Risk of childhood leukaemia and non-Hodgkin's lymphoma after parental occupational exposure to solvents and other agents: the SETIL Study

Abstract

AimIn the context of the Italian Multicentric Epidemiological Study on Risk Factors for Childhood Leukaemia and Non-Hodgkin's Lymphoma (SETIL), the risk of childhood cancer was investigated in relation to parental occupational exposures. Methods All cases of childhood leukaemia and non-Hodgkin's lymphoma (NHL) in children aged 0-10 years were identified. Controls were chosen at random from the local population in each region. Parents were interviewed using a structured questionnaire. The collected data were blindly reviewed by expert industrial hygienists in order to estimate exposure to a list of agents. Statistical analyses were performed for each agent using unconditional multivariable logistic regression models, taking into account timing of exposure. Results 683 cases of acute childhood leukaemia, 97 cases of NHL and 1044 controls were identified.

Parental occupational exposure to benzene and the risk of childhood cancer: A census-based cohort study

“…Similarly, positive associations have been reported for childhood lymphoma and paternal occupation in the shoe and leather industry (Mutanen and Hemminki 2001), non-Hodgkin lymphoma and maternal occupational exposure to solvents (McKinney et al 2008), and non-Hodgkin lymphoma and paternal exposure to oxygenated solvents and petrol exhaust (Miligi et al 2013). Our study does not support a causative role of benzene for these cancer types.…”

“…Results from studies that have specifically investigated occupational exposure to benzene also tend to support a link with childhood leukaemia, particularly for maternal exposure (Carlos-Wallace et al 2016). Since the review by Colt and Blair, increased risks in children of parents with benzene related occupational exposures have also been reported for CNS tumours (Ali et al 2004;Cordier et al 1997;Cordier et al 2001;Keegan et al 2013;McKean-Cowdin et al 1998;Peters et al 2014;Peters et al 2013), lymphoma (Mutanen and Hemminki 2001), and non-Hodgkin lymphoma (McKinney et al 2008;Miligi et al 2013). …”

“…A review of studies up to 1997 supports increased risks associated with benzene-related occupational exposures such as exposure to paints, solvents or exhaust fumes both for childhood leukaemia and CNS tumours (Colt and Blair 1998). For childhood leukaemia, The majority of more recent studies have also reported increased risks associated with benzene-related occupational exposures, either for paternal (Feychting et al 2001;Metayer et al 2016;Miligi et al 2013;Reid et al 2011) or maternal exposure (Infante-Rivard et al 2005;McKinney et al 2008;Miligi et al 2013;Reid et al 2011;Schuz et al 2000;Shu et al 1999). However, two large recent studies (Bailey et al 2014;Keegan et al 2012), including a study of 5 the Childhood Leukaemia International Consortium (CLIC) focusing on parental occupational exposure to paint (Bailey et al 2014), found no evidence of an association.…”

Clinicopathologic and Survival Characteristics of Childhood and Adolescent Non Hodgkin's Lymphoma in Yazd, Iran

“…Fariba Binesh 1 , Ali Akhavan 2 *, Nasim Behniafard 3 , Aref Atefi 4 oxygenated solvent and petrol exhausts (Miligi et al, 2013). Depending on the geographic region being studied, there are important differences in relation to the clinical and epidemiological characteristics of non-Hodgkin lymphomas diagnosed during childhood (Sandlund et al, 1996).…”

Avaliação da influência de fatores ambientais sobre o diagnóstico de artrite idiopática juvenil em crianças e adolescentes

“…Na literatura, a exposição ocupacional materna tem recebido pouca atenção nas últimas décadas, e essa questão não havia sido estudada anteriormente na AIJ. Alguns estudos observaram uma associação positiva entre exposição ocupacional materna e outras doenças em crianças como leucemia, 65,66 linfoma não-Hodgkin 65 e DMJ, 19 apresentando, este último estudo, um risco aumentado em 35 vezes.…”