Normalisation of Angiogenic Imbalance after Intra-Uterine Transfusion for Mirror Syndrome Caused by Parvovirus B19

Goa, Satoko; Mimura, Kazuya; Kakigano, Aiko; Tomimatsu, Takuji; Kinugasa-Taniguchi, Yukiko; Endo, Masayuki; Kanagawa, Takeshi; Kimura, Tadashi

doi:10.1159/000348778

Cited by 32 publications

(22 citation statements)

References 15 publications

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“…For example, Llurba et al [28] described an unbalanced anti-angiogenic state in pregnancy complicated by hydrops fetalis. In a different case, low PlGF levels returned to normal values after treatment of fetal hydrops related to parvo B19 infection by intrauterine blood transfusion [29]. Finally, in a comprehensive longitudinal study of pregnancy, where most pregnancy complications were not placenta related, lower than normal PlGF levels were found in cases that eventually resulted in fetal death [18].…”

Section: Discussionmentioning

confidence: 92%

Placental growth factor concentration in maternal circulation decreases after fetal death: lessons from a case series study

Beharier

Shusterman

Szaingurten-Solodkin

et al. 2015

Arch Gynecol Obstet

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Section: Discussionmentioning

confidence: 92%

Placental growth factor concentration in maternal circulation decreases after fetal death: lessons from a case series study

Beharier

Shusterman

Szaingurten-Solodkin

et al. 2015

Arch Gynecol Obstet

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“…Interestingly, some case reports have shown that in the exceptional cases of PE in whom placental function improves and symptoms wear off -paradigmatically in mirror syndrome with fetal hydrops of reversible etiologythe initially elevated sFlt-1/PlGF ratio returns to normal values [36,37]. These dynamic variations according to the clinical situation are not so obvious for other classical features of PE, such as uterine artery Doppler, uric acid, liver enzymes, creatinine, or even blood pressure and proteinuria [16,22,33].…”

Section: Aid In Management and Prognosismentioning

confidence: 99%

Update on the Diagnosis and Prognosis of Preeclampsia with the Aid of the sFlt-1/ PlGF Ratio in Singleton Pregnancies

et al. 2017

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Preeclampsia (PE) is involved in a group of obstetrical conditions closely related by the presence of placental dysfunction (PD), which also includes intrauterine growth restriction and placental abruption. The timely and accurate recognition and management of PE are often challenging because diagnostic criteria are still based on nonspecific signs and symptoms and because common severity criteria correlate poorly with adverse maternal and fetal outcomes. The discovery of the role of angiogenesis-related factors - soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) - in the underlying pathophysiology of PD has marked an important step for improving its early diagnosis and prognosis assessment before gestational week 34. Nowadays, an sFlt-1/PlGF ratio cutoff level of ≤38 is widely accepted for ruling out PE in patients with suspicion of the disease, and its use is cost-effective. However, the evidence is more limited regarding the management and prognosis of women with an abnormally high sFlt-1/PlGF ratio. This review summarizes the current evidence of the clinical application of the sFlt-1/PlGF ratio for the diagnosis and prognosis assessment of PE and points out the next challenges for these biomarkers, including their role as target for the development and monitoring of new therapies.

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“…Additionally, we found remarkable increase in serum hCG level. Elevation of serum hCG is known as a feature of MS [ 5 ]. Considering that hydantidiform mole, another disease characterized by hydropic change of villi, also shows high hCG level in the peripheral blood, hCG might be related to placental damage caused by edematous tissue change.…”

Section: Discussionmentioning

confidence: 99%

Elevation of maternal serum sFlt-1 in pregnancy with mirror syndrome caused by fetal cardiac failure

Katoh

Seyama

Mimura

et al. 2018

Oxford Medical Case Reports

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Mirror syndrome (MS) is characterized by the combination of maternal generalized edema, fetal hydrops and placental hypertrophy. A shift of the serum placenta-derived angiogenic factor like sFlt-1 in MS is similar to that in pre-eclampsia (PE). We experienced a MS case caused by cardiac myopathy in the fetus with normal cardiac structure. A 27-year-old primiparous woman at 28 weeks of gestation had systemic edema without hypertension and proteinuria. Her symptoms rapidly disappeared after delivery. Compared with previously reported MS cases with maternal hypertension or proteinuria, the serum sFlt-1 level was lower in our case. Severity of maternal symptoms in MS might be paralleled with the serum sFlt-1 level. Additionally, serum hCG level in MS is much higher than that in PE. Maternal edema rather than hypertension and proteinuria can be more remarkable in MS compared with PE. It can be potentially explained by increased serum hCG level.

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Normalisation of Angiogenic Imbalance after Intra-Uterine Transfusion for Mirror Syndrome Caused by Parvovirus B19

Cited by 32 publications

References 15 publications

Placental growth factor concentration in maternal circulation decreases after fetal death: lessons from a case series study

Placental growth factor concentration in maternal circulation decreases after fetal death: lessons from a case series study

Update on the Diagnosis and Prognosis of Preeclampsia with the Aid of the sFlt-1/ PlGF Ratio in Singleton Pregnancies

Elevation of maternal serum sFlt-1 in pregnancy with mirror syndrome caused by fetal cardiac failure

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