New long circulating magnetoliposomes as contrast agents for detection of ischemia–reperfusion injuries by MRI

Martins, M.B.F.; Corvo, M. Luísa; Marcelino, Paulo; Marinho, H. Susana; Feio, Gabriel; Carvalho, A.

doi:10.1016/j.nano.2013.06.008

Cited by 23 publications

(21 citation statements)

References 36 publications

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“…As shown in figure 7 and figure 8, both melanoma cell lines (B164A5 and A375 cells) manifested no altered morphological aspects after treatment with the lowest [25]. Beside hyperthermia and drug controlled release, recent studies reported the efficacy of magnetoliposomes as contrast agents: in a rat model of liver ischemia-reperfusion [26] or in a diabetic rat model for labeling pancreatic islets [27].…”

Section: Cell Morphology After Treatment With Test Samplesmentioning

confidence: 99%

Preliminary Results of Betulinic Acid-Loaded Magnetoliposomes - a Potential Approach to Increase Therapeutic Efficacy in Melanoma

Farcaş¹,

Moacă²,

Drăgoi³

et al. 2019

Rev. Chim.

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Magnetoliposomes were placed into the biomedical spotlight due to their unique structure, preserving also magnetic features valuable for biomedical applications. The present study provides a preliminary evidence of the cytotoxicity induced by betulinic acid-loaded magnetoliposomes (BA-Fe3O4@Lip) on two melanoma cell lines - A375 and B164A5 cells and one healthy cell line - mice epidermis JB6 Cl 41-5a cells, augmented by references to potential biomedical applications. BA-Fe3O4@Lip showed significant cytotoxicity on the melanoma cell lines, compared with the blank liposomal structures. In addition, the healthy cell line displayed good viability rate after exposure to BA-Fe3O4@Lip.

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Section: Cell Morphology After Treatment With Test Samplesmentioning

confidence: 99%

Preliminary Results of Betulinic Acid-Loaded Magnetoliposomes - a Potential Approach to Increase Therapeutic Efficacy in Melanoma

Farcaş¹,

Moacă²,

Drăgoi³

et al. 2019

Rev. Chim.

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“… 3 – 5 In this context, superparamagnetic iron oxide nanoparticles (SPIONs) are frequently incorporated in liposomes and the resultant magnetoliposomes are used as theranostic vehicles. 6 In this concise review, two different magnetoliposomes 7 – 10 will be reviewed for their capacity to enhance contrast in MRI. Their ability to act as negative contrast agents (CA), that is, to mainly shorten the transverse relaxation time and in one of the cases their efficiency to detect liver ischemia-reperfusion injuries (IRI), 8 will be discussed in a comparative approach.…”

Section: Introductionmentioning

confidence: 99%

“… 6 In this concise review, two different magnetoliposomes 7 – 10 will be reviewed for their capacity to enhance contrast in MRI. Their ability to act as negative contrast agents (CA), that is, to mainly shorten the transverse relaxation time and in one of the cases their efficiency to detect liver ischemia-reperfusion injuries (IRI), 8 will be discussed in a comparative approach.…”

Section: Introductionmentioning

confidence: 99%

Development of New Contrast Agents for Imaging Function and Metabolism by Magnetic Resonance Imaging

Carvalho¹,

Gonçalves

Corvo

et al. 2017

Magn Reson�Insights

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Liposomes are interesting nanosystems with a wide range of medical application. One particular application is their ability to enhance contrast in magnetic resonance images; when properly loaded with magnetic/superparamagnetic nanoparticles, this means to act as contrast agents. The design of liposomes loaded with magnetic particles, magnetoliposomes, presents a large number of possibilities depending on the application from image function to metabolism. More interesting is its double function application as theranostics (diagnostics and therapy). The synthesis, characterization, and possible medical applications of two types of magnetoliposomes are reviewed. Their performance will be compared, in particular, their efficiency as contrast agents for magnetic resonance imaging, measured by their relaxivities r1 and r2 relating to their particular composition. One of the magnetoliposomes had 1,2-diacyl-sn-glycero-3-phosphocholine (soy) as the main phospholipid component, with and without cholesterol, varying its phospholipid to cholesterol molar ratios. The other formulation is a long-circulating liposome composed of 1,2-diacyl-sn-glycero-3-phosphocholine (egg), cholesterol, and 1,2-distearoyl-sn-glycerol-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]. Both nanosystems were loaded with superparamagnetic iron oxide nanoparticles with different sizes and coatings.

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“…The low risk to patients makes it an appropriate and increasingly popular tool for clinical diagnosis. 1 Because of the relatively low sensitivity of MRI for tumor diagnosis, contrast agents (CAs) are used to improve the quality of MR images, thereby improving the diagnostic accuracy. These agents consist of molecules incorporating a paramagnetic metal ion.…”

Section: Introductionmentioning

confidence: 99%

In vitro study of novel gadolinium-loaded liposomes guided by GBI-10 aptamer for promising tumor targeting and tumor diagnosis by magnetic resonance imaging

Gu¹,

Li²,

Zhang³

et al. 2015

IJN

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Novel gadolinium-loaded liposomes guided by GBI-10 aptamer were developed and evaluated in vitro to enhance magnetic resonance imaging (MRI) diagnosis of tumor. Nontargeted gadolinium-loaded liposomes were achieved by incorporating amphipathic material, Gd (III) [ N , N -bis-stearylamidomethyl- N ′-amidomethyl] diethylenetriamine tetraacetic acid, into the liposome membrane using lipid film hydration method. GBI-10, as the targeting ligand, was then conjugated onto the liposome surface to get GBI-10-targeted gadolinium-loaded liposomes (GTLs). Both nontargeted gadolinium-loaded liposomes and GTLs displayed good dispersion stability, optimal size, and zeta potential for tumor targeting, as well as favorable imaging properties with enhanced relaxivity compared with a commercial MRI contrast agent (CA), gadopentetate dimeglumine. The use of GBI-10 aptamer in this liposomal system was intended to result in increased accumulation of gadolinium at the periphery of C6 glioma cells, where the targeting extracellular matrix protein tenascin-C is overexpressed. Increased cellular binding of GTLs to C6 cells was confirmed by confocal microscopy, flow cytometry, and MRI, demonstrating the promise of this novel delivery system as a carrier of MRI contrast agent for the diagnosis of tumor. These studies provide a new strategy furthering the development of nanomedicine for both diagnosis and therapy of tumor.

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New long circulating magnetoliposomes as contrast agents for detection of ischemia–reperfusion injuries by MRI

Cited by 23 publications

References 36 publications

Preliminary Results of Betulinic Acid-Loaded Magnetoliposomes - a Potential Approach to Increase Therapeutic Efficacy in Melanoma

Preliminary Results of Betulinic Acid-Loaded Magnetoliposomes - a Potential Approach to Increase Therapeutic Efficacy in Melanoma

Development of New Contrast Agents for Imaging Function and Metabolism by Magnetic Resonance Imaging

In vitro study of novel gadolinium-loaded liposomes guided by GBI-10 aptamer for promising tumor targeting and tumor diagnosis by magnetic resonance imaging

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New long circulating magnetoliposomes as contrast agents for detection of ischemia–reperfusion injuries by MRI

Cited by 23 publications

References 36 publications

Preliminary Results of Betulinic Acid-Loaded Magnetoliposomes - a Potential Approach to Increase Therapeutic Efficacy in Melanoma

Preliminary Results of Betulinic Acid-Loaded Magnetoliposomes - a Potential Approach to Increase Therapeutic Efficacy in Melanoma

Development of New Contrast Agents for Imaging Function and Metabolism by Magnetic Resonance Imaging

In vitro study of novel gadolinium-loaded liposomes guided by GBI-10 aptamer for promising tumor targeting and tumor diagnosis by&nbsp;magnetic resonance imaging

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In vitro study of novel gadolinium-loaded liposomes guided by GBI-10 aptamer for promising tumor targeting and tumor diagnosis by magnetic resonance imaging