Association between major depressive disorder and the norepinephrine transporter polymorphisms T-182C and G1287A: A meta-analysis

Zhao, Xiaofeng; Huang, Yinglin; Ma, Hui; Qiu, Jin; Wang, Yuan; Zhu, Gang

doi:10.1016/j.jad.2013.03.016

Cited by 30 publications

(10 citation statements)

References 38 publications

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“…Research suggested that it is essential to inhibit norepinephrine transporter for the synergism of analgesic effect from monoamine transmitter reuptake inhibitors and of opioid drugs [ 13 ]. Cerebral NET activity was associated with agitation of PTSD (posttraumatic stress disorder) patients [ 14 ]. As a membrane-bound G protein-coupled receptor, α 2AR can amplify and transduce the extracellular stimulating signal into cells to trigger intracellular biological reactions.…”

Section: Discussionmentioning

confidence: 99%

Effects of Electroacupuncture on Pain Threshold of Laboring Rats and the Expression of Norepinephrine Transporter and α2 Adrenergic Receptor in the Central Nervous System

Tang

Jiang

Sooranna

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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To observe the effects of electroacupuncture on pain threshold of laboring rats and the expression of norepinephrine transporter and α2 adrenergic receptor in the central nervous system to determine the mechanism of the analgesic effect of labor. 120 pregnant rats were divided into 6 groups: a control group, 4 electroacupuncture groups, and a meperidine group. After interventions, the warm water tail-flick test was used to observe pain threshold. NE levels in serum, NET, and α2AR mRNA and protein expression levels in the central nervous system were measured. No difference in pain threshold was observed between the 6 groups before intervention. After intervention, increased pain thresholds were observed in all groups except the control group with a higher threshold seen in the electroacupuncture groups. Serum NE levels decreased in the electroacupuncture and MP groups. Increases in NET and α2AR expression in the cerebral cortex and decreases in enlarged segments of the spinal cord were seen. Acupuncture increases uptake of NE via cerebral NET and decreases its uptake by spinal NET. The levels of α2AR are also increased and decreased, respectively, in both tissues. This results in a decrease in systemic NE levels and may be the mechanism for its analgesic effects.

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Section: Discussionmentioning

confidence: 99%

Effects of Electroacupuncture on Pain Threshold of Laboring Rats and the Expression of Norepinephrine Transporter and α2 Adrenergic Receptor in the Central Nervous System

Tang

Jiang

Sooranna

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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“…The data analysis and statistical methods were carried out according to the methods described in our previous studies (Zhao et al ., , ). All statistical calculations were performed using STATA 12.0 software (Stata Corp., College Station, TX, USA).…”

Section: Methodsmentioning

confidence: 99%

−141C insertion/deletion polymorphism of the dopamine D2 receptor gene is associated with schizophrenia in Chinese Han population: Evidence from an ethnic group‐specific meta‐analysis

Zhao

Huang

Chen

et al. 2015

Asia-Pacific Psychiatry

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Accumulate evidence has implicated dopamine D2 receptor gene polymorphisms in the etiology of schizophrenia. A single nucleotide polymorphism, -141C insertion/deletion (Ins/Del) (rs1799732), in the promoter region of the dopamine D2 receptor gene has been linked to schizophrenia; however, the data are inconclusive. This study investigated whether the -141C polymorphism is associated with the risk of schizophrenia in different ethnic groups by performing a meta-analysis. A total of 24 case-control studies examining the association between -141C Ins/Del polymorphism and schizophrenia were identified according to established inclusion criteria. Significant association was revealed between -141C Ins/Del polymorphism and schizophrenia risk in dominant genetic model (Ins/Ins + Ins/Del versus Del/Del) (odds ratio = 0.33, 95% confidence interval = 0.14-0.81, z = 2.41, P = 0.02) in Chinese Han but not in Caucasian, Japanese or India populations. Our results indicate that -141C Ins/Del polymorphism might be a susceptibility factor for schizophrenia in Chinese Han population.

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“…A possible association of one variant in the alpha 2A-adrenergic receptor (ADRA2A C-1297G) with milnacipran response was suggested in one study; however, larger sample sizes are required to further validate these results [106]. Another study suggested an association of the genetic variant T-182C in the NET gene (SLC6A2) with better therapy response and an association of the SLC6A2 variant G1287A with a slower therapeutic response onset in depression [107,108]. No distinct treatment guidelines in dependence of genetic polymorphisms are given by the CPIC or DPWG.…”

Section: Serotonin-norepinephrine Reuptake Inhibitorsmentioning

confidence: 99%

Therapy Response Prediction in Major Depressive Disorder: Current and Novel Genomic Markers Influencing Pharmacokinetics and Pharmacodynamics

et al. 2021

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Major depressive disorder is connected with high rates of functional disability and mortality. About a third of the patients are at risk of therapy failure. Several pharmacogenetic markers especially located in CYP450 genes such as CYP2D6 or CYP2C19 are of relevance for therapy outcome prediction in major depressive disorder but a further optimization of predictive tools is warranted. The article summarizes the current knowledge on pharmacogenetic variants, therapy effects and side effects of important antidepressive therapeutics, and sheds light on new methodological approaches for therapy response estimation based on genetic markers with relevance for pharmacokinetics, pharmacodynamics and disease pathology identified in genome-wide association study analyses, highlighting polygenic risk score analysis as a tool for further optimization of individualized therapy outcome prediction.

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Association between major depressive disorder and the norepinephrine transporter polymorphisms T-182C and G1287A: A meta-analysis

Cited by 30 publications

References 38 publications

Effects of Electroacupuncture on Pain Threshold of Laboring Rats and the Expression of Norepinephrine Transporter and α2 Adrenergic Receptor in the Central Nervous System

Effects of Electroacupuncture on Pain Threshold of Laboring Rats and the Expression of Norepinephrine Transporter and α2 Adrenergic Receptor in the Central Nervous System

−141C insertion/deletion polymorphism of the dopamine D2 receptor gene is associated with schizophrenia in Chinese Han population: Evidence from an ethnic group‐specific meta‐analysis

Therapy Response Prediction in Major Depressive Disorder: Current and Novel Genomic Markers Influencing Pharmacokinetics and Pharmacodynamics

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