Structural profiling and biological performance of phospholipid–hyaluronan functionalized single-walled carbon nanotubes

Dvash, Ram; Khatchatouriants, Artium; Solmesky, Leonardo J.; Wibroe, Peter P.; Weil, Miguel; Moghimi, S. Moein; Peer, Dan

doi:10.1016/j.jconrel.2013.05.042

Cited by 26 publications

(18 citation statements)

References 45 publications

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“…Due to the probable latency, follow-up analysis should be performed on CNT-exposed people. It should be noted that preliminary reports suggest that functionalisation allowing CNT solubilisation and enhancing their biocompatibility using water-soluble nanoconjugates seems to be emerging as a safe and effective procedure, with no cytotoxicity on macrophages and epithelial cells [169,170]. In conclusion, these observations have the following relevant implications.…”

Section: Potential Mechanisms Of Cnt Oncogenesismentioning

confidence: 77%

Malignant pleural mesothelioma: history, controversy and future of a manmade epidemic

2015

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Asbestos is the term for a family of naturally occurring minerals that have been used on a small scale since ancient times. Industrialisation demanded increased mining and refining in the 20th century, and in 1960, Wagner, Sleggs and Marchand from South Africa linked asbestos to mesothelioma, paving the way to the current knowledge of the aetiology, epidemiology and biology of malignant pleural mesothelioma. Pleural mesothelioma is one of the most lethal cancers, with increasing incidence worldwide. This review will give some snapshots of the history of pleural mesothelioma discovery, and the body of epidemiological and biological research, including some of the controversies and unresolved questions. Translational research is currently unravelling novel circulating biomarkers for earlier diagnosis and novel treatment targets. Current breakthrough discoveries of clinically promising noninvasive biomarkers, such as the 13-protein signature, microRNAs and the BAP1 mesothelioma/cancer syndrome, are highlighted. The asbestos history is a lesson to not be repeated, but here we also review recent in vivo and in vitro studies showing that manmade carbon nanofibres could pose a similar danger to human health. This should be taken seriously by regulatory bodies to ensure thorough testing of novel materials before release in the society. @ERSpublications Malignant pleural mesothelioma is a cancer with increasing death tolls due to the past and present use of asbestos http://ow.ly/DhA2y

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Section: Potential Mechanisms Of Cnt Oncogenesismentioning

confidence: 77%

Malignant pleural mesothelioma: history, controversy and future of a manmade epidemic

2015

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“…Such detection/quantification of phenotypic changes is based on the analysis of cell images employing image analysis software following exposure to tested molecules and specific staining(12, 13). HCS allows screening large numbers of molecules, while simultaneously obtaining multi-parametric information about their effects on cells.…”

Section: Introductionmentioning

confidence: 99%

A novel image-based high-throughput screening assay discovers therapeutic candidates for adult polyglucosan body disease

Solmesky

Khazanov

Senderowitz

et al. 2017

Biochemical Journal

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Glycogen storage disorders (GSDs) are caused by excessive accumulation of glycogen. Some GSDs (Adult Polyglucosan Body Disease (APBD), Tarui and Lafora diseases) are caused by intracellular accumulation of insoluble inclusions, called polyglucosan bodies (PB), which are chiefly composed of malconstructed glycogen. We developed an APBD patient skin fibroblast cell-based assay for PB identification, where the bodies are identified as amylase-resistant periodic acid-Schiff’s (PAS) stained structures, and quantified. We screened the DIVERSet-CL 10,084 compound library using this assay in high throughput format and discovered 11 dose-dependent and 8 non dose-dependent PB-reducing hits. ~70% of the hits appear to act through reducing glycogen synthase (GS) activity which can elongate glycogen chains and presumably promote PB generation. Some of these GS inhibiting hits were also computationally predicted to be similar to drugs interacting with the GS activator protein phosphatase 1 (PP1). Our work paves the way to discovering medications for the treatment of PB-involving GSD, which are extremely severe or fatal disorders.

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“…[40] An additional strategy for immune protection and increasing the solubility of highly insoluble single-walled carbon nanotubes (SWCNTs) with a combined phospholipid and HA coating was recently documented. [41] As demonstrated for other NPs, the HA coating endowed the SWCNTs with stealth properties, allowing them to evade the immune system. The authors showed reduced immune and mitochondrial toxicity for the coated SWCNTs.…”

Section: Ha-coated Npsmentioning

confidence: 92%

Sweet Fairytale: Carbohydrates as Backbones for Glyconanomedicine

Mizrahy¹,

Landesman-Milo²,

Peer³

2013

Israel Journal of Chemistry

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The use of nanoparticles (NPs) in medical applications is rapidly growing, with more than 30 NP‐based drugs approved for clinical use. Different building blocks are used to generate NPs for drug and imaging delivery tasks. Among them, carbohydrates represent an exciting option that is currently being exploited in vivo and in clinical trials. Carbohydrates have excellent biocompatibility, biodegradability, low toxicity, and low cost. In addition, the ease of chemical modification enables the preparation of a wide collection of NPs for a variety of tasks. Here, we will describe the properties of common carbohydrates and the main mechanisms for carbohydrates‐based NP preparation and discuss several key concepts from the physicochemical and structural features of NP‐based carbohydrates for pre‐clinical and clinical applications.

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Structural profiling and biological performance of phospholipid–hyaluronan functionalized single-walled carbon nanotubes

Cited by 26 publications

References 45 publications

Malignant pleural mesothelioma: history, controversy and future of a manmade epidemic

Malignant pleural mesothelioma: history, controversy and future of a manmade epidemic

A novel image-based high-throughput screening assay discovers therapeutic candidates for adult polyglucosan body disease

Sweet Fairytale: Carbohydrates as Backbones for Glyconanomedicine

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