Dislipidemia aterogénica en pacientes con diabetes mellitus tipo 1

Chillarón, Josep; Sales, Maria Penha Uchoa; Le-Roux, Juana A. Flores; Castells, Ignasi; Benaiges, David; Sagarra, Enric Ballesteros i; Pedro‐Botet, Juan

doi:10.1016/j.medcli.2013.03.016

Cited by 6 publications

(3 citation statements)

References 25 publications

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“…As for hypertriglyceridemia, its prevalence in T1D patients ranges from 13 to 31% [48]. Patients with higher triglyceride levels have a two to three times higher risk of all microangiopathic complications, and this risk is evident even at a young age and without a long duration of diabetes [49].…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular Risk Factors in Children and Adolescents with Type 1 Diabetes Mellitus: The Role of Insulin Resistance and Associated Genetic Variants

Maguolo¹,

Rioda²,

Zusi³

et al. 2022

Horm Res Paediatr

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Introduction: Type 1 diabetes (T1D) is associated with increased risk of cardiovascular disease. Insulin resistance is an important cardiovascular risk factor (CVRF), also in subjects with T1D, but the influence of the genetic predisposition of insulin resistance on cardiovascular risk is still unknown in T1D. We aimed to determine whether a genetic score composed of six variants, previously associated to insulin resistance and type 2 diabetes (T2D) risk, associates with insulin sensitivity and known CVRFs in children and adolescents with T1D. Materials and Methods: 330 children and adolescents (174 males; mean age 15.7±3.5 years) with T1D were genotyped for the following genetic variants: rs1801278 (IRS1), rs1044498 (ENPP1), rs2295490 (TRIB3), rs1801282 (PPARG), rs780094 (GCKR), and rs35767 (IGF1). An additive genetic risk score (GRS) and cardiovascular risk score (CVRS) were calculated. Anthropometric, glycemic control, insulin sensitivity, blood pressure, and biochemical parameters were assessed. Multivariate regression between evaluated phenotypes and GRS were performed. Results: We found a significant association between the GRS and estimated insulin sensitivity [β=-0.027 (-0.040 to -0.013), R2=0.86, p=<0.001], diastolic blood pressure [β=0.68 (0.08-1.27), R2=0.20, p=0.026], triglycerides [β=4.26 (1.74-6.77), R2=0.13, p=0.001], waist to height ratio [β=0.003 (0.001-0.006), R2=0.75, p=0.010], non-HDL-cholesterol [β=3.63 (1.39-5.87), R2=0.12, p=0.002], and CVRS [β=0.063 (0.008-0.118), R2=0.19, p=0.025], independent of age, sex, BMI, pubertal stage, diabetes duration, HbA1c, type of treatment and total insulin requirement. The addition of the GRS to established clinical risk factors significantly improved the discriminatory capability of the regression model for predicting subjects with more CVRFs (C-statistic 0.89 [95%CI 0.84–0.95] vs. 0.83 [0.73–0.93]; p = 0.037). Conclusions: Insulin resistance and T2D risk-associated genetic variants influence insulin sensitivity and known cardiovascular risk factors in children and adolescents with T1D.

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Section: Discussionmentioning

confidence: 99%

Cardiovascular Risk Factors in Children and Adolescents with Type 1 Diabetes Mellitus: The Role of Insulin Resistance and Associated Genetic Variants

Maguolo¹,

Rioda²,

Zusi³

et al. 2022

Horm Res Paediatr

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“…En personas con diabetes debemos siempre pensar en una posible dislipemia aterogénica que incluye alteraciones tanto cuantitativas como cualitativas de los lípidos sanguíneos: valores de triglicéridos aumentados, bajo nivel de c-HDL y predominancia de partículas de c-LDL pequeñas y densas, claramente más aterogénicas, no solo por su tamaño y facilidad para atravesar el endotelio vascular, sino, además, por su particular susceptibilidad a sufrir modificaciones oxidativas. Todo ello supone un riesgo residual elevado lo que condiciona la presencia de aterosclerosis acelerada y mayor riesgo de infarto de miocardio y de accidente cerebrovascular 12 .…”

Section: Otros Planteamientosunclassified

Oportunidades para abordar del riesgo cardiometabólico residual del paciente con DM2 en Atención Primaria

Navarro

Miguel²,

Ortega

et al. 2021

Contexto_epidemiologico

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“…La actividad de la LPL en la DM2 es objeto de controversia. Si bien la insulina es clave para la sínte-sis celular y translocación de LPL hacia el endotelio y los pacientes con DM tipo 1 presentan déficit de LPL, no existen evidencias de una menor expresión de la LPL en la DM2, aunque sí disminuye su actividad 10 .…”

Section: Elevación De Los Triglicéridosunclassified

Recomendaciones de buena práctica en el tratamiento de la dislipemia en la diabetes

Pozo¹,

Mancera-Romero

Pérez-Unanua

et al. 2015

SEMERGEN - Medicina de Familia

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Dislipidemia aterogénica en pacientes con diabetes mellitus tipo 1

Cited by 6 publications

References 25 publications

Cardiovascular Risk Factors in Children and Adolescents with Type 1 Diabetes Mellitus: The Role of Insulin Resistance and Associated Genetic Variants

Cardiovascular Risk Factors in Children and Adolescents with Type 1 Diabetes Mellitus: The Role of Insulin Resistance and Associated Genetic Variants

Oportunidades para abordar del riesgo cardiometabólico residual del paciente con DM2 en Atención Primaria

Recomendaciones de buena práctica en el tratamiento de la dislipemia en la diabetes

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