Rough titanium alloys regulate osteoblast production of angiogenic factors

Olivares-Navarrete, René; Hyzy, Sharon L.; Gittens, Rolando A.; Schneider, Jennifer M.; Haithcock, David A.; Ullrich, Peter; Slosar, Paul; Schwartz, Zvi; Boyan, Barbara D.

doi:10.1016/j.spinee.2013.03.047

Cited by 113 publications

(89 citation statements)

References 47 publications

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“…The results showed that PB treatment restricted angiogenesis and decreased the expression of angiogenesis-related genes, HIF-1, MMP9, VEGFA, VEGF-R1, and VEGF-R2, which indeed could support the above observations (Figure 7, Supplementary Figure 4). Those angiogenesis-related genes play crucial roles in angiogenesis during bone growth and development (Araldi and Schipani, 2010;Olivares-Navarrete et al, 2013). Both in vivo and in vitro experiments on angiogenesis appear to validate our above hypothesis.…”

Section: Discussionsupporting

confidence: 72%

Exposure to excess phenobarbital negatively influences the osteogenesis of chick embryos

Yu¹

2017

J Pharm Drug Deliv Res

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Phenobarbital is an antiepileptic drug that is widely used to treat epilepsy in a clinical setting. However, a long term of phenobarbital administration in pregnant women may produce side effects on embryonic skeletogenesis. In this study, we aim to investigate the mechanism by which phenobarbital treatment induces developmental defects in long bones. We first determined that phenobarbital treatment decreased chondrogenesis and inhibited the proliferation of chondrocytes in chick embryos. Phenobarbital treatment also suppressed mineralization in both in vivo and in vitro long bone models. Next, we established that phenobarbital treatment delayed blood vessel invasion in a cartilage template, and this finding was supported by the down-regulation of vascular endothelial growth factor in the hypertrophic zone following phenobarbital treatment. Phenobarbital treatment inhibited tube formation and the migration of human umbilical vein endothelial cells. In addition, it impaired angiogenesis in chick yolk sac membrane model and chorioallantoic membrane model. In summary, phenobarbital exposure led to shortened lengths of long bones during embryogenesis, which might result from inhibiting mesenchyme differentiation, chondrocyte proliferation, and delaying mineralization by impairing vascular invasion.

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Section: Discussionsupporting

confidence: 72%

Exposure to excess phenobarbital negatively influences the osteogenesis of chick embryos

Yu¹

2017

J Pharm Drug Deliv Res

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“…Other investigations have also reported that smooth surfaces favor human oral fibroblast attachment, 26,27 whereas rough surfaces favor osteoblast adhesion and growth. [28][29][30] Our study demonstrated that compared with rough surface (Ra 5 0.19 lm), smooth surface (Ra 5 0.05 lm) only favored HGFs 48 h proliferation and collagen release after 3 and 7 days. With regard to adhesive density and morphology, surfaces with diverse roughness had no significant difference.…”

Section: Discussionmentioning

confidence: 91%

Ultraviolet light-treated zirconia with different roughness affects function of human gingival fibroblastsin vitro: The potential surface modification developed from implant to abutment

Yang

Zhou

Liu

et al. 2014

J. Biomed. Mater. Res.

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“…The roughness-bacterial adhesion correlation has been widely investigated for Ti-based surfaces and it has been proposed that bacterial adhesion decreases as the surface roughness (average roughness, R a ) is reduced up to a threshold limit [15,[63][64][65]. Below this limit (Ra b 0.2 μm) no further reduction is observed, however, such low roughness is not of interest for clinical applications since it inhibits proper implant anchoring [8,9]. Although in those studies different bacteria strains have been used, the effect of the real bacterial size has not been discussed.…”

Section: Discussionmentioning

confidence: 99%

“…Despite these good properties, some surface modifications have also been introduced to improve the bone-to-implant contact area trying to reduce the loading-time of the implant [6,7]. It has been shown that Ti surfaces with micro-scale roughened surfaces, in the range of 1-10 μm, maximize the interlocking between mineralized bone and the implant surface as well as enhance the proliferation and differentiation of osteoblastic cells [8,9]. Some studies have shown that roughness at the nanometer level also plays a relevant role [10,11].…”

Section: Introductionmentioning

confidence: 99%