Influence of Coffee Brew in Metabolic Syndrome and Type 2 Diabetes

Abrahão, Sheila Andrade; Pereira, Rosemary Gualberto Fonseca Alvarenga; Sousa, Raimundo Vicente de; Lima, Adriene Ribeiro; Crema, G; Barros, Bianca Sacramento

doi:10.1007/s11130-013-0355-z

Cited by 21 publications

(19 citation statements)

References 15 publications

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“…These data provide evidence of the beneficial modification of microbiota composition by the diets supplemented with phenolic acids from coffee, which was also observed by Rao et al [23]. The inclusion of CGAs inside the molecules of β-cyclodextrin increased their bioavailability because of the limited interactions with the other components of the diet and bread [13, 17, 25]. …”

Section: Resultssupporting

confidence: 77%

“…CGAs exhibit a broad range of biological activities: anti-thrombotic, anti-inflammatory, hypoglycemic and antioxidant [7–10]. CGAs decrease the risk of several oxidative stress-related diseases, including atherosclerosis, some kinds of cancer and type 2 diabetes [11–13]. Because the concentration of CGAs is significantly reduced by roasting, these compounds should be extracted from green coffee.…”

Section: Introductionmentioning

confidence: 99%

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Influence of the Form of Administration of Chlorogenic Acids on Oxidative Stress Induced by High fat Diet in Rats

Budryn

Zaczyńska

Żyżelewicz

et al. 2017

Plant Foods Hum Nutr

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Green coffee is one of health-promoting supplements of the diet, applied in the form of either preparations or enriched food products. Its positive impact is manifested by mitigation of the development of certain tumors, e.g., in the colon and liver, and type 2 diabetes. Many studies proved that chlorogenic acids are the main active substances in green coffee. The bioavailability of these compounds depends among others on their interactions with other components of the diet, mainly proteins. When they are used as food ingredients, their bioavailability is additionally decreased because of the decomposition or interactions with other ingredients during food processing. The undesirable changes may be limited among others by microencapsulation, for example with β-cyclodextrin. In this study, rats were fed the pro-oxidative high fat diet, which was supplemented with chlorogenic acids from green coffee that were used in four forms such as: a purified extract, complexes of chlorogenic acids and β-cyclodextrin, and bread supplemented with either the extract or the β-cyclodextrin inclusion complex. Chlorogenic acids added to bread because of the reduced absorption from the crumb in the small intestine and increased passage to the colon, contributed to the beneficial modification of enzymatic activities of intestinal microbiota. When added directly to the diet, they contributed to the improved antioxidant status in the liver and kidneys, lowered glucose level and increased HDL level. A high ratio of reduced to oxidized glutathione in the liver and a high concentration of antioxidants in the blood serum were observed after administration of chlorogenic acids in the form of inclusion complexes with β-cyclodextrin, indicating that microencapsulation increased their bioaccessibility due to the limited interactions with other components of the diet.

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Section: Resultssupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Influence of the Form of Administration of Chlorogenic Acids on Oxidative Stress Induced by High fat Diet in Rats

Budryn

Zaczyńska

Żyżelewicz

et al. 2017

Plant Foods Hum Nutr

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“…The results demonstrated that coffee supplementation attenuated the onset of common MetS features as well as and the development of NAFLD in experimental animals, without significant effects of abdominal obesity . Similarly, a study conducted in diabetic Zucker rats affected by the MetS showed that daily doses of coffee drink given by gavage for 30 days resulted in significant hypoglycaemic and hypolipidaemic effects, ultimately protecting against the development of an adverse metabolic profile …”

Section: Resultsmentioning

confidence: 84%

“…Three experimental animal studies investigated the effects of coffee in the MetS, whereas five examined whether experimental coffee intake may modulate the risk of fatty liver infiltration …”

Section: Resultsmentioning

confidence: 99%

Review article: coffee consumption, the metabolic syndrome and non-alcoholic fatty liver disease

Yeşıl

Yılmaz

2013

Aliment Pharmacol Ther

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Summary Background Coffee consumption may modulate the risk of the metabolic syndrome (MetS) and non‐alcoholic fatty liver disease (NAFLD). Aim To review the experimental, epidemiological and clinical studies investigating the association between coffee consumption and the risk of MetS and NAFLD. Methods A literature search was conducted with the aim of finding original experimental, epidemiological and clinical articles on the association between coffee consumption, MetS and NAFLD. The following databases were used: PubMed, Embase, Scopus and Science Direct. We included articles written in English and published up to July 2013. Results Three experimental animal studies investigated the effects of coffee in the MetS, whereas five examined whether experimental coffee intake may modulate the risk of fatty liver infiltration. All of the animal studies showed a protective effect of coffee towards the development of MetS and NAFLD. Moreover, we identified eleven epidemiological and clinical studies that met the inclusion criteria. Of them, six were carried out on the risk of the MetS and five on the risk of NAFLD. Four of the six studies reported an inverse association between coffee consumption and the risk of MetS. The two studies showing negative results were from the same study cohort consisting of young persons with a low prevalence of the MetS. All of the epidemiological and clinical studies on NAFLD reported a protective effect of coffee intake. Conclusions Coffee intake can reduce the risk of NAFLD. Whether this effect may be mediated by certain components of the MetS deserves further investigation.

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“…Because of its impact on the pro-inflammatory state, the role of coffee consumption has been explored both in NAFLD and MS (Table 2) [60]. Coffee supplementation attenuates the expected onset of an adverse metabolic pattern in animals fed high-fat diets [52,53].…”

Section: Nalfd: the Liver At The Centermentioning

confidence: 99%

Nonalcoholic fatty liver disease as trigger of cardiovascular and metabolic complication in metabolic syndrome

et al. 2015

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Influence of Coffee Brew in Metabolic Syndrome and Type 2 Diabetes

Cited by 21 publications

References 15 publications

Influence of the Form of Administration of Chlorogenic Acids on Oxidative Stress Induced by High fat Diet in Rats

Influence of the Form of Administration of Chlorogenic Acids on Oxidative Stress Induced by High fat Diet in Rats

Review article: coffee consumption, the metabolic syndrome and non-alcoholic fatty liver disease

Nonalcoholic fatty liver disease as trigger of cardiovascular and metabolic complication in metabolic syndrome

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