Renal GLUT1 reduction depends on angiotensin-converting enzyme inhibition in diabetic hypertensive rats

Abstract

We concluded that the blockade of the renin-angiotensin system with ramipril reduced early markers of diabetic nephropathy, a phenomenon that cannot be specifically related to decreased BP levels.

The role of kinin B1receptor and the effect of angiotensin I-converting enzyme inhibition on acute gout attacks in rodents

“…For the kininase II activity, ankle tissue samples (synovium and capsule) were incubated in the presence of a kininase II substrate, (N-(3-(2-furyh)-acryloyl)-L-phenylalanylglycylglycine (FAPGG) 32. The product was measured colorimetrically (340 nm), and the results were expressed as µmol of cleaved substrate/minute.…”

Effect of Insulin on Proximal Tubules Handling of Glucose: A Systematic Review

“…They predominantly reported higher GLUT1 protein [79][80][81][82] and corresponding mRNA [81][82][83][84][85] contents in the whole kidney and increased GLUT1 protein [86,87] and mRNA [86,88,89] in the cortex. Nonetheless, these studies are yet controversial [22,67,[90][91][92][93]. In STZ rats, S3 GLUT1 mRNA availability raised and returned to its normal values after one month of diabetes induction, while cortical (mainly S1 and S2 segments) GLUT1 remained at low levels until six months.…”

Sodium-glucose transporter 2 inhibitors in type 2 diabetes mellitus: navigating between Scylla and Charybdis

“…Diabetes-induced increase of SGLT2 and GLUT2 expression in proximal tubule participates in the development of diabetic tubulopathy and glomerulopathy. We have investigated mechanisms involved in diabetes-induced renal regulation of SGLT2, SGLT1, GLUT2 and GLUT1, demonstrating hyperglycemia [3] and local angiotensin concentration [4] as powerful regulators.…”