Porcine Islet Adaptation to Metabolic Need of Monkeys in Pig-to-Monkey Intraportal Islet Xenotransplantation

Lee, J.-I.; Shin, Jong Son; Jung, Wooyoung; Lee, G.; Kim, M.-S.; Kim, Y.-S.; Choi, Jee Woong; Park, Chung Gyu; Kim, S.-J.

doi:10.1016/j.transproceed.2013.01.090

Cited by 9 publications

(5 citation statements)

References 9 publications

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“…While porcine islet xenotransplantation is still in its experimental stages, centers all over the world have reported successful reversal of hyperglycemia in non‐human primate recipients and some have even commenced trials in human patients . Valdes‐Gonzalez et al.…”

Section: Discussionmentioning

confidence: 99%

Impact of donor age and weaning status on pancreatic exocrine and endocrine tissue maturation in pigs

Krishnan

Truong

Gerges

et al. 2015

Xenotransplantation

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Section: Discussionmentioning

confidence: 99%

Impact of donor age and weaning status on pancreatic exocrine and endocrine tissue maturation in pigs

Krishnan

Truong

Gerges

et al. 2015

Xenotransplantation

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“…Graft function was confirmed as the cause for normoglycemia, as all 32 mice reverted back to hyperglycemia after islet graft removal [36]. Many studies using NHP models have demonstrated the benefits of the pig islets as xenotransplants, with a potential cure for diabetes [25,39,[98][99][100][101]. These studies have shown diabetes reversal with prolonged graft survival in diabetic NHPs.…”

Section: In Vitro and In Vivo Assessment Of Pig Islet Functionmentioning

confidence: 99%

Porcine Islet Cell Xenotransplantation

Chinnuswami¹,

Hussain²,

Loganathan³

et al. 2020

Xenotransplantation - Comprehensive Study

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This article reviews the rationale, sources and preparation of pig islets for xenotransplantation. Pancreatic islet cell transplantation is an attractive alternative and an effective treatment option for type 1 diabetes, however, donor pancreas shortages prevent islet transplantation from being a widespread solution as the supply cannot possibly equal the demand. Porcine islet xenotransplantation has the potential to address these shortages, and recent preclinical and clinical trials show promising scientific support. Pig islets provide a readily available source for islet transplantation, with the recent trials in non-human primates (NHPs) demonstrating their potential to reverse diabetes. The risk of zoonosis can be reduced by designated pathogen-free breeding of the donor pigs, but porcine endogenous retroviruses (PERVs) which are integrated into the genome of all pigs, are especially difficult to eliminate. However, clinical trials have demonstrated an absence of PERV transmission with a significant reduction in the number of severe hypoglycemic episodes and up to 30% reduction in exogenous insulin doses. A number of methods are currently being tested to overcome the xenograft immune rejection. Some of these methods include the production of various transgenic pigs to better xenotransplantation efficiency and the encapsulation of islets to isolate them from the host immune system. Furthermore, ongoing research is also shedding light on factors such as the age and breed of the donor pig to determine the optimal islet quantity and function.

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“…This has been observed for pig xenotransplantation cell therapy products where the much higher need for insulin in macaques (than in humans or pigs) creates an imbalance between the metabolic demand and the pig islet product; this situation is model-specific and is not anticipated in the clinical condition (Casu et al, 2008;Graham et al, 2011a;Graham and Schuurman, 2013;Wijkstrom et al, 2013). Dosing adaptations may be one way to successfully compensate this effect in short-term preclinical studies: this adaptation obviously lacks translational value (Lee et al, 2013a).…”

Section: Species Differences In T1d Modelsmentioning

confidence: 99%

Validity of animal models of type 1 diabetes, and strategies to enhance their utility in translational research

Graham

Schuurman²

2015

European Journal of Pharmacology

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Porcine Islet Adaptation to Metabolic Need of Monkeys in Pig-to-Monkey Intraportal Islet Xenotransplantation

Cited by 9 publications

References 9 publications

Impact of donor age and weaning status on pancreatic exocrine and endocrine tissue maturation in pigs

Impact of donor age and weaning status on pancreatic exocrine and endocrine tissue maturation in pigs

Porcine Islet Cell Xenotransplantation

Validity of animal models of type 1 diabetes, and strategies to enhance their utility in translational research

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