Three Main Factors Define Changes in Fecal Microbiota Associated With Feeding Modality in Infants

Gómez-Llorente, Carolina; Plaza‐Díaz, Julio; Aguilera, Margarita; Muñoz-Quezada, Sergio; Bermúdez-Brito, Miriam; Peso-Echarri, Patricia; Martinez-Silla, Rosario; Vasallo-Morillas, M. Isabel; Campaña-Martín, Laura; Vives-Piñera, Inmaculada; Ballesta-Martínez, María Juliana; Gil, Ángel

doi:10.1097/mpg.0b013e31829d519a

Cited by 49 publications

(35 citation statements)

References 50 publications

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“…; however, effects of feeding on Lactobacillus abundance are inconsistent across other studies. Increased proportions of Lactobacillus, 25,26,48,54 as well as greater abundances of L. gasseri 28,47 in BF compared to FF infants have been reported, whereas other studies found opposite results 16,52,53 or reported intergroup variability and instability over time. 27,43 A greater prevalence 15 and higher proportion 24 and total counts 16,46 of C. difficile in FF compared to BF infants, as well as, significantly more Peptostreptococcaceae, 31 Akkermansia, 15 Veillonella, and Enterococcus 28 have been described.…”

Section: (Finland)mentioning

confidence: 62%

“…24,39,42 While many studies have focused on bifidobacterial colonization, breastfeeding supports other differences in microbiota composition. Within the phyla Bacteroidetes and Firmicutes, BF infants contain lower levels of Bacteroides, 33,50-53 Atopobium, 51,53 Clostridiales, Lachnospiraceae, and Faecalibacterium than FF. 33 Fan and colleagues 26 found that Bifidobacterium, Streptococcus, and Lactobacillus were dominant members in both feeding groups sampled between 3 and 6 mos; other dominant genera included Clostridium in BF infants and Klebsiella and Enterococcus in FF infants.…”

Section: (Finland)mentioning

confidence: 99%

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The role of early life nutrition in the establishment of gastrointestinal microbial composition and function

2017

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The development of the human infant intestinal microbiota is a sequential process that begins in utero and continues during the first 2 to 3 years of life. Microbial composition and diversity are shaped by host genetics and multiple environmental factors, of which diet is a principal contributor. An understanding of this process is of clinical importance as the microbiota acquired in early life influence gastrointestinal, immune and neural development, and reduced microbial diversity or dysbiosis during infancy is associated with disorders in infancy and later childhood. The goal of this article was to review the published literature that used culture-independent methods to describe the development of the gastrointestinal microbiota in breast-and formula-fed human infants as well as the impact of prebiotic and probiotic addition to infant formula, and the addition of solid foods.

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Section: (Finland)mentioning

confidence: 62%

Section: (Finland)mentioning

confidence: 99%

The role of early life nutrition in the establishment of gastrointestinal microbial composition and function

2017

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“…Fecal samples were processed as previously described [16,17]. One gram of feces was homogenized in 9 mL of PBS (phosphate-buffered saline), and then 0.2 mL of the suspension was mixed with 0.6 mL of 4% paraformaldehyde (PFA) in PBS and fixed overnight at 4°C.…”

Section: Methodsmentioning

confidence: 99%

Safety and Immunomodulatory Effects of Three Probiotic Strains Isolated from the Feces of Breast-Fed Infants in Healthy Adults: SETOPROB Study

et al. 2013

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We previously described the isolation and characterization of three probiotic strains from the feces of exclusively breast-fed newborn infants: Lactobacillus paracasei CNCM I-4034, Bifidobacterium breve CNCM I-4035 and Lactobacillus rhamnosus CNCM I-4036. These strains were shown to adhere to intestinal mucus in vitro, to be sensitive to antibiotics and to resist biliary salts and low pH. In the present study, a multicenter, randomized, double-blind, placebo-controlled trial with 100 healthy volunteers in three Spanish cities was carried out to evaluate the tolerance, safety, gut colonization and immunomodulatory effects of these three probiotics. Volunteers underwent a 15-day washout period, after which they were randomly divided into 5 groups that received daily a placebo, a capsule containing one of the 3 strains or a capsule containing a mixture of two strains for 30 days. The intervention was followed by another 15-day washout period. Patients did not consume fermented milk for the entire duration of the study. Gastrointestinal symptoms, defecation frequency and stool consistency were not altered by probiotic intake. No relevant changes in blood and serum, as well as no adverse events occurred during or after treatment. Probiotic administration slightly modified bacterial populations in the volunteers’ feces. Intestinal persistence occurred in volunteers who received L. rhamnosus CNCM I-4036. Administration of B. breve CNCM I-4035 resulted in a significant increase in fecal secretory IgA content. IL-4 and IL-10 increased, whereas IL-12 decreased in the serum of volunteers treated with any of the three strains. These results demonstrate that the consumption of these three bacterial strains was safe and exerted varying degrees of immunomodulatory effects.Trial RegistrationClinicalTrials.gov NCT01479543

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“…Their colonization after birth occurs through the vertical transfer of gut microbiota from the mother to the neonate [2,3] and is influenced by several factors [4] such as gestational age at birth [5], the mode of delivery [6], use of perinatal antibiotics [7], or the mode of feeding [8]. Recent studies have shown that one of the main sources of bifidobacteria is breast milk [9,10,11].…”

Section: Introductionmentioning

confidence: 99%

Maternal Prebiotic Ingestion Increased the Number of Fecal Bifidobacteria in Pregnant Women but Not in Their Neonates Aged One Month

Jinno¹,

Toshimitsu²,

Nakamura³

et al. 2017

Nutrients

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Fructooligosaccharides (FOS) can selectively stimulate the growth of bifidobacteria. Here, we investigated the effect of maternal FOS ingestion on maternal and neonatal gut bifidobacteria. In a randomized, double-blind, placebo-controlled study, we administered 8 g/day of FOS or sucrose to 84 women from the 26th week of gestation to one month after delivery. The bifidobacteria count was detected using quantitative PCR in maternal (26 and 36 weeks of gestation) and neonatal (one month after delivery) stools. Maternal stool frequency was recorded from 24 to 36 weeks of gestation. The number of fecal Bifidobacterium spp. and Bifidobacterium longum in the FOS group was significantly higher than that in the placebo group at 36 weeks of gestation (2.7 × 1010/g vs. 1.1 × 1010/g and 2.3 × 1010/g vs. 9.7 × 109/g). In their neonates, these numbers did not differ between the groups. Also, stool frequency in the FOS group was slightly higher than that in the placebo group two weeks after the intervention (1.0 vs. 0.8 times/day), suggesting a potential constipation alleviation effect. In conclusion, the maternal FOS ingestion showed a bifidogenic effect in pregnant women but not in their neonates.

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Three Main Factors Define Changes in Fecal Microbiota Associated With Feeding Modality in Infants

Abstract: There is a clear clustering of components of infant microbiota based on the feeding method.

Cited by 49 publications

References 50 publications

The role of early life nutrition in the establishment of gastrointestinal microbial composition and function

The role of early life nutrition in the establishment of gastrointestinal microbial composition and function

Safety and Immunomodulatory Effects of Three Probiotic Strains Isolated from the Feces of Breast-Fed Infants in Healthy Adults: SETOPROB Study

Maternal Prebiotic Ingestion Increased the Number of Fecal Bifidobacteria in Pregnant Women but Not in Their Neonates Aged One Month

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