Lymphatic invasion predicts survival in patients with early node-negative non–small cell lung cancer

Abstract

Lymphatic invasion represents an independent risk factor for node-negative NSCLC. Its implications on therapy decision making should be further evaluated, especially in early stages.

Correlation Between Expression of Cell Adhesion Molecules CD44v6 and E-cadherin and Lymphatic Metastasis in Non-small Cell Lung Cancer

“…Surgery is the optimal therapy for early NSCLC, whereas the major factor that affects surgery results is presence or absence of lymphatic metastasis. Additionally, as the primary metastatic pathway in lung cancer, lymphatic metastasis is also the principal factor that affects the radical resection and prognosis in NSCLC Nentwich et al, 2013).…”

Prognostic Significance of Clinical/Pathological Stage IA Non-Small-Cell Lung Cancer Showing Partially Solid or Solid Tumours on Radiological Exam

“…18) Other studies have also demonstrated that lung adenocarcinoma manifests as partially solid nodules, with a greater proportion of GGO lesions and less invasive lung cancer types. [6][7][8][9][10][11][12][13][14] Our adaptation of limited surgery included tumours of ≤20 mm under lung window conditions, those of <5 mm under TSCT mediastinum window conditions and for those with negative PET uptake and/or CEA levels of ≤5.0 ng/mL. 19) In the present study, 17 of 138 (12.3%) patients underwent segmentectomy and lymph node dissection.…”

“…[6][7][8][9][10][11][12][13][14] Accordingly, clinical trials of reductive surgery for various small lung cancers have been performed. Several studies have indicated that limited resection is an appropriate surgical procedure for non-solid nodules observed on HRCT and the majority of these nodules were pathologically shown to be adenocarcinoma in situ.…”

“…In pT1abN0M0 lung cancers, tumour size is not the only measure of malignancy, as tumour shadow disappearance rate (TDR), 2) visual estimation of the consolidation component, 2,3) solid component size, 4) maximum standardised uptake values (SUVmax) from 18F-fluorodeoxyglucose positron emission tomography (PET)/CT, 5) ratio of the size of solid attenuation to the maximum tumour dimensions (consolidation/tumour [C/T] ratio), 6,7) lymphatic invasion, 8) proportion of ground-glass opacity (GGO) 9) and tumour necrosis 10) have also been reported as prognostic factors.…”

Prognostic potential of the MDM2 309T>G polymorphism in stage I lung adenocarcinoma

“…The precise mechanism underlying the worse OS with the T/T genotype being associated with p53 status remains unknown [32]. However, tumors of MDM2 T/T patients tended to be positive in LVI and pleural invasion (Table 3), which have been reported to be worse prognostic factors associated with tumor proliferation and aggressiveness [33,34]. These results indicate that the tumors of T/T patients in the stage I period might have overall malignant potential, although p53 tumor suppressor function is normal.…”