Novel ideas about salt, blood pressure, and pregnancy

Rakova, Natalia; Müller, Dominik N.; Staff, Anne Cathrine; Luft, Friedrich C.; Dechend, Ralf

doi:10.1016/j.jri.2013.04.001

Cited by 8 publications

(5 citation statements)

References 25 publications

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“…A meta-analysis restricted to LMIC reported a significant effect of omega-3 supplementation on preeclampsia (RR 0.40, 95% CI: 0.21-0.77, I 2 0%, six studies, N=1343), but there was no difference in severe preeclampsia, eclampsia, or gestational hypertension. 133 There are also some intriguing possibilities that deserve further studies, including periconceptional vitamins, [135][136][137] dietary nitrates, 138 reduced sodium intake 139 and antioxidants other than vitamins C and E, but thus far none have been of proven benefit. 140 Omega-3 supplementation reduced the risk of early preterm delivery at < 34 weeks (RR 0.42, 95% CI 0.27-0.66, p=0.0002, 6 studies, n=4193) and any preterm birth (RR 0.83, 95% CI 0.70-0,98, p=0.03, 9 studies, n=5980) according to a systematic review.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

“…A meta-analysis restricted to LMICs reported a significant effect of omega-3 supplementation on preeclampsia (risk ratio [RR], 0.40; 95% confidence interval [CI], 0.21–0.77; I 2 , 0%; 6 studies, n=1343), but there was no difference in severe preeclampsia, eclampsia, or gestational hypertension. 136 Moreover, some intriguing possibilities deserve further studies, including periconceptional vitamins, 138 – 140 dietary nitrates, 141 reduced sodium intake, 142 and antioxidants other than vitamins C and E, but thus far, none has been of proven benefit. 143 …”

Section: The Consumption Of a Beneficial Dietary Pattern Before And D...mentioning

confidence: 99%

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The importance of nutrition in pregnancy and lactation: lifelong consequences

Marshall¹,

Abrams²,

Barbour³

et al. 2022

American Journal of Obstetrics and Gynecology

165

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Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Section: The Consumption Of a Beneficial Dietary Pattern Before And D...mentioning

confidence: 99%

The importance of nutrition in pregnancy and lactation: lifelong consequences

Marshall¹,

Abrams²,

Barbour³

et al. 2022

American Journal of Obstetrics and Gynecology

165

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“…Recent studies indicate their likely function in immune tolerance (16), and together with angiogenesis, are considered the key processes for normal placentation. VEGF-C has been also suggested to link the immune system in pregnancy with sodium and fluid homeostases, which are involved in the pathogenesis of preeclampsia (17).…”

Section: Introductionmentioning

confidence: 99%

VEGF-A and VEGFR1 SNPs associate with preeclampsia in a Philippine population

Amosco

et al. 2016

Clinical and Experimental Hypertension

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The vascular endothelial growth factor (VEGF) family is important for establishing normal pregnancy, and related single nucleotide polymorphisms (SNPs) are implicated in abnormal placentation and preeclampsia. We evaluated the association between preeclampsia and several VEGF SNPs among Filipinos, an ethnically distinct group with high prevalence of preeclampsia. The genotypes and allelic variants were determined in a case-control study (191 controls and 165 preeclampsia patients) through SNP analysis of VEGF-A (rs2010963, rs3025039) and VEGF-C (rs7664413) and their corresponding receptors VEGFR1 (rs722503, rs12584067, rs7335588) and VEGFR3 (rs307826) from venous blood DNA. VEGF-A rs3025039 C allele has been shown to associate with preeclampsia (odds ratio of 1.648 (1.03-2.62)), while the T allele bestowed an additive effect for the maintenance of normal, uncomplicated pregnancy and against the development of preeclampsia (odds ratio of 0.62 (0.39-0.98)). VEGFR1 rs722503 is associated with preeclampsia occurring at or after the age of 40 years. The results showed that genetic variability of VEGF-A and VEGFR1 are important in the etiology of preeclampsia among Filipinos.

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“…This is explained by a more pronounced decrease of vasodilating than vasoconstricting circulating RAAS components [23]. Increase of aldosterone and plasma volume expansion is less pronounced in preeclampsia than in normal pregnancy [24,25] and this is associated with an increased interstitial concentration of salt with subsequent immune response [26]. Next to this, the number of placental AT1 receptors increases together with the alternative conversion to angII and subsequent increased release of endothelin 1.…”

Section: Renal Physiology In Normal Pregnancy and In Two Types Of mentioning

confidence: 99%

Maternal Venous Hemodynamic Dysfunction in Proteinuric Gestational Hypertension: Evidence and Implications

Gyselaers

2019

JCM

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This review summarizes current knowledge from experimental and clinical studies on renal function and venous hemodynamics in normal pregnancy, in gestational hypertension (GH) and in two types of preeclampsia: placental or early-onset preeclampsia (EPE) and maternal or late-onset (LPE) preeclampsia, presenting at <34 weeks and ≥34 weeks respectively. In addition, data from maternal venous Doppler studies are summarized, showing evidence for (1) the maternal circulation functioning closer to the upper limits of capacitance than in non-pregnant conditions, with intrinsic risks for volume overload, (2) abnormal venous Doppler measurements obtainable in preeclampsia, more pronounced in EPE than LPE, however not observed in GH, and (3) abnormal venous hemodynamic function installing gradually from first to third trimester within unique pathways of general circulatory deterioration in GH, EPE and LPE. These associations have important clinical implications in terms of screening, diagnosis, prevention and management of gestational hypertensive diseases. They invite for further hypothesis-driven research on the role of retrograde venous congestion in the etiology of preeclampsia-related organ dysfunctions and their absence in GH, and also challenge the generally accepted view of abnormal placentation as the primary cause of preeclampsia. The striking similarity between abnormal maternal venous Doppler flow patterns and those observed at the ductus venosus and other abdominal veins of the intra-uterine growth restricted fetus, also invites to explore the role of venous congestion in the intra-uterine programming of some adult diseases.

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Novel ideas about salt, blood pressure, and pregnancy

Cited by 8 publications

References 25 publications

The importance of nutrition in pregnancy and lactation: lifelong consequences

The importance of nutrition in pregnancy and lactation: lifelong consequences

VEGF-A and VEGFR1 SNPs associate with preeclampsia in a Philippine population

Maternal Venous Hemodynamic Dysfunction in Proteinuric Gestational Hypertension: Evidence and Implications

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