Clinical Research in Surgical Oncology: An Analysis of ClinicalTrials.gov

Abstract

The number of registered surgical oncology trials is small in comparison to oncology trials as a whole. Clinical trials specifically designed to assess surgical interventions are vastly outnumbered by trials focusing on adjuvant therapies. Randomized surgical oncology trials account for <1% of all registered cancer trials. Barriers to the design and implementation of randomized trials in surgical oncology need to be clarified in order to facilitate higher-level evidence in surgical decision-making.

Clinical research activity in periodontal medicine: a systematic mapping of trial registers

“…This was consistent with other fields of biomedical research, such as surgical oncology, where 15% of registration records in ClinicalTrials.gov were observational studies (Menezes et al. ).…”

“…Although we analysed data from trial registers, we found a substantial proportion of the registered trials to be observational studies (16%). This was consistent with other fields of biomedical research, such as surgical oncology, where 15% of registration records in Clini-calTrials.gov were observational studies (Menezes et al 2013).…”

Analysis of Registered Clinical Trials in Surgical Oncology, 2008-2020

“…Surgical interventions are essential in the treatment of solid organ tumors, yet surgical interventions are infrequently studied via clinical trials. 1 , 2 This study characterizes surgical oncology trials registered on ClinicalTrials.gov, analyzes growth, identifies associations with early discontinuation or results reporting, and evaluates proportions of trials involving each neoplasm site.…”

Registered Interventional Clinical Trials for Old Populations With Infectious Diseases on ClinicalTrials.gov: A Cross-Sectional Study

“…Several studies provided comprehensive details about registered trials in several fields ( Pasquali et al., 2012 ; Menezes et al., 2013 ; Hill et al., 2014 ; Chen et al., 2018 ); however, there is paucity of published works on the subject of intervention of infectious diseases in old populations. ( Califf et al., 2012 ) provides publicly accessible data of registered clinical trials, affords the most comprehensive source for identifying and tracking completed or ongoing trials, and is the best way to explore the characteristics of registered trials in particular fields ( Pasquali et al., 2012 ; Menezes et al., 2013 ; Hill et al., 2014 ; Chen et al., 2018 ). Thus, we performed the current cross-sectional study to investigate the characteristic of registered trials regarding intervention against infectious diseases in old populations.…”