Metabolic Syndrome as a Peculiar Target for Management of Prostate Cancer Patients

Conteduca, Vincenza; Lorenzo, Giuseppe Di; Bozza, G.; Ardito, Raffaele; Aieta, Michele

doi:10.1016/j.clgc.2013.04.009

Cited by 18 publications

(20 citation statements)

References 95 publications

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“…Furthermore, MetS is associated with worse prognosis in prostate cancer patients, including higher tumor grade, recurrence and increased mortality. 55 Yet, a substantial body of work exists in support of exercise as a therapeutic intervention for favorably altering MetS variables, albeit in populations other than cancer survivors. In addition, exercise interventions conducted in prostate cancer survivors on ADT suggest that various forms of exercise programs, including resistance, aerobic and high-intensity interval training, are safe and well-tolerated by patients, and may beneficially modify cardio-metabolic risk factors.…”

Section: Resultsmentioning

confidence: 99%

“…55 Indeed, much support for improving MetS variables through exercise has been demonstrated in a variety of populations, including healthy adults, individuals with MetS, older adults and patients with type 2 diabetes mellitus. 9-11 Yet, it is important to note that other lifestyle factors, including diet, smoking and alcohol use, may also contribute to MetS.…”

Section: Exercise As An Intervention For Metabolic Syndromementioning

confidence: 99%

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A review of clinical effects associated with metabolic syndrome and exercise in prostate cancer patients

Kiwata

Dorff

Schroeder

et al. 2016

Prostate Cancer Prostatic Dis

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Androgen deprivation therapy (ADT), a primary treatment for locally advanced or metastatic prostate cancer, is associated with adverse effects on numerous physiologic parameters, including alterations in cardio-metabolic variables that overlap with components of the metabolic syndrome (MetS). As MetS is an established risk factor for cardiovascular mortality and treatment for prostate cancer has been associated with the development of MetS, interventions targeting cardio-metabolic factors have been investigated in prostate cancer patients to attenuate the detrimental effects of ADT. Much support exists for exercise interventions in improving MetS variables in insulin resistant adults, but less evidence is available in men with prostate cancer. Regular exercise, when performed at appropriate intensities and volumes, can elicit improvements in ADT-related adverse effects, including MetS, and contributes to the growing body of literature supporting the role of exercise in cancer survivorship. This review 1) discusses the biologic interrelationship between prostate cancer, ADT, and MetS, 2) evaluates the current literature in support of exercise in targeting MetS, and 3) describes the physiological mechanisms by which exercise may favorably alter MetS risk factors in prostate cancer patients on ADT.

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Section: Resultsmentioning

confidence: 99%

Section: Exercise As An Intervention For Metabolic Syndromementioning

confidence: 99%

A review of clinical effects associated with metabolic syndrome and exercise in prostate cancer patients

Kiwata

Dorff

Schroeder

et al. 2016

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

show abstract

“…Another explanation may be related to the potential contribution of MetS to the subsequent development of PCa. 19 Conteduca et al 19 reported that testosterone levels are inversely related to total cholesterol, LDL cholesterol, and triglycerides, and positively related to serum HDL cholesterol. This finding suggests that MetS may be an important aetiological factor in the development of prostate cancer, and may help explain why patients with PCa tend to have a higher prevalence of MetS, even without ADT.…”

Section: Discussionmentioning

confidence: 99%

SIMBOSPROST: Prevalence of metabolic syndrome and osteoporosis in prostate cancer patients treated with radiotherapy and androgen deprivation therapy: A multicentre, cross-sectional study

Ots

García

Kavadoy

et al. 2015

Reports of Practical Oncology & Radiotherapy

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“…A pilot study has shown a strong trend between metabolic syndrome and earlier development of castration-resistant PCa in patients receiving ADT (109). These findings suggest that there may be a unique therapeutic window for combining insulin-sensitizing medication with antiandrogen agents for treatment of patients with PCa affected by metabolic syndrome and advanced PCa (110,111). …”

Section: Future Prospectsmentioning

confidence: 96%

Androgen Receptor Roles in Insulin Resistance and Obesity in Males: The Linkage of Androgen-Deprivation Therapy to Metabolic Syndrome

Lin

Sparks

et al. 2014

Diabetes

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Prostate cancer (PCa) is one of the most frequently diagnosed malignancies in men. Androgen-deprivation therapy (ADT) is the first-line treatment and fundamental management for men with advanced PCa to suppress functions of androgen/androgen receptor (AR) signaling. ADT is effective at improving cancer symptoms and prolonging survival. However, epidemiological and clinical studies support the notion that testosterone deficiency in men leads to the development of metabolic syndrome that increases cardiovascular disease risk. The underlying mechanisms by which androgen/AR signaling regulates metabolic homeostasis in men are complex, and in this review, we discuss molecular mechanisms mediated by AR signaling that link ADT to metabolic syndrome. Results derived from various AR knockout mouse models reveal tissue-specific AR signaling that is involved in regulation of metabolism. These data suggest that steps be taken early to manage metabolic complications associated with PCa patients receiving ADT, which could be accomplished using tissue-selective modulation of AR signaling and by treatment with insulin-sensitizing agents.

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Metabolic Syndrome as a Peculiar Target for Management of Prostate Cancer Patients

Cited by 18 publications

References 95 publications

A review of clinical effects associated with metabolic syndrome and exercise in prostate cancer patients

A review of clinical effects associated with metabolic syndrome and exercise in prostate cancer patients

SIMBOSPROST: Prevalence of metabolic syndrome and osteoporosis in prostate cancer patients treated with radiotherapy and androgen deprivation therapy: A multicentre, cross-sectional study

Androgen Receptor Roles in Insulin Resistance and Obesity in Males: The Linkage of Androgen-Deprivation Therapy to Metabolic Syndrome

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