Impaired learning of predators and lower prey survival under elevated <scp><scp>CO<sub>2</sub></scp></scp>: a consequence of neurotransmitter interference

Chivers, Douglas P.; McCormick, Mark I.; Nilsson, Göran; Munday, Philip L.; Watson, Sue‐Ann; Meekan, Mark G.; Mitchell, Matthew D.; Corkill, Katherine; Ferrari, Maud C. O.

doi:10.1111/gcb.12291

Cited by 181 publications

(172 citation statements)

References 48 publications

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“…Gabazine also significantly alters the behaviour of control rockfish and pink salmon (Ou et al, 2015). However, no other study found any effect of gabazine on behaviour (Chivers et al, 2014;Lai et al, 2015;Lopes et al, 2016;Munday et al, 2016;Nilsson et al, 2012;Watson et al, 2014) or visual processing (Chung et al, 2014) in control fish. This is an interesting point because gabazine should also affect normal inhibitory GABA regulation, inducing neuronal excitation; in fact, one of the features precluding the use of gabazine as a therapeutic agent in humans is the risk of convulsions resulting from inappropriate neuronal excitation (Enna and Bowery, 1997).…”

Section: Pharmacological Considerationsmentioning

confidence: 88%

Acid–base physiology, neurobiology and behaviour in relation to CO2-induced ocean acidification

Tresguerres

Hamilton

2017

Journal of Experimental Biology

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Experimental exposure to ocean and freshwater acidification affects the behaviour of multiple aquatic organisms in laboratory tests. One proposed cause involves an imbalance in plasma chloride and bicarbonate ion concentrations as a result of acid-base regulation, causing the reversal of ionic fluxes through GABA A receptors, which leads to altered neuronal function. This model is exclusively based on differential effects of the GABA A receptor antagonist gabazine on control animals and those exposed to elevated CO 2 . However, direct measurements of actual chloride and bicarbonate concentrations in neurons and their extracellular fluids and of GABA A receptor properties in aquatic organisms are largely lacking. Similarly, very little is known about potential compensatory mechanisms, and about alternative mechanisms that might lead to ocean acidificationinduced behavioural changes. This article reviews the current knowledge on acid-base physiology, neurobiology, pharmacology and behaviour in relation to marine CO 2 -induced acidification, and identifies important topics for future research that will help us to understand the potential effects of predicted levels of aquatic acidification on organisms.

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Section: Pharmacological Considerationsmentioning

confidence: 88%

Acid–base physiology, neurobiology and behaviour in relation to CO2-induced ocean acidification

Tresguerres

Hamilton

2017

Journal of Experimental Biology

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“…Gabazine and muscimol were applied to Ctl 1 and OA 1 groups on days 9 and 10, respectively. Gabazine is a specific GABA A -receptor antagonist [34] that has become a popular tool to study the effects of OA on fish behaviour [8,14]. Muscimol is a specific agonist of GABA A receptors [35], including fish GABA A receptors [36 -38].…”

Section: (B) Drug Administrationmentioning

confidence: 99%

CO₂-induced ocean acidification increases anxiety in Rockfish via alteration of GABA_Areceptor functioning

2014

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The average surface pH of the ocean is dropping at a rapid rate due to the dissolution of anthropogenic CO 2 , raising concerns for marine life. Additionally, some coastal areas periodically experience upwelling of CO 2 -enriched water with reduced pH. Previous research has demonstrated ocean acidification (OA)-induced changes in behavioural and sensory systems including olfaction, which is due to altered function of neural gamma-aminobutyric acid type A (GABA A ) receptors. Here, we used a camera-based tracking software system to examine whether OA-dependent changes in GABA A receptors affect anxiety in juvenile Californian rockfish (Sebastes diploproa). Anxiety was estimated using behavioural tests that measure light/dark preference (scototaxis) and proximity to an object. After one week in OA conditions projected for the next century in the California shore (1125 + 100 matm, pH 7.75), anxiety was significantly increased relative to controls (483 + 40 matm CO 2 , pH 8.1). The GABA A -receptor agonist muscimol, but not the antagonist gabazine, caused a significant increase in anxiety consistent with altered Cl 2 flux in OA-exposed fish. OA-exposed fish remained more anxious even after 7 days back in control seawater; however, they resumed their normal behaviour by day 12. These results show that OA could severely alter rockfish behaviour; however, this effect is reversible.

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“…In addition to elevated sea surface temperature (SST), a growing body of literature has focused on the impacts ocean acidification will have on marine teleosts; however, the majority of these studies have focused primarily on tropical or temperate species (Melzner et al, 2009;Munday et al, 2009a;Munday et al, 2009b;Munday et al, 2010;Munday et al, 2011;Esbaugh et al, 2012;Heuer et al, 2012;Nowicki et al, 2012;Bignami et al, 2013;Chivers et al, 2014;Munday et al, 2014;Murray et al, 2014;Pope et al, 2014). Despite projections that indicate changes in SST and partial pressure of CO 2 (Ṗ CO2 ) in seawater will impact higher latitudes faster and to a greater Is warmer better?…”

Section: Introductionmentioning

confidence: 99%

Is warmer better? Decreased oxidative damage in notothenioid fish after long-term acclimation to multiple stressors

Enzor

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2014

Journal of Experimental Biology

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Antarctic fish of the suborder Notothenioidei have evolved several unique adaptations to deal with subzero temperatures. However, these adaptations may come with physiological trade-offs, such as an increased susceptibility to oxidative damage. As such, the expected environmental perturbations brought on by global climate change have the potential to significantly increase the level of oxidative stress and cellular damage in these endemic fish. Previous single stressor studies of the notothenioids have shown they possess the capacity to acclimate to increased temperatures, but the cellularlevel effects remain largely unknown. Additionally, there is little information on the ability of Antarctic fish to respond to ecologically relevant environmental changes where multiple variables change concomitantly. We have examined the potential synergistic effects that increased temperature and Ṗ CO2 have on the level of protein damage in Trematomus bernacchii, Pagothenia borchgrevinki and Trematomus newnesi, and combined these measurements with changes in total enzymatic activity of catalase (CAT) and superoxide dismutase (SOD) in order to gauge tissue-specific changes in antioxidant capacity. Our findings indicate that total SOD and CAT activity levels displayed only small changes across treatments and tissues. Short-term acclimation to decreased seawater pH and increased temperature resulted in significant increases in oxidative damage. Surprisingly, despite no significant change in antioxidant capacity, cellular damage returned to near-basal levels, and significantly decreased in T. bernacchii, after long-term acclimation. Overall, these data suggest that notothenioid fish currently maintain the antioxidant capacity necessary to offset predicted future ocean conditions, but it remains unclear whether this capacity comes with physiological trade-offs.

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Impaired learning of predators and lower prey survival under elevated CO₂: a consequence of neurotransmitter interference

Cited by 181 publications

References 48 publications

Acid–base physiology, neurobiology and behaviour in relation to CO2-induced ocean acidification

Acid–base physiology, neurobiology and behaviour in relation to CO2-induced ocean acidification

CO₂-induced ocean acidification increases anxiety in Rockfish via alteration of GABA_Areceptor functioning

Is warmer better? Decreased oxidative damage in notothenioid fish after long-term acclimation to multiple stressors

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Impaired learning of predators and lower prey survival under elevated CO2: a consequence of neurotransmitter interference

Cited by 181 publications

References 48 publications

Acid–base physiology, neurobiology and behaviour in relation to CO2-induced ocean acidification

Acid–base physiology, neurobiology and behaviour in relation to CO2-induced ocean acidification

CO2-induced ocean acidification increases anxiety in Rockfish via alteration of GABAAreceptor functioning

Is warmer better? Decreased oxidative damage in notothenioid fish after long-term acclimation to multiple stressors

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Impaired learning of predators and lower prey survival under elevated CO₂: a consequence of neurotransmitter interference

CO₂-induced ocean acidification increases anxiety in Rockfish via alteration of GABA_Areceptor functioning