The Effect of Neuroticism on the Recall of Persistent Low-Back Pain and Perceived Activity Interference

Lefebvre, John C.; Keefe, Francis J.

doi:10.1016/j.jpain.2013.03.006

Cited by 14 publications

(14 citation statements)

References 34 publications

(39 reference statements)

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“…39 Neuroticism has also been independently associated with greater pain catastrophizing and pain-related anxiety. 40 Our genetic correlation results were consistent with findings from epidemiological studies of headache, 41 neck or shoulder pain, 42 back pain, 43 and pain all over the body. 44 No previous studies have shown epidemiological data for the relationships between neuroticism and facial pain or stomach or abdominal pain.…”

Section: Discussionsupporting

confidence: 87%

“…20 It has been proposed that some pain phenotypes (such as migraine, back pain) and some psychiatric traits (such as depression or neuroticism) share common genetic components. 21-24 However, the genetic correlations between multiple pain phenotypes in different body sites, and those between pain phenotypes and depressive symptoms, major depressive disorders and neuroticism, have not been reported systematically, to the best of our knowledge.…”

Section: Introductionmentioning

confidence: 99%

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Genetic correlations between pain phenotypes and depression and neuroticism

Wang

Adams

Deary

et al. 2018

Preprint

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19Correlations between pain phenotypes and psychiatric traits such as depression and 20 the personality trait of neuroticism are not fully understood. The purpose of this study 21 was to identify whether eight pain phenotypes, depressive symptoms, major 22 depressive disorders, and neuroticism are correlated for genetic reasons. Eight pain 23 phenotypes were defined by a specific pain-related question in the UK Biobank 24 questionnaire. First we generated genome-wide association summary statistics on 25 each pain phenotype, and estimated the common SNP-based heritability of each trait 26 using GCTA. We then estimated the genetic correlation of each pain phenotype with 27 depressive symptoms, major depressive disorders and neuroticism using the the 28 cross-trait linkage disequilibrium score regression (LDSC) method integrated in the 29 LD Hub. Third, we used the LDSC software to calculate genetic correlations among 30 pain phenotypes. All pain phenotypes were heritable, with pain all over the body 31showing the highest heritability (h 2 =0.31, standard error=0.072). All pain phenotypes, 32 except hip pain and knee pain, had significant and positive genetic correlations with 33 depressive symptoms, major depressive disorders and neuroticism. The largest 34 genetic correlations occurred between neuroticism and stomach or abdominal pain 35 (rg=0.70, P=2.4 x 10 -9 ). In contrast, hip pain and knee pain showed weaker evidence 36 of shared genetic architecture with these negative emotional traits. In addition, many 37 pain phenotypes had positive and significant genetic correlations with each other 38 indicating shared genetic mechanisms. Pain at a variety of body sites is heritable 39 and genetically correlated with depression and neuroticism. This suggests that pain, 40 neuroticism and depression share partially overlapping genetic risk factors. 41 experience of pain could help our understanding of its aetiology and prevention, and 56 might also offer opportunities for personalised medicine and drug targeting based on 57 identified genetic variants. Although some genetic studies have focused on pain in 58 specific body sites and have suggested possible genetic variants associated with 59 pain phenotypes, 5 the overall understanding of the genetic contributions of pain 60 remain unclear. Current limitations in our knowledge include: 1. the extent to which 61 pain as a phenotype is determined by additive genetic components mainly 62represented by single nucleotide polymorphisms (SNPs); 2. whether the genetic 63 mechanisms of pain in different body sites or in different disorders are similar or 64 different; and 3. whether the genetic connections between pain phenotypes and 65 other common co-morbidities are similar or different. Addressing these questions 66 brings further challenges when the severity and the frequency of pain are taken into 67 account. 68 4 Mental health disorders are among the commonest co-morbidities of pain. 6-7 69Depression was ranked as the third most important cause of disability worldwide, 70 a...

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Genetic correlations between pain phenotypes and depression and neuroticism

Wang

Adams

Deary

et al. 2018

Preprint

View full text Add to dashboard Cite

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“…Depression was ranked as the third most important cause of disability worldwide and neuroticism was also with significant global These authors contributed equally: Weihua Meng, Mark J. Adams health impacts [1,8]. Many pain phenotypes have been shown to be associated with depression and neuroticism in epidemiological studies [9][10][11][12][13][14][15][16][17][18]. This epidemiological coexistence could arise in part because of shared genetic factors [19,20].…”

Section: Introductionmentioning

confidence: 99%

“…Understanding the genetic correlations between pain, depression and neuroticism may help to elucidate their degree of shared genetic architecture and provide a framework for future causal inference [21]. It has been proposed that some pain phenotypes (such as migraine, back pain) and depression or neuroticism share common genetic components [17,[22][23][24]. However, to the best of our knowledge, the genetic correlations between multiple pain phenotypes in different body sites, and those between pain phenotypes and depressive symptoms, major depressive disorders and neuroticism, have not been reported systematically.…”

Section: Introductionmentioning

confidence: 99%

Genetic correlations between pain phenotypes and depression and neuroticism

et al. 2019

View full text Add to dashboard Cite

Correlations between pain phenotypes and psychiatric traits such as depression and the personality trait of neuroticism are not fully understood. In this study, we estimated the genetic correlations of eight pain phenotypes (defined by the UK Biobank, n = 151,922-226,683) with depressive symptoms, major depressive disorders and neuroticism using the the crosstrait linkage disequilibrium score regression (LDSC) method integrated in the LD Hub. We also used the LDSC software to calculate the genetic correlations among pain phenotypes. All pain phenotypes, except hip pain and knee pain, had significant and positive genetic correlations with depressive symptoms, major depressive disorders and neuroticism. All pain phenotypes were heritable, with pain all over the body showing the highest heritability (h 2 = 0.31, standard error = 0.072). Many pain phenotypes had positive and significant genetic correlations with each other indicating shared genetic mechanisms. Our results suggest that pain, neuroticism and depression share partially overlapping genetic risk factors.

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“…The confirmed positive association of neuroticism with pain (Pearce & Porter, 1983) may be explained by the fact that this personality trait lowers the threshold at which pain is perceived as threatening (Goubert et al, 2004). Higher neuroticism is also known to result in better recall of pain unpleasantness (Lefebvre & Keefe, 2013). Conscientiousness has been explored in a few studies on labor pain .…”

Section: Discussionmentioning

confidence: 99%

Personality, cognitive appraisal and labor pain

Kwissa-Gajewska¹,

Dołęgowska²

2017

Health Psychology Report

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The theories focusing on the central neural mechanisms also pointed to the role of psychological factors in shaping painful sensations. The aim of the study was to explore direct and indirect effects of personality and cognitive appraisal of childbirth on experienced labor pain. participants and procedureLabor pain was assessed twice by forty-five childbearing women aged 18-45 (M = 28.31, SD = 5.20; 23 participants were primiparous): on admission to the obstetrics clinic and two days postpartum. On the first occasion, experienced and anticipated pain (VAS) and cognitive appraisal of labor (KOS) were measured, while the second assessment included rating of pain in the second stage of labor (VAS) and personality traits (NEO-FFI). resultsMediation analyses indicated indirect effects of conscientiousness on pain at the first stage of labor via challenge appraisal and of neuroticism and conscientiousness on recalled second stage labor pain intensity via threat/loss appraisal. Irrespective of personality traits, correlations were found between pain and cognitive appraisal in terms of threat/loss and challenge.

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The Effect of Neuroticism on the Recall of Persistent Low-Back Pain and Perceived Activity Interference

Cited by 14 publications

References 34 publications

Genetic correlations between pain phenotypes and depression and neuroticism

Genetic correlations between pain phenotypes and depression and neuroticism

Genetic correlations between pain phenotypes and depression and neuroticism

Personality, cognitive appraisal and labor pain

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