AGT M235T polymorphisms and ischemic stroke risk: A meta-analysis

Liang, Baoyun; Qin, Liuqun; Wei, Huijun; Yan, Yan; Su, Li; Wu, Guangliang; Tan, Jinjing; Gu, Lian

doi:10.1016/j.jns.2013.05.034

Cited by 18 publications

(7 citation statements)

References 20 publications

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“…One previous meta-analysis indicated that the M235T polymorphism is associated with ischemic stroke risk in Asians, but not in Caucasians. 11 However, that meta-analysis included only a few limited papers that covered individuals of Chinese ancestry. Most of the relevant studies performed in Chinese participants were published in Chinese in local journals.…”

Section: Introductionmentioning

confidence: 99%

Association of polymorphisms in the AGT gene(M235T, T174M) with ischemic stroke in the Chinese population

Gao

Huang

et al. 2015

J Renin Angiotensin Aldosterone Syst

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Section: Introductionmentioning

confidence: 99%

Association of polymorphisms in the AGT gene(M235T, T174M) with ischemic stroke in the Chinese population

Gao

Huang

et al. 2015

J Renin Angiotensin Aldosterone Syst

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“…[ 21 ] In addition, the M235T polymorphism was in strong linkage disequilibrium with the T174M polymorphism. [ 22 ] A recent meta-analysis showed that the AGT M235T polymorphism was a risk factor for IS among Asians,[ 23 ] the linkage disequilibrium of M235T and T174M in exon 2 of the AGT gene may synergistically increase the risk of IS.…”

Section: Discussionmentioning

confidence: 99%

Association between angiotensinogen T174M polymorphism and ischemic stroke: A meta-analysis

Chen

Liu

et al. 2015

J Res Med Sci

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Background:Numerous studies have evaluated the association between the angiotensinogen (AGT) T174M polymorphism and ischemic stroke(IS) risk. However, the specific association is still controversial.Materials and Methods:In order to explore this association more deeply, we performed a meta-analysis. All of the relevant studies were identified from PubMed, Embase, and Chinese National Knowledge Infrastructure database up to October 2014. Statistical analyses were conducted with STATA 12.0 software. Odds ratio (OR) with 95% confidence interval (CI) values were applied to evaluate the strength of the association.Results:Six studies with 1290 cases and 1125 controls were included. No significant variation in IS risk was detected in any of the genetic models in the overall (MM vs. TT: OR = 1.64, 95% CI = 0.51-5.28; MT vs. TT: OR = 0.93, 95% CI = 0.66-1.31; dominant model: OR = 1.08, 95% CI = 0.69-1.72; recessive model: OR = 0.61,95% CI = 0.20-1.91). Taking into account the effect of ethnicity, further stratified analyses were performed. The results showed that AGT gene T174M polymorphism might be associated with IS risk in Asians (MM vs. TT: OR = 3.28, 95% CI = 1.79-6.02; recessive model: OR = 0.31, 95% CI = 0.17-0.57).Conclusion:In conclusion, the AGT T174M polymorphism may be a susceptible predictor of the risk of IS in Asians. Further, large and well-designed studies are needed to confirm this conclusion.

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“…В связи с этим можно предположить, что носители аллельного варианта 174M имеют повышенную концентрацию АГТ и, соответ-ственно, высокую активность РААС, которая патогенети-чески может быть связана с развитием МИ [15]. Таким образом, полиморфный вариант T174M гена AGT -один из генетических модуляторов активности РААС, а АГТ, участвуя в регуляции АД, может быть напрямую вовлечен в патогенез МИ [33]. Отметим, что нами обнаружены четкие половые раз-личия ассоциации полиморфного маркера T174M с ри-ском развития МИ.…”

Section: та стецкая и соавтunclassified

Association of Т174М polymorphism of the angiotensinogen gene with the higher risk of cerebral stroke in women

Стецкая¹,

Бушуева²,

Булгакова³

et al. 2014

Ter. arkh.

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AGT M235T polymorphisms and ischemic stroke risk: A meta-analysis

Cited by 18 publications

References 20 publications

Association of polymorphisms in the AGT gene(M235T, T174M) with ischemic stroke in the Chinese population

Association of polymorphisms in the AGT gene(M235T, T174M) with ischemic stroke in the Chinese population

Association between angiotensinogen T174M polymorphism and ischemic stroke: A meta-analysis

Association of Т174М polymorphism of the angiotensinogen gene with the higher risk of cerebral stroke in women

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