The influence of age and season on fecal dehydroepiandrosterone-sulfate (DHEAS) concentrations in Japanese macaques (Macaca fuscata)

Takeshita, Rafaela S. C.; Huffman, Michael A.; Bercovitch, Fred B.; Mouri, Keiko; Shimizu, Keiko

doi:10.1016/j.ygcen.2013.05.019

Cited by 16 publications

(16 citation statements)

References 43 publications

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“…Our findings showed that season did not affect fecal DHEAS levels, in agreement with our previous study [Takeshita et al, ], although in some captive male squirrel monkeys ( Saimiri boliviensis boliviensis ) [Wiebe et al, ] and lemurs ( Microcebus murinus ) [Perret & Aujard, ], DHEAS levels appear to be elevated during the breeding (mating) season.…”

Section: Discussionsupporting

confidence: 93%

“…The age effect on fecal DHEAS and fGC presented here is consistent with our previous study in female Japanese macaques [Takeshita et al, ]. In addition, we found that the age‐related decline in DHEAS was stronger in the individuals housed indoor in single cages compared to those housed outdoor in social groups.…”

Section: Discussionsupporting

confidence: 92%

“…For DHEAS, we used a DHEAS ELISA kit developed for human serum (ALPCO Diagnostics, Salem, NH). The details of the assay methods have been previously described and validated for measurement of fecal DHEAS in Japanese macaques [Takeshita et al, ]. Standards, internal controls and fecal extracts were assayed in duplicate.…”

Section: Methodsmentioning

confidence: 99%

“…Nevertheless, the association between stress levels and DHEAS is not well elucidated due to the limited data in the literature. In Japanese macaques ( Macaca fuscata ), fecal samples have been used to monitor reproductive hormones [Bardi et al, ; Barrett et al, ; Fujita et al, ; Yoshida et al, ], social dominance, and cortisol levels [Barrett et al, ; MacIntosh et al, ], and seasonal impacts on steroid hormones [Muroyama et al, ; Takeshita et al, ], but few studies have been published regarding the possible impact of stress on glucocorticoids and DHEAS metabolite levels in this species. This study aimed to measure fGC and fecal DHEAS metabolites as possible indicators of stress in captive female Japanese macaques ( Macaca f. fuscata ).…”

Section: Introductionmentioning

confidence: 99%

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Environmental, biological, and social factors influencing fecal adrenal steroid concentrations in female Japanese macaques (Macaca fuscata)

Takeshita

Bercovitch

Huffman

et al. 2014

American J Primatol

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The ability to determine hormonal profiles of primate populations using non-invasive techniques can help to monitor physical fitness, stress, and physiological responses to environmental changes. We investigated fecal glucocorticoids (fGC) and DHEAS concentrations in captive Japanese macaques (Macaca fuscata) in relation to environmental, biological, and social factors. The subjects were female Japanese monkeys from 4 months to 31 years old housed in captivity (27 in social groups and 12 in single cages). Fecal samples were collected from all females, and behavioral data from the social groups during the mating season and the following birth season. Hormonal concentrations were analyzed by enzyme immunoassay. Our results revealed that both fGC and fecal DHEAS concentrations are higher in females housed indoors in single cages than in those living outdoors in social groups. We also found that fGC concentrations were higher in the cycling females during the mating (winter) season than the lactating females in the birth (spring) season. Age was negatively associated to both fGC and fecal DHEAS levels, but the relationship between age and fecal DHEAS was more evident in females housed indoors in single cages than in females housed in outdoor social groups. We did not observe any association of dominance rank with either fecal DHEAS or fGC. This study showed that measurement of fecal DHEAS and fGC can be a good method to assess stress in Japanese macaques. These findings provide insights about the physiology of these two adrenal hormones in female Japanese macaques, which can be applied to wild populations and is fundamental for captive management and conservation biology.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Environmental, biological, and social factors influencing fecal adrenal steroid concentrations in female Japanese macaques (Macaca fuscata)

Takeshita

Bercovitch

Huffman

et al. 2014

American J Primatol

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“…Rhesus macaque DHEAS levels decline with age and are not different among males and females; both seasonally and non-seasonally breeding macaque species show a decline in DHEAS levels from early life throughout postnatal life [52, 53]. Previous work focusing on the endocrine parameters of reproductive maturation in male baboons suggests that they do not show hormonal evidence of adrenarche [54].…”

Section: Adrenal Androgensmentioning

confidence: 99%

Hormones and Human and Nonhuman Primate Growth

Bernstein¹

2017

Horm Res Paediatr

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The aim of this paper was to review information pertaining to the hormonal regulation of nonhuman primate growth, with specific focus on the growth hormone (GH)-insulin-like growth factor (IGF) axis and adrenal androgens. Hormones of the GH-IGF axis are consistently associated with measures of growth – linear, weight, or both – during the growth period; in adulthood, concentrations of IGF-I, IGF-binding protein-3, and GH-binding protein are not associated with any measures of size. Comparing patterns of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) may be especially relevant for understanding whether the childhood stage of growth and development is unique to humans and perhaps other apes. Genetic, hormonal, and morphological data on adrenarche in other nonhuman primate species suggest that this endocrine transition is delayed in humans, chimpanzees, and possibly gorillas, while present very early in postnatal life in macaques. This suggests that although perhaps permitted by an extension of the pre-adolescent growth period, childhood builds upon existing developmental substrates rather than having been inserted de novo into an ancestral growth trajectory. Hormones can provide insight regarding the evolution of the human growth trajectory.

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Steroid hormone concentrations in milk predict sex‐specific offspring growth in a nonhuman primate

Petrullo

Hinde

2019

American J Hum Biol

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Objectives: In humans and other mammals, maternal hormones are transferred to offspring during lactation via milk and may regulate postnatal development, including the pace of early growth. Here, we used a nonhuman primate model to test the hypotheses that milk cortisol and dehydroepiandrosterone-sulfate (DHEAS) concentrations reflect maternal characteristics, and that changes in these hormones across lactation are associated with early postnatal growth rates. Methods: Demographic information, morphometrics, and milk samples were collected from rhesus macaque mothers and their infants at the California National Primate Research Center in Davis, California. Using linear models, we examined the relationship between maternal traits and milk hormone concentrations (N = 104 females) and explored the effect of milk hormones on the rate of offspring growth (N = 72 mother-infant dyads), controlling for available milk energy. Results: Contrary to previous studies, we found that milk cortisol concentrations were categorically higher in multiparous females than in primiparous females.However, milk DHEAS concentrations decreased with maternal parity. Neither milk cortisol nor DHEAS were related to maternal rank. Finally, changes in milk hormones predicted offspring growth in a sex-specific and temporal manner: increases in cortisol from peak to late lactation predicted faster female growth, and increases in DHEAS concentrations from early to peak and peak to late lactation predicted faster male growth. Conclusions: Our findings shed light on how hormonal components of milk have sex-specific effects on offspring growth during early postnatal life with varying temporal windows of sensitivity.

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The influence of age and season on fecal dehydroepiandrosterone-sulfate (DHEAS) concentrations in Japanese macaques (Macaca fuscata)

Cited by 16 publications

References 43 publications

Environmental, biological, and social factors influencing fecal adrenal steroid concentrations in female Japanese macaques (Macaca fuscata)

Environmental, biological, and social factors influencing fecal adrenal steroid concentrations in female Japanese macaques (Macaca fuscata)

Hormones and Human and Nonhuman Primate Growth

Steroid hormone concentrations in milk predict sex‐specific offspring growth in a nonhuman primate

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