may aid future research.…”

Section: Discussionmentioning

confidence: 99%

Neutral, Negative, or Negligible? Changes in Patient Perceptions of Disease Risk Following Receipt of a Negative Genomic Screening Result

Stuttgen

Pacyna

Kullo

2020

JPM

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Most individuals who undergo genomic screening will receive negative results or results not sufficient to warrant a clinical response. Even though a majority of individuals receive negative results, little is known about how negative results may impact individuals’ perception of disease risk. Changes in risk perception (specifically reductions in perceived risk) may affect both probands and their family members if inaccurate information is communicated to family members. We surveyed patients who received negative results as part of their participation in a genomic screening study and assessed their perceptions of disease risk following receipt of results. Participants had either hyperlipidemia or colon polyps (or both) and received their negative genomic screening results by mail. Of 1712 total individuals recruited, 1442 completed the survey (84.2% completion rate). Approximately one quarter of individuals believed their risk for heart disease to be lower and approximately one third of individuals believed their risk for colon cancer to be lower after receiving and evaluating their negative genomic screening result. 78% of those who believed their risk for one or both diseases had declined had already shared or intended to share their result with family members. Our study suggests patients may interpret a negative genomic screening result as implying a reduction in their overall disease risk.

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“…A previous study by Paddison et al has shown that a negative screening result does not lower participants’ intentions to reduce dietary fat and sugar intake and to increase physical activity after first appointment or at 3–6 months or 12–15 months [23]. Willems et al found that neither a negative screening test for diabetes nor non-invitation to a screening test made any difference to overt changes towards a healthier lifestyle at 4 years follow-up [24]. Our study found that screening for diabetes brought long-term positive lifestyle change in both -in the pre-diabetes and normoglycaemia groups equally.…”

Section: Discussionmentioning

confidence: 99%

Impact of a diabetes screening program on a rural Chinese population: a 3-year follow-up study

et al. 2015

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BackgroundScreening for type 2 diabetes helps detect previously unknown diabetes and identify people with pre-diabetes, but the adverse impact of such screening on individuals labelled as pre-diabetes or classified as normal, is less known. In this study the health-related quality of life (HRQoL), depression and lifestyle changes in a rural Chinese population are assessed three years after a screening program.MethodsA total of 647 (39.1%) individuals with pre-diabetes and 1009 (60.9%) individuals with normoglycaemia from a population-based diabetes screening program in 2009 were re-examined in 2012–2013. Changes at the end of 3 years in HRQoL, depression, BMI, weight, frequency of physical activity and vegetable intake were assessed.ResultsIn men with normoglycaemia the mean (SD) 15D scores were 0.974 (0.04) at baseline and 0.973 (0.05) at follow-up; and 0.971 (0.05) and 0.966 (0.06) for men with pre-diabetes. In women the scores were 0.973 (0.05) and 0.963 (0.06) for normoglycaemia and 0.959 (0.06) and 0.954 (0.07) for pre-diabetes, respectively. Compared to baseline, the HRQoL was slightly lower at 3 years in all groups but the change was not considered to be clinically important, and was only statistically significant for women with normoglycaemia (p < 0.05). The depression score was slightly elevated in women, but not in men. No significant changes in BMI were noticed, but weight increased slightly in the normoglycemia group (p < 0.05). Screening had a significant positive impact on physical activity and vegetable intake.ConclusionsThis population-based diabetes screening program generated long-term positive changes toward a healthy lifestyle as measured by physical activity and vegetable intake for all the participants without adverse effects on the HRQoL and depression.

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Screening for Type 2 Diabetes in a High-Risk Population: Effects of a Negative Screening Test After 4 Years Follow-up

Abstract: Screening negative for diabetes did not lead to overt long-term changes in lifestyle, despite a high perception of risk of developing diabetes. (ISRCTN75983009.).

Cited by 7 publications

References 51 publications

The risk, perceived and actual, of developing type 2 diabetes mellitus for mothers of preschool children in urban China

The risk, perceived and actual, of developing type 2 diabetes mellitus for mothers of preschool children in urban China

Neutral, Negative, or Negligible? Changes in Patient Perceptions of Disease Risk Following Receipt of a Negative Genomic Screening Result

Impact of a diabetes screening program on a rural Chinese population: a 3-year follow-up study

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