Cord blood haemoglobin and ferritin concentrations in newborns of anaemic and non-anaemic mothers in Lagos, Nigeria

Adediran, Adewumi; Gbadegesin, Abidoye; Adeyemo, Titilope A.; Akinbami, Akinsegun; Osunkalu, Vincent Oluseye; Ogbenna, Ann Abiola

doi:10.4103/0300-1652.108889

Cited by 19 publications

(24 citation statements)

References 14 publications

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“…Mean gestational age was 38.35 ± 0.8SD. It was comparable to the study done by Paulo et al, Betelihem et al, 16 Adewuni et al, 17 Hadipour et al 15 and Jie Shao et al 18 where all the participating women were in their their third trimester with period of gestation >-37 weeks.…”

Section: Discussionsupporting

confidence: 86%

Association of maternal serum ferritin concentration with newborn iron stores in anemic women in late pregnancy

Mônica¹,

Maheshwari²,

Bamaniya³

2020

IJOGR

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Pregnant women are particularly vulnerable to Iron deficiency because of the increased metabolic demands imposed by pregnancy involving a growing placenta, fetus and maternal tissues, coupled with associated dietary risks. Maternal iron deficiency has effects on fetal iron stores. The fetus receives iron indirectly from the maternal circulation through a rapid and unidirectional process. Thus, this study was planned to determine association between maternal serum ferritin and new born serum ferritin levels. In this observational cross sectional study randomized sample of 100 antenatal women, >20years of age with Hb <11gm/dl and period of gestation >37 weeks was taken for study. Serum ferritin was estimated by ELISA technique. Hb levels ranged from 3.8-10.7grams/dl with a mean value of 9.77±1.55gram/dl. Parity is of significance for severity of Anaemia (p=0.002). Mean gestational age was 38.35±0.85. No correlation was found between the maternal haemoglobin and maternal serum ferritin levels in women with mild and moderate Anaemia. But in cases of severe Anaemia a positive correlation was found with a p<0.001. The mean cord blood serum ferritin was 57.36±19.48 micrograms. This study establishes the effect of iron deficiency anaemia on neonatal iron status with increasing severity of anaemia and emphasizes on the need for iron supplementation during pregnancy.

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Section: Discussionsupporting

confidence: 86%

Association of maternal serum ferritin concentration with newborn iron stores in anemic women in late pregnancy

Mônica¹,

Maheshwari²,

Bamaniya³

2020

IJOGR

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“…The overall anemia prevalence among newborn babies was 25% (95% CI: 18.9, 31.1%). According to WHO recommendation our finding showed a moderate public health problem in the study area [15]. Due to reduced oxygen-carrying capacity; anemia has a still serious public health implication that leads to newborn morbidity and mortality [16].…”

Section: Discussionmentioning

confidence: 99%

Prevalence and associated factors of anemia among full-term newborn babies at University of Gondar comprehensive specialized hospital, Northwest Ethiopia: a cross-sectional study

2020

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Background: Anemia in newborn babies causes asymptomatic to an acute life-threatening event. If untreated, it leads to a delay in brain maturation, tissue hypoxia, and stunted growth. In Sub-Saharan Africa, its burden ranges 23-66%. However, in Ethiopia, there is limited information regarding the prevalence and associated factors of newborn anemia. Thus, this study was aimed to assess the prevalence and associated factors of anemia among fullterm newborn babies. Method: Cross-sectional study was conducted from February 1 to April 30, 2019, among 192 full-term newborn babies. A systematic random sampling technique was employed to select study participants. Socio-demographic characteristics were collected through interviews. Clinical data were collected by reviewing medical records. Cord blood was collected from the clumped cord. Complete blood count was analyzed by using the Sysmex KX-21 N hematology analyzer. SPSS 20 was used to analyze the data. Bivariable and multivariable binary logistic regression were used to identify associated factors. P-value < 0.05 was considered a statistically significant association. Result: The median (interquartile range) of cord hemoglobin was 15 g/dL (13.93-16.2 g/dL). From the total, 25% (95% CI: 18.9, 31.1%) of the newborns were anemic. From anemic 89.5, 6.3, and 4.2% were mild, moderate and severe anemia type, respectively. Maternal vegetable consumption habit (AOR = 0.34, 95%CI: 0.17, 0.69) were significant associated with anemia. Conclusion: Anemia among newborn babies found to be a moderate public health problem. Based on the finding early screening of newborn anemia may reduce further complications.

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“… 14 Our results, therefore, agree with previous studies on the ferritin level of pregnant and non-pregnant subjects, which concluded that iron deficiency did not have a high prevalence in Nigeria. 15 , 16 Of importance, in this study, however, is the observation of different degrees of iron deficiency and sideropenia in which some women who had no anemia were found with iron deficiency. This may stem from the fact that iron deficiency occurs in stages, and the women observed with sideropenia may be in the early stage where serum ferritin is significantly reduced with no obvious change in the hemoglobin level.…”

Section: Discussionmentioning

confidence: 82%

Rate and predictors of low serum ferritin levels among healthy parturient women in Enugu, Nigeria

Emegoakor

Iyoke

Ezegwui

et al. 2015

JBM

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BackgroundLow serum ferritin levels signify low iron stores and this could predispose to iron deficiency anemia.ObjectiveTo determine the rate and predictors of low serum ferritin levels during the puerperium in Enugu, Southeast Nigeria.Study designA hospital-based prospective longitudinal study involving parturient women who delivered singleton fetuses at term. Venous blood samples were collected to determine the serum ferritin concentration at 48 hours and 6 weeks postpartum. Data analysis involved descriptive and inferential statistics at 95% confidence interval (CI) using Statistical Package for Social Sciences (SPSS) computer software version 20.0.ResultsTwo-hundred and two women who carried singleton pregnancies to term were studied. The mean serum ferritin levels at 48 hours and 6 weeks were 27.82±18.41 µg/L and 36.12±21.53 µg/L, respectively. Forty-eight hours postdelivery, 29.2% had low ferritin levels and this decreased to 12.4% at 6 weeks postpartum. There was a significant positive correlation between the serum ferritin level at 48 hours postdelivery and the serum ferritin level at 6 weeks postpartum (r=0.89, P<0.001). Predictors of the low ferritin level at 6 weeks included age <20 years (odds ratio [OR] =0.70, 95% CI =0.53, 0.93), multiparity (OR =63.7, 95% CI =3.18, 127.5), anemia at 48 hours postpartum (OR =61.7, 95% CI =13.27, 116.6), a low ferritin level at 48 hours (OR =78.1, 95% CI =8.8, 108.3), and intake of antenatal hematinics for <3 months (OR =0.04, 95% CI =0.01, 0.20).ConclusionThere was a significant occurrence of low ferritin levels during the puerperium in the study centers, and this was associated mainly with pregnancy and delivery factors. Efforts to improve the iron stores in parturient women could benefit from early booking and compliance with antenatal hematinics and optimizing hemoglobin and iron levels before delivery.

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Cord blood haemoglobin and ferritin concentrations in newborns of anaemic and non-anaemic mothers in Lagos, Nigeria

Cited by 19 publications

References 14 publications

Association of maternal serum ferritin concentration with newborn iron stores in anemic women in late pregnancy

Association of maternal serum ferritin concentration with newborn iron stores in anemic women in late pregnancy

Prevalence and associated factors of anemia among full-term newborn babies at University of Gondar comprehensive specialized hospital, Northwest Ethiopia: a cross-sectional study

Rate and predictors of low serum ferritin levels among healthy parturient women in Enugu, Nigeria

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