Adiponectin levels in patients with psoriasis: A meta‐analysis

Abstract

Conflicting results regarding adiponectin levels in patients with psoriasis have been reported. We carried out a meta-analysis on studies which compared adiponectin levels of psoriatic patients with controls. A published work search was performed through PubMed (MEDLINE), EMBASE and the Cochrane Library for articles published in English. Pooled standardized mean difference (SMD) and 95% confidence intervals (95% CI) were calculated by using random effects and fixed effect models. Heterogeneity between studies was assessed using the Cochran's Q and I(2) statistics. A total of nine studies were enrolled (389 cases and 360 controls) for adiponectin, and three studies were included (132 cases and 132 controls) for high-molecular weight (HMW) adiponectin. Adiponectin and HMW adiponectin levels were not significantly different in patients with psoriasis compared with controls (SMD, -0.151 [95% CI, -0.616 to 0.315]; P = 0.526 for adiponectin; SMD, 0.999 [95% CI, -2.626 to 4.624]; P = 0.589 for HMW adiponectin). The associations were borderline significantly different in the stratum of those with a mean age of less than 40 years (SMD, -0.516 [95% CI: -1.032 to 0]; P = 0.050). Sensitivity analyses were not substantially altered in the direction of effect when any one study was excluded. No publication bias was detected. The level of adiponectin and HMW adiponectin may not be associated with psoriasis. The relationship between psoriasis and adipokines needs more in-depth studies with larger sample sizes.

Serum Leptin, Resistin, and Adiponectin Concentrations in Psoriasis: A Meta-Analysis of Observational Studies

“…Our study confirms the results of other meta-analyses that have been previously performed on the same topic [9][10][11]. Nevertheless, the novelty of the present metaanalysis consists of (i) inclusion of all 3 types of adipokines together, providing the most complete and comprehensive aspect of this key issue and (ii) analysis of more than double the number of studies compared to previous meta-analyses, making it an updated review in the field.…”

“…Recent studies suggest that adipokines, such as leptin, resistin, and adiponectin, may be implicated in the pathogenesis of psoriasis [9][10][11]. Both leptin and resistin are known to promote the production of proinflammatory mediators involved in the pathogenesis of psoriasis, such as TNF-α and CXCL8 [12].…”

Psoriasis and Obesity

“…Several studies have suggested that lower levels are found in patients with psoriasis which correlate inversely with the severity of psoriasis [29,55,56] . However, evidence is conflicting as a recent meta-analysis found no difference between adiponectin levels in patients with psoriasis and controls [57] . At this point, it is reasonable to wonder whether perhaps there may be a common genetic predisposition for developing both psoriasis and obesity or through which mechanisms the presence of obesity might predispose to psoriasis and vice versa.…”

Effects of treatment for psoriasis on circulating levels of leptin, adiponectin and resistin: a systematic review and meta-analysis

“…According to the most recent scientific evidence, the visceral adipose tissue not only serves to store energy but is also an important player in the immune‐mediated processes and inflammation, and represents an active endocrine organ producing various bioactive adipokines, such as leptin, adiponectin and resistin . Recent studies suggested that circulating adipokine concentrations are altered in patients with psoriasis and are suggested to represent the pathophysiological link between psoriatic lesions and metabolic alterations . Both leptin and resistin are known to promote the production of proinflammatory mediators involved in the pathogenesis of psoriasis, such as TNF‐α and CXCL8 .…”