Concomitant autoantibodies in newly diagnosed diabetic children with transient celiac serology or proven celiac disease

Hojsak, Iva; Zevit, Noam; Waisbourd‐Zinman, Orith; Rosenbach, Yoram; Mozer‐Glassberg, Yael; Shalitin, Shlomit; Phillip, Moshe; Shamir, Raanan

doi:10.1515/jpem-2013-0035

Cited by 6 publications

(4 citation statements)

References 10 publications

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“…The frequency of GAD65 and IA-2 autoantibodies in CD [10,13,24] and ATD [11] has previously been reported. However, to date, the ZnT8 anti-islet autoimmune status in young patients with ATD and/or CD has not been described.…”

Section: Discussionmentioning

confidence: 99%

Anti-Zinc Transporter Protein 8 Antibody Testing Is Not Informative in Routine Prediabetes Screening in Young Patients with Autoimmune Thyroiditis and Celiac Disease

et al. 2016

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Background/Aims: Patients with type 1 diabetes mellitus (T1DM), autoimmune thyroiditis (ATD), and celiac disease (CD) are at increased risk for developing other autoimmune diseases. We evaluated zinc transporter 8 (ZnT8) prevalence in patients with ATD and/or CD in order to define the usefulness of ZnT8 autoantibodies for prediabetes screening. Methods: Eighty-one young patients with ATD and/or CD were included in the study; 32 subjects with clinical onset of T1DM were enrolled as a control group. GAD65, IA-2, and ZnT8 antibodies were measured. An intravenous glucose tolerance test, C-peptide, glycosylated hemoglobin levels, and genomic analysis of HLA-DQA1* and -DQB1* were also considered in patients positive for autoantibodies. Results: The ZnT8 prevalence was higher in T1DM patients than in patients with other autoimmune diseases (p < 0.001); positive ZnT8 detection was found in 2 ATD (p = 0.004) and 3 ATD + CD (p = 0.04) patients. Positive ZnT8 was associated with GAD65 (p = 0.01) but not with IA-2 positivity. No correlation between ZnT8 detection and the number of T1DM-susceptible HLA-DQ heterodimers was found. Pathological C-peptide levels and insulin response were found in subjects with islet autoimmunity and genetic susceptibility. Conclusion: ZnT8 autoantibodies detection in ATD and/or CD patients is low, and routine ZnT8 screening is not justified. ZnT8 evaluation may be recommended in subjects with autoimmune diseases as a marker for predicting compromised insulin secretion.

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Section: Discussionmentioning

confidence: 99%

Anti-Zinc Transporter Protein 8 Antibody Testing Is Not Informative in Routine Prediabetes Screening in Young Patients with Autoimmune Thyroiditis and Celiac Disease

et al. 2016

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“…Transient positivity of anti TG2 ABs. Several groups reported on the natural longitudinal variation of serum levels of TG2 ABs in diabetic or genetic high risk CD young children or adolescents [35,36,37].…”

Section: True False Positive Iga-anti Human Tg2 Absmentioning

confidence: 99%

Outside of Normal Limits: False Positive/Negative Anti TG2 Autoantibodies

Lerner¹,

Jeremias²,

Tenbusch³

2016

IJCD

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Detection of IgA-transglutaminase2 (TG2) autoantibodies has become the test of choice for the diagnosis and monitoring of celiac disease (CD), and is recommended as the serological 'gold standard' by most of the CD societies. Despite its wide acceptance and reasonable performance, several aspects are problematic and disputed. The normal range levels between positivity and negativity are modified, manufacturers' cut-off levels are extremely variable, far from matching in house determinations, insufficient standardization, inadequate reference protocols and no reliable quality assessment of the ELISA antibody (AB) kits for CD diagnosis and follow-up of dietary adherence. Numerous limitations exist in its detection, diagnosis, and follow-up capacities, resulting in frequent clinical circumstances when professionals encounter false positive and negative situations. The present review updates and discusses these facets and aims to extend our knowledge and help CD associated professionals to use the IgA-TG2 antibodies appropriately. We hope that the content of the review will stimulate the scientific community to explore and better delineate the role and functions of the AB and the industrial manufacturers to improve clinical performance of their diagnostic tests.

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“…The question arises as to whether the CD or thyroid specific AB would have disappeared in steroid-free situations. It is well known, at least in celiac associated AB, that even on GCD, the autoantibodies might fluctuate, attaining normal levels periodically [4,5].…”

Section: The Boy Did Not Have CDmentioning

confidence: 99%

Transient Anti TG2 Autoantibodies in Systemic Lupus Erythematosus: A Window to Autoimmunity

Lerner¹,

Prager²,

Tenbusch³

2016

IJCD

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Transient anti transglutaminase2 and anti endomysial antibody elevation in systemic lupus erythematosus is fundamentally thought-provoking with respect to establishment of autoimmunity and its progression. Celiac disease and systemic lupus erythematosus are both relayed within the mosaic framework of autoimmunity. Transglutaminase2 is a multifunctional enzyme, involved in cell biology and survival and is one of the post translational modifiers of protein, enhancing autoimmunity. TG2 and its specific antibodies are heavily involved in celiac disease. TG2 is essential in clearance of apoptotic cells and experimentally participates in systemic lupus-like induction. However, the role of anti TG2 autoantibodies is far from being unraveled. Despite disappearance of these antibodies on gluten containing diet, in the present case, the boy is at risk of developing celiac disease in the future.

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Concomitant autoantibodies in newly diagnosed diabetic children with transient celiac serology or proven celiac disease

Abstract: Neither the number of concomitant autoantibodies nor their titers in newly diagnosed T1DM differed between patients with proven CD and those with transient TTG serology.

Cited by 6 publications

References 10 publications

Anti-Zinc Transporter Protein 8 Antibody Testing Is Not Informative in Routine Prediabetes Screening in Young Patients with Autoimmune Thyroiditis and Celiac Disease

Anti-Zinc Transporter Protein 8 Antibody Testing Is Not Informative in Routine Prediabetes Screening in Young Patients with Autoimmune Thyroiditis and Celiac Disease

Outside of Normal Limits: False Positive/Negative Anti TG2 Autoantibodies

Transient Anti TG2 Autoantibodies in Systemic Lupus Erythematosus: A Window to Autoimmunity

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