Brachytherapy-based partial breast irradiation is associated with low rates of complications and excellent cosmesis

Shah, Chirag; Khwaja, Shariq S.; Badiyan, Shahed N.; Wilkinson, J. Ben; Vicini, Frank A.; Beitsch, Peter D.; Keisch, Martin; Arthur, Douglas W.; Lyden, Maureen

doi:10.1016/j.brachy.2013.04.005

Cited by 41 publications

(35 citation statements)

References 20 publications

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“…A balloon-based catheter delivers RT to the lumpectomy site using an intraluminal device (see Figures 2 and 3) by skilled surgical and radiation oncologists (Barry et al, 2013;Shah, Khwaja, et al, 2013;Skowronek et al, 2012). This procedure was developed to obviate the multiple catheters and technical skill of interstitial APBI.…”

Section: Types and Side Effectsmentioning

confidence: 99%

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Accelerated Partial Breast Irradiation

Bauer

Lester

2014

Clinical Journal of Oncology Nursing

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Local therapies to treat newly diagnosed breast cancer include a lumpectomy with radiation therapy or a mastectomy. The 20-year data from studies about the safety and efficacy of lumpectomy with full-breast radiation therapy support the safety of this regimen and its role to decrease the risk of ipsilateral recurrence and increase long-term survivorship of women with breast cancer. Accelerated partial breast irradiation (APBI) provides radiation therapy to the tumor bed but spares the remaining breast tissue. APBI accelerates the time required to complete the therapy regimen, with a range of one intraoperative session to five consecutive days compared to five to seven weeks. Several techniques exist to administer APBI, including the insertion of a balloon into the lumpectomy space. Of interest is the widespread use of APBI in community and academic settings that has preceded outcomes of large, randomized clinical trials. Because of selection bias in a number of small, single-institution, nonrandomized studies, published data are of limited value to ensure APBI as a standard of care.

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Section: Types and Side Effectsmentioning

confidence: 99%

“…The water-filled vessel is inflated to adapt to the resection site; the radioactive source is delivered via channels for twice daily treatments for five days for a total of 10 treatments. The device is removed after the last treatment (Shah, Khwaja, et al, 2013).…”

Section: Types and Side Effectsmentioning

confidence: 99%

Accelerated Partial Breast Irradiation

Bauer

Lester

2014

Clinical Journal of Oncology Nursing

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“…Elle a été essentiellement utilisée aux États-Unis à partir de 2002, date d'approbation de ce dispositif par la Food and Drug Administration. Les études prospectives ont un suivi plus limité, allant de 13 à 65 mois [29][30][31][32][33]. Les doses correspondent à celles administrées en curiethérapie interstitielle de haut débit de dose.…”

Section: Curiethérapie Par Ballonnetunclassified

“…Le taux d'infection a été de 9,3 %, le taux de séromes de 32,6 % et celui de cytostéatoné-croses asymptomatiques de 9,3 %. Les autres études prospectives ont retrouvé des résultats globalement aussi bons [32].…”

Section: Curiethérapie Par Ballonnetunclassified

État de l’art et perspectives de l’irradiation partielle et accélérée du sein en 2014

Chand-Fouché

Hannoun‐Lévi

2014

Cancer/Radiothérapie

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“…With respect to toxicity, data from a randomized Hungarian trial has demonstrated no difference in local control (5.1% WBI vs. 5.9% APBI) and improved cosmetic outcomes with partial breast (63% excellent/good WBI vs. 81% APBI) as compared to standard WBI, while the Group Europeen de Curietherapie and the European Society for Radiotherapy and Oncology randomized trial evaluated interstitial brachytherapy and found no difference in the rates of local recurrence (0.9% WBI vs. 1.4% APBI) and a trend for reduced late grade 2 to 3 skin toxicity (5.7% WBI vs. 3.2% APBI) with APBI as compared to WBI [5,6]. Similarly, review of the literature has demonstrated excellent cosmetic outcomes with applicator brachytherapy as compared to traditional techniques [7]. External-beam APBI was originally performed using threedimensional conformal radiotherapy (3D-CRT) (34 Gy/10 fractions, twice daily) with concerns raised regarding toxicity and cosmetic outcomes [8,9]; however, advances in the technique have shown promise for improved outcomes.…”

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confidence: 97%