Inhibition of Candida albicans isocitrate lyase activity by cadiolides and synoilides from the ascidian Synoicum sp.

Ahn, Chan‐Hong; Won, Tae Hyung; Kim, Heegyu; Shin, Jongheon; Oh, Ki‐Bong

doi:10.1016/j.bmcl.2013.05.051

Cited by 20 publications

(5 citation statements)

References 15 publications

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“…The harvested cells were streaked on YNB agar plates containing 2% glucose, 2% potassium acetate, or 2% potassium acetate plus 32 μg/mL cyclo(L-Phe-L-Val) and incubated at 28 °C for 2 days. For icl expression analysis, the harvested cells were added to YNB liquid broth containing 2% glucose, 2% potassium acetate, or 2% potassium acetate plus cyclo(L-Phe-L-Val) (8, 16, or 32 μg/mL) and incubated at 28 °C for 4 h. RNA extraction, cDNA synthesis, and semi-quantitative RT-PCR were performed using previously described methods [33]. GPDH was used as the loading control.…”

Section: Methodsmentioning

confidence: 99%

Inhibitory Effects of Diketopiperazines from Marine-Derived Streptomyces puniceus on the Isocitrate Lyase of Candida albicans

et al. 2019

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The glyoxylate cycle is a sequence of anaplerotic reactions catalyzed by the key enzymes isocitrate lyase (ICL) and malate synthase, and plays an important role in the pathogenesis of microorganisms during infection. An icl-deletion mutant of Candida albicans exhibited reduced virulence in mice compared with the wild type. Five diketopiperazines, which are small and stable cyclic peptides, isolated from the marine-derived Streptomyces puniceus Act1085, were evaluated for their inhibitory effects on C. albicans ICL. The structures of these compounds were elucidated based on spectroscopic data and comparisons with previously reported data. Cyclo(L-Phe-L-Val) was identified as a potent ICL inhibitor, with a half maximal inhibitory concentration of 27 μg/mL. Based on the growth phenotype of the icl-deletion mutants and icl expression analyses, we demonstrated that cyclo(L-Phe-L-Val) inhibits the gene transcription of ICL in C. albicans under C2-carbon-utilizing conditions.

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Section: Methodsmentioning

confidence: 99%

Inhibitory Effects of Diketopiperazines from Marine-Derived Streptomyces puniceus on the Isocitrate Lyase of Candida albicans

et al. 2019

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“…Additionally, Won et al [ 68 ] reported cadiolides E–H ( 102 – 105 ) from another ascidian Synoicum sp. Both compounds ( 102, 105 ) showed a potent anti-fungal activity zone growth inhibitory with C. albicans (IC 50 values of 7.62, 10.36 µM) [ 80 ]. Searle and Molinski [ 81 ] isolated the anti-fungal 2-amino alcohol ( 134 ) and their derivatives ( 134a, b ) from the Australian Didemnum sp.…”

Section: Pharmacological Activity Of Ascidian Compoundsmentioning

confidence: 99%

Natural Products Diversity of Marine Ascidians (Tunicates; Ascidiacea) and Successful Drugs in Clinical Development

Palanisamy

Rajendran

Marino

2017

Nat. Prod. Bioprospect.

104

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This present study reviewed the chemical diversity of marine ascidians and their pharmacological applications, challenges and recent developments in marine drug discovery reported during 1994–2014, highlighting the structural activity of compounds produced by these specimens. Till date only 5% of living ascidian species were studied from <3000 species, this study represented from family didemnidae (32%), polyclinidae (22%), styelidae and polycitoridae (11–12%) exhibiting the highest number of promising MNPs. Close to 580 compound structures are here discussed in terms of their occurrence, structural type and reported biological activity. Anti-cancer drugs are the main area of interest in the screening of MNPs from ascidians (64%), followed by anti-malarial (6%) and remaining others. FDA approved ascidian compounds mechanism of action along with other compounds status of clinical trials (phase 1 to phase 3) are discussed here in. This review highlights recent developments in the area of natural products chemistry and biotechnological approaches are emphasized.

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“…), beta-carboline alkaloid [ 57 ] ( Synoicum sp. ), sphingolipid [ 58 ] ( Spirastrella abata ), and tris-aromatic furanones [ 59 ] ( Synoicum sp.). Their IC 50 are 50–95 μ g/mL, 28.7 to >200 μ g/mL, 12.5–19.9 μ g/mL, 31.3–33.8 μ M, 89 μ M, 118.4–172.9 μ M, 40.8–55.3 μ M, 5–17 μ M, 10.8 μ M, 48.2–68.9 μ M, 2–87 μ M, and 7.62–10.36 μ M, respectively.…”

Section: Discovery Of Isocitrate Lyase Potential Inhibitors From Dmentioning

confidence: 99%

Potential Inhibitors for Isocitrate Lyase ofMycobacterium tuberculosisand Non-M. tuberculosis: A Summary

Lee

Wahab

Choong

2015

BioMed Research International

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Isocitrate lyase (ICL) is the first enzyme involved in glyoxylate cycle. Many plants and microorganisms are relying on glyoxylate cycle enzymes to survive upon downregulation of tricarboxylic acid cycle (TCA cycle), especially Mycobacterium tuberculosis (MTB). In fact, ICL is a potential drug target for MTB in dormancy. With the urge for new antitubercular drug to overcome tuberculosis treat such as multidrug resistant strain and HIV-coinfection, the pace of drug discovery has to be increased. There are many approaches to discovering potential inhibitor for MTB ICL and we hereby review the updated list of them. The potential inhibitors can be either a natural compound or synthetic compound. Moreover, these compounds are not necessary to be discovered only from MTB ICL, as it can also be discovered by a non-MTB ICL. Our review is categorized into four sections, namely, (a) MTB ICL with natural compounds; (b) MTB ICL with synthetic compounds; (c) non-MTB ICL with natural compounds; and (d) non-MTB ICL with synthetic compounds. Each of the approaches is capable of overcoming different challenges of inhibitor discovery. We hope that this paper will benefit the discovery of better inhibitor for ICL.

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Inhibition of Candida albicans isocitrate lyase activity by cadiolides and synoilides from the ascidian Synoicum sp.

Cited by 20 publications

References 15 publications

Inhibitory Effects of Diketopiperazines from Marine-Derived Streptomyces puniceus on the Isocitrate Lyase of Candida albicans

Inhibitory Effects of Diketopiperazines from Marine-Derived Streptomyces puniceus on the Isocitrate Lyase of Candida albicans

Natural Products Diversity of Marine Ascidians (Tunicates; Ascidiacea) and Successful Drugs in Clinical Development

Potential Inhibitors for Isocitrate Lyase ofMycobacterium tuberculosisand Non-M. tuberculosis: A Summary

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